Fungal Biotechnology: Role and Aspects

  • Debjani Mukherjee
  • Simranjeet Singh
  • Mohit Kumar
  • Vijay Kumar
  • Shivika Datta
  • Daljeet Singh Dhanjal


Sustainability has become the prominent necessity in every human event in today’s time, which can initiate from the household and leads to this planet earth. The Earth Summit organized by the United Nations has played the significant role in creating awareness about sustainable development to retort against the natural calamities, due to over-exploitation of natural resources and exponential growth of the human population for centuries. For the quest of sustainability, fungi have emerged as a suitable candidate. Fungi play a pivotal role in fundamental and modern processes of biotechnology. Nowadays many processes such as baking, brewing and the synthesis of alcohols, antibiotics, enzymes, organic acid as well as the additional pharmaceutical product are carried out using fungal bioproducts. Due to recent advances in genomics and rDNA technology, yeast and fungi have attained the forefront position because of their present industrial purposes. In general, the term “mycotechnology” is used, which states about the various roles of fungi with the addition to its impact on biotechnology as well as economy.

Fungi play the significant role in sustaining the health and terrestrial ecosystem. During disastrous event which leads to disruption of the earth ecosystem, fungi prepare themselves to prevail in the future. The aid of fungal population in sustaining the environment is showing promising result. About 90% of plant grows in symbiosis with fungi such as vesicular-arbuscular mycorrhizal (VAM) fungi, mycorrhizae, out of which Glomus is the most exploited genera (Van der Heijden et al. 1998). Fungi persisting on this earth have widespread complex relationship among the range of microbes, which can be arthropods, bacteria and nematodes. The dwelling zone of these fungi is named as the “rhizosphere”.

A fungus belongs to the group of Eukaryotes, which consists of microbes like moulds and yeast along with more familiar mushrooms. All of them are categorized under the kingdom Fungi. The fungi are omnipresent in every environment and play critical role in complex biological processes. Thus, it can work as decomposers, which aid in nutrient cycles, exclusively as symbiont as well as saprotrophs, in disintegrating the organic constituents into inorganic constituents, which gets retraced in the anabolic pathways of metabolic activities taking place in organism as well as plants.


Fungal biotechnology Fungal enzymes Bioprocessing Fermentation Secondary metabolites 


  1. Bending GD, Friloux M, Walker A (2002) Degradation of contrasting pesticides by white rot fungi and its relationship with ligninolytic potential. FEMS Microbiol Lett 212(1):59–63CrossRefPubMedGoogle Scholar
  2. Bennett JW (1997) White paper: genomics for filamentous fungi. Fungal Genet Biol 21:3–7CrossRefPubMedGoogle Scholar
  3. Bennett JW, Heller F, Case CL (1997) Bio-tech-nol-o-gy,n.: the many definitions of biotechnology. Soc Indust Microbiol News 47:240–243Google Scholar
  4. Blanchard AP, Hood L (1996) Sequence to array: probing the genome’s secrets. Nat Biotech 14:1649CrossRefGoogle Scholar
  5. Bolan NS (1991) A critical review on the role of mycorrhizal fungi in the uptake of phosphorus by plants. Plant Soil 134(2):189–207CrossRefGoogle Scholar
  6. Botstein D, Cherfitz SA, Cherry JM (1997) Yeast as a model organisms. Science 277:1259–1260CrossRefPubMedPubMedCentralGoogle Scholar
  7. Chang ST, Hayes WA (1978) The biology and cultivation of edible mushrooms. Academic Press, New YorkGoogle Scholar
  8. Crueger W, Crueger A (1982) Biotechnology: a textbook of industrial microbiology. Sinauer, SunderlandGoogle Scholar
  9. Davies RW (1991) Expression of heterologous genes in filamentous fungi. In: Peberdy JR, Caten CE, Ogden JE, Bennett JW (eds) Applied molecular genetics of fungi. Cambridge University Press, Cambridge, pp 103–117Google Scholar
  10. Demain AL (1981) Industrial microbiology. Science 214:987–991CrossRefPubMedGoogle Scholar
  11. Dodd JC (2000) The role of arbuscular mycorrhizal fungi in agro-and natural ecosystems. Outlook on Agriculture 29(1):55–62CrossRefGoogle Scholar
  12. Dujon B (1996) The yeast genome project; what did we learn? Trends Genet 12:263–270CrossRefPubMedGoogle Scholar
  13. Esser K (1997) Fungal genetics: from fundamental research to biotechnology. Prog Bot 58:3–38Google Scholar
  14. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF et al (1995) Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269:496–512CrossRefPubMedGoogle Scholar
  15. Godfrey T, West S (eds) (1996) Industrial enzymology, 2nd edn. Stockton Press, New YorkGoogle Scholar
  16. Gray WD (1970) The use of fungi as food and in food processing. CRC Crit Rev Food Technol 1:1–225CrossRefGoogle Scholar
  17. Hammell KE (1997) Fungal degradation of lignin. In: Cadisch G, Giller KE (eds) Driven by nature, plant litter quality and decomposition. CAB International, Wallingford, pp 33–45Google Scholar
  18. Hesseltine CW (1983) Microbiology of oriental fermented foods. Annu Rev Microbiol 37:575–592CrossRefPubMedGoogle Scholar
  19. Johansson JF, Paul LR, Finlay RD (2004) Microbial interactions in the mycorrhizosphere and their significance for sustainable agriculture. FEMS Microbiol Ecol 48(1):1–13CrossRefGoogle Scholar
  20. Kao CM, Katz L, Khosla C (1994) Engineered biosynthesis of a complete macrolactone in a heterologous host. Science 265:509–512CrossRefPubMedGoogle Scholar
  21. Kaufman DD, Blake J (1970) Degradation of atrazine by soil fungi. Soil Biol Biochem 2(2):73–80CrossRefGoogle Scholar
  22. Kearney PC, Kaufman DD, Sheets TJ (1965) Metabolites of simazine by Aspergillus fumigatus. J Agric Fd Chem 13:369–373CrossRefGoogle Scholar
  23. Kinghorn JR, Lucena N (1994) Biotechnology of filamentous fungi. In: Iberghin L, Frontali L, Sensi P (eds) ECB6: proceedings of the 6th European congress on biotechnology. Elsevier, pp 277–286Google Scholar
  24. Kumar V, Singh S, Singh J, Upadhyay N (2015) Potential of plant growth promoting traits by bacteria isolated from heavy metal contaminated soils. Bull Environ Contam Toxicol 94(6):807–814CrossRefPubMedGoogle Scholar
  25. Lutman BF (1929) Microbiology. McGraw Hill, New YorkGoogle Scholar
  26. Mishra V, Gupta A, Kaur P, Singh S, Singh N, Gehlot P, Singh J (2016) Synergistic effects of Arbuscular mycorrhizal fungi and plant growth promoting rhizobacteria in bioremediation of iron contaminated soils. Int J Phytoremediation 18(7):697–703CrossRefPubMedGoogle Scholar
  27. Monghan RL, Tkacz JS (1990) Bioactive microbial products: focus upon mechanisms of action. Annu Rev Microbiol 44:271–301CrossRefGoogle Scholar
  28. Moses V, Cape RE (eds) (1991) Biotechnology: the science and the business. Harwood Academic Publishers, LondonGoogle Scholar
  29. Orth AB, Tien M (1995) Biotechnology of lignin degradation. In: Esser K, Lemke PA (eds) The Mycota. II. Genetics and biotechnology. Springer, New York/Berlin/Heidelberg, pp 287–302CrossRefGoogle Scholar
  30. Pukkila PJ (1993) Methods of genetic manipulation in Coprinus cinereus. In: Chang ST, Buswell JA, Miles PG (eds) Genetics and breeding of edible mushrooms. Gordon and Breach, Amsterdam, pp 249–264Google Scholar
  31. Raper CA, Horton JS (1993) A strategy for isolating mushroom-inducing genes in edible basidiomycetes. In: Chang ST, Buswell JA, Miles PG (eds) Genetics and breeding of edible mushrooms. Gordon and Breach, Amsterdam, pp 285–295Google Scholar
  32. Rasmussen-Wilson SJ, Palas JS, Wolf VJ, Taft CS, Selitrennikoff CP (1997) Expression of a plant protein by Neurospora crassa. Appl Environ Microbiol 63:3488–3493PubMedPubMedCentralGoogle Scholar
  33. Singh S, Singh N, Kumar V, Datta S, Wani AB, Singh D, Singh K, Singh J (2016) Toxicity, monitoring and biodegradation of the fungicide carbendazim. Environ Chem Lett 14(3):317–329CrossRefGoogle Scholar
  34. Singh S, Kumar V, Chauhan A, Datta S, Wani AB, Singh N, Singh J (2017a) Toxicity, degradation and analysis of the herbicide atrazine. Environ Chem Lett:1–27Google Scholar
  35. Singh S, Kumar V, Upadhyay N, Singh J, Singla S, Datta S (2017b) Efficient biodegradation of acephate by Pseudomonas pseudoalcaligenes PS-5 in the presence and absence of heavy metal ions [Cu (II) and Fe (III)], and humic acid 3. Biotech 7(4):262Google Scholar
  36. Skatrud PI (1991) Molecular biology of the beta-lactam producing fungi. In: Bennett JW, Lasure LS (eds) More gene manipulations in fungi. Academic Press, San Diego, pp 364–395CrossRefGoogle Scholar
  37. Skatrud PI (1992) Genetic engineering of beta-lactam antibiotic biosynthetic genes in filamentous fungi. Tibtech 10:17–20CrossRefGoogle Scholar
  38. Takamine J (1894) United States Patents 525,820 and 525,823Google Scholar
  39. Thurston CF (1994) The structure and function of fungal laccases. Microbiology 140:19–26CrossRefGoogle Scholar
  40. Umezawa SI (1982) Low-molecular weight enzyme inhibitors of molecular origin. Annu Rev Microbiol 36:75–99CrossRefPubMedGoogle Scholar
  41. Underkofler, L.A. 1954. Fungal amylolytic enzymes. In: Underkofler, L.A., Hickey, R.J. (Eds.), Industrial Fermentations. Chemical Publishing Company, New York, pp. 94–118Google Scholar
  42. Van der Heijden MGA, Klironomos JN, Ursic M, Moutoglis P, Streitwolf-Engel R, Boller T, Wiemken A, Sanders IR (1998) Mycorrhizal fungal diversity determines plant biodiversity, eco- system variability and productivity. Nature 396:69–72CrossRefGoogle Scholar
  43. Von Wartburg A, Trabor R (1986) Chemistry of the natural cyclosporin metabolites. Prog Alleg 38:28–45Google Scholar
  44. Wainwright M (1990) Miracle cure-the story of antibiotics. Blackwell, OxfordGoogle Scholar
  45. Wosten H, Moukha S, Sietsma J, Wessels J (1991) Localization of growth and secretion of proteins in Aspergillus Niger. J Gen Microbiol 137:2017–2023CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Debjani Mukherjee
    • 1
  • Simranjeet Singh
    • 2
  • Mohit Kumar
    • 3
  • Vijay Kumar
    • 4
  • Shivika Datta
    • 5
  • Daljeet Singh Dhanjal
    • 2
  1. 1.Department of Civil and Environmental EngineeringUniversity of WindsorWindsorCanada
  2. 2.Department of BiotechnologyLovely Professional UniversityPhagwaraIndia
  3. 3.IDS Infotech LtdMohaliIndia
  4. 4.Department of ChemistryLovely Professional UniversityPhagwaraIndia
  5. 5.Department of ZoologyLovely Professional UniversityPhagwaraIndia

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