The Significance of Single-Cell Biomedicine in Stem Cells

  • Weishan Zhuge
  • Furong Yan
  • Zhitu Zhu
  • Xiangdong WangEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1068)


Clinical application of stem cells (SCs) progresses significantly in the treatment of a large number of diseases, e.g. leukemia, respiratory diseases, kidney disease, cerebral palsy, autism, or autoimmune diseases. Of those, the population, biological phenotypes, and functions of individual SCs are mainly concerned, due to the lack of cell separation and purification processes. The single-cell technology, including microfluidic technology and single-cell genome amplification technology, is widely used to study SCs and gains some recognitions. The present review will address the importance of single-cell technologies in the recognition and heterogeneity of SCs and highlight the significance of current single-cell approaches in the understanding of SC phenotypes. We also discuss the values of single-cell studies to overcome the bottleneck in explore of biological mechanisms and reveal the therapeutic potentials of SCs in diseases, especially tumor-related diseases, as new diagnostic and therapeutic strategies


Single-cell technology Stem cell Tumor Heterogeneity Microfluidics 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Weishan Zhuge
    • 1
  • Furong Yan
    • 2
  • Zhitu Zhu
    • 3
  • Xiangdong Wang
    • 1
    Email author
  1. 1.Zhongshan Hospital Institute of Clinical ScienceFudan University Shanghai Medical SchoolShanghaiChina
  2. 2.Department of Respiratory Pulmonary and Critical Care MedicineThe Second Hospital of Fujian Medical UniversityQuanzhouChina
  3. 3.The First Hospital of Jinzhou Medical UniversityJinZhouChina

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