Epidemiology of Crohn’s Disease in Japan

  • Koji Uchiyama
  • Mitsumasa Umesawa
  • Yasuo Haruyama
  • Toshimi Sairenchi
  • Gen KobashiEmail author
Part of the Current Topics in Environmental Health and Preventive Medicine book series (CTEHPM)


Crohn’s disease (CD) is a chronic inflammatory condition of the gastrointestinal tract that most commonly affects the small intestine and colon. Recent data indicate a growing incidence and prevalence of CD worldwide, and CD has become more common in Japan. This report aimed to review the epidemiology of CD in Japan. Japanese genome-wide association studies on CD revealed important race-specific results, such as lack of association with the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) locus. Moreover, CD has been considered a multifactorial disease of both genetic and environmental etiology. Therefore, studies on environmental factors and gene–environment interaction analyses are warranted in Japan.


Crohn’s disease Epidemiological studies Genetic factors Environmental factors Westernization Elemental diets Pregnancy outcome Japanese 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Koji Uchiyama
    • 1
  • Mitsumasa Umesawa
    • 2
  • Yasuo Haruyama
    • 2
  • Toshimi Sairenchi
    • 2
  • Gen Kobashi
    • 2
    Email author
  1. 1.Laboratory of International Environmental HealthCenter for International Cooperation, Dokkyo Medical UniversityTochigiJapan
  2. 2.Department of Public HealthDokkyo Medical University School of MedicineTochigiJapan

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