Novel Super-Regulators of Quorum Sensing in Pseudomonas aeruginosa

  • Chuanmin Zhou
  • Min WuEmail author


Quorum sensing (QS) systems are a vital network in Pseudomonas aeruginosa for regulating cell to cell communication. Many of this bacterial virulence factors are controlled by or associated with QS. As QS system may directly regulate up to 10% genes of P. aeruginosa, this system is of fundamental importance in bacterial physiology and pathogenesis. However, it is still unclear how the QS genes regulate their targets and how QS circuits are modulated by other regulators. Here, we review how a series of recently identified critical regulators, named “super-regulators” in P. aeruginosa, participate in QS signaling to modulate the expression of its effectors.


Quorum sensing Pseudomonas aeruginosa Two-component systems; 



Biofilm maturation


ClpAP-degradation and pathogenicity Regulatorregulator


Quorum-sensing control repressor


QS-repressing ORF


RNA polymerase sigma-54 factor


RNA polymerase, sigma S


Virulence and QS modulator


Virulence and quorum-sensing regulator


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Biomedical SciencesUniversity of North DakotaGrand ForksUSA
  2. 2.Wuhan University School of Health SciencesWuhan UniversityWuhanPeople’s Republic of China

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