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Understanding the Connect of Quorum Sensing and CRISPR-Cas System: Potential Role in Biotechnological Applications

  • Anoop Singh
  • Mohita Gaur
  • Richa Misra
Chapter

Abstract

Quorum sensing is employed by bacteria to control gene expression, by communicating through signals, necessary to confer advantageous traits in a community. We now understand that to counter susceptibility to phages in communities, bacteria evolved specialized adaptive immune system called CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins) system that may use quorum sensing for its regulation. As a countermeasure, phages have also evolved diverse mechanisms to evade the defense strategies. The chapter discusses the dynamics of this co-evolutionary war, understanding of which will help pave way for many biotechnological applications. An important aspect includes refining tools such as quorum-sensing inhibition and phage therapy that are utilized to control many biofilm-forming bacterial infections.

Keywords

Quorum sensing CRISPR-CAS system Biotechnology 

Notes

Acknowledgments

We sincerely acknowledge the support and guidance provided by Prof. Yogendra Singh, Department of Zoology, University of Delhi, for this work and Dr. Anupam Kumar Mondal, CSIR-IGIB, India for insights into the field of CRISPR biology.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Anoop Singh
    • 1
  • Mohita Gaur
    • 1
  • Richa Misra
    • 1
    • 2
  1. 1.Department of ZoologyUniversity of DelhiDelhiIndia
  2. 2.Department of Zoology, Sri Venkateswara CollegeUniversity of DelhiDelhiIndia

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