Recent Advancements in Decellularized Matrix-Based Biomaterials for Musculoskeletal Tissue Regeneration

  • Hyunbum Kim
  • Yunhye Kim
  • Mona Fendereski
  • Nathaniel S. Hwang
  • Yongsung HwangEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1077)


The native extracellular matrix (ECM) within different origins of tissues provides a dynamic microenvironment for regulating various cellular functions. Thus, recent regenerative medicine and tissue engineering approaches for modulating various stem cell functions and their contributions to tissue repair include the utilization of tissue-specific decellularized matrix-based biomaterials. Because of their unique capabilities to mimic native extracellular microenvironments based on their three-dimensional structures, biochemical compositions, and biological cues, decellularized matrix-based biomaterials have been recognized as an ideal platform for engineering an artificial stem cell niche. Herein, we describe the most commonly used decellularization methods and their potential applications in musculoskeletal tissue engineering.


Decellularization Extracellular matrix (ECM) Biomaterials Scaffold Microenvironment Musculoskeletal tissue regeneration 



This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2016K1A4A3914725) and partially supported by the Soonchunhyang University Research Fund.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Hyunbum Kim
    • 1
    • 2
  • Yunhye Kim
    • 2
  • Mona Fendereski
    • 2
  • Nathaniel S. Hwang
    • 1
  • Yongsung Hwang
    • 2
    Email author
  1. 1.School of Chemical and Biological EngineeringInstitute of Chemical Processes, Seoul National UniversitySeoulSouth Korea
  2. 2.Soonchunhyang Institute of Medi-bio Science (SIMS)Soonchunhyang UniversityCheonan-siSouth Korea

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