CRISPR-Cas Systems Regulate Quorum Sensing Genes and Alter Virulence in Bacteria

  • Qinqin Pu
  • Min WuEmail author


Although understanding how CRISPR and its associated systems are controlled is at the infant stages, recent studies present exciting discoveries in this fast-moving field. A number of studies find that CRISPR-Cas systems regulate quorum sensing (QS) genes by targeting and degrading lasR mRNA, while QS systems can also modulate the CRISPR-Cas as revealed in more recent reports. The importance of the QS system for bacterial pathogenicity is well recognized and the indispensable features of CRISPR-Cas in adaptive immunity and biotechnology application are gaining great attention. Analyzing interaction between QS and CRISPR-Cas systems represents an interesting field as CRISPR-Cas systems are not only the adaptive immunity of bacteria, but also the regulators of their own genes. Undoubtedly, the continued understanding of molecular basis of CRISPR-Cas action and regulation may indicate novel strategies for treatment of bacterial infections.


CRISPR-Cas systems Quorum sensing Endogenous gene targeting 


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Biomedical SciencesUniversity of North DakotaGrand ForksUSA
  2. 2.State Key Laboratory of Biotherapy, West China HospitalSichuan UniversityChengduChina

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