The Chemistry of Human Exposure to Aluminium

  • Christopher ExleyEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1091)


Before it is possible to begin to understand the chemistry of human exposure to aluminium, it is necessary to appreciate a few basic rules. Rule number one tells us that the form of aluminium which is bound by functional groups on biomolecules is its free trivalent aqueous cation, Al3+(aq). Rule number two tells us that the binding of Al3+(aq) is determined by both thermodynamic and kinetic constraints. Rule number three tells us how essential it is to understand the critical importance of the exposure regime. The application of these simple rules of aluminium chemistry allows us to understand why, for example, not all aluminium salts are equal and not all routes of aluminium exposure are equivalent.


Human exposure to aluminium Thermodynamic and kinetic constraints Exposure regime Aluminium binding by biomolecules Aluminium adjuvants 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.The Birchall Centre, Lennard-Jones LaboratoriesKeele UniversityKeeleUK

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