Circular RNAs pp 287-297 | Cite as

Circular RNAs in Vascular Functions and Diseases

  • Shengguang Ding
  • Yujiao Zhu
  • Yajun Liang
  • Haitao Huang
  • Yiming Xu
  • Chongjun Zhong
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1087)


Vascular disease is one of the top five causes of death and affects a variety of other diseases, such as heart, nervous system, and metabolic disorders. Vascular dysfunction is a hallmark of ischemia, cancer, and inflammatory diseases and can accelerate the progression of diseases. Circular RNAs (circRNAs) are a new type of noncoding RNAs with covalent bond ring structure, which have been reported to be abnormally expressed in many human diseases. circRNAs regulate gene expression through the sponging of microRNAs (miRNAs) and can also be used as disease biomarkers. Here we will summarize the functions of circRNAs in vascular diseases, including vascular dysfunction, atherosclerosis, diabetes mellitus-related retinal vascular dysfunction, chronic thromboembolic pulmonary hypertension, carotid atherosclerotic disease, hepatic vascular invasion in hepatocellular carcinoma, aortic aneurysm, coronary artery disease, and type 2 diabetes mellitus.


Circular RNAs Vascular function Vascular diseases 


Competing Financial Interests

The authors declare no competing financial interests.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Shengguang Ding
    • 1
  • Yujiao Zhu
    • 2
    • 3
  • Yajun Liang
    • 2
    • 3
  • Haitao Huang
    • 1
  • Yiming Xu
    • 1
  • Chongjun Zhong
    • 1
  1. 1.Department of Thoracic and Cardiovascular SurgeryThe Second Affiliated Hospital of Nantong UniversityNantongChina
  2. 2.Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life ScienceShanghai UniversityShanghaiChina
  3. 3.Shanghai Key Laboratory of Bio-Energy Crops, School of Life SciencesShanghai UniversityShanghaiChina

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