Coagulopathy in Liver Disease
Liver plays an important role in coagulation. Apart from von Willebrand factor, all the other clotting factors are synthesized by the liver. Coagulopathy in liver disease is a reflection of synthetic liver failure. The normal coagulation cascade is outlined in Fig. 5.1. Always look for superimposed causes of coagulopathy such as vitamin K deficiency, infections, and renal failure.