Neuropharmacology of Scutellaria baicalensis Georgi

  • Amritpal Singh Saroya
  • Jaswinder Singh


S. baicalensis Georgi having a common name Baikal skullcap is a member of family Lamiaceae. S. macrantha Fisch. is the synonym for S. baicalensis. S. baicalensis is cultivated in China, Korea, Mongolia, Siberia and the Russian Far East. S. baicalensis is one of the 50 fundamental herbs of the Chinese Materia Medica and is known as Huang Qin. The root is used in the medicine.


  1. Akabas MH. GABA receptor structure-function studies: a reexamination in light of new acetylcholine receptor structures. Int Rev Neurobiol. 2004;62:1–43.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Awad R, Arnason JT, Trudeau V, Bergeron C, Budzinski JW, Foster BC, Merali Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10:640–9.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acid receptors: classification on the basis of subunit structure and receptor function. Pharmacol Rev. 1988;50:291–313.Google Scholar
  4. Brock C, Whitehouse J, Tewfik I, Towell T. American Skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res. 2014;28:692–8.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Cheng Y, He G, Mu X, et al. Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile. Neurosci Lett. 2008;441:16–20.CrossRefPubMedPubMedCentralGoogle Scholar
  6. Derry JM, Dunn SM, Davies M. Identification of a residue in the gamma-aminobutyric acid type a receptor alpha subunit that differentially affects diazepam-sensitive and insensitive benzodiazepine site binding. J Neurochem. 2004;88:1431–8.CrossRefPubMedGoogle Scholar
  7. Huang WH, Chien PY, Yang CH, Lee AR. Novel synthesis of flavonoids of Scutellaria baicalensis Georgi. Chem Pharm Bull (Tokyo). 2003;51:339–40.CrossRefGoogle Scholar
  8. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Planta Med. 2000;66:91–3.CrossRefPubMedGoogle Scholar
  9. Hung KC, Huang HJ, Wang YT, Lin AM. Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo. J Ethnopharmacol. 2016;194:522–9.CrossRefPubMedGoogle Scholar
  10. Kim DH, Jeon SJ, Son KH, Jung JW, Lee S, Yoon BH, Lee JJ, Cho YW, Cheong JH, Ko KH, Ryu JH. The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice. Neurobiol Learn Mem. 2007;87:536–46.CrossRefPubMedGoogle Scholar
  11. Kim DH, Kim S, Jeon SJ, et al. The effects of acute and repeated oroxylin A treatments on Abeta(25–35)-induced memory impairment in mice. Neuropharmacology. 2008;55:639.CrossRefPubMedGoogle Scholar
  12. Li J, Ding Y, Li XC, Ferreira D, Khan S, Smillie T, Khan IA. Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. J Nat Prod. 2009;72:983–7.CrossRefPubMedGoogle Scholar
  13. Liao JF, Wang HH, Chen MC, Chen CC, Chen CF. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. Planta Med. 1998;64:571–2.CrossRefPubMedGoogle Scholar
  14. Liu G, Rajesh N, Wang X, Zhang M, Wu Q, Li S, Chen B, Yao S. Identification of flavonoids in the stems and leaves of Scutellaria baicalensis Georgi. J Chromatogr B Analyt Technol Biomed Life Sci. 2011;879:1023–8.CrossRefPubMedGoogle Scholar
  15. Martin J, Dusek J. The Baikal scullcap (Scutellaria baicalensis Georgi) – a potential source of new drugs. Ceska Slov Farm. 2002;51:277–83.PubMedGoogle Scholar
  16. Park HG, Yoon SY, Choi JY, et al. Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis. Eur J Pharmacol. 2007;574:112–9.CrossRefPubMedGoogle Scholar
  17. Sigel E. Mapping of the benzodiazepine recognition site on GABA receptors. Curr Top Med Chem. 2000;2:833–9.CrossRefGoogle Scholar
  18. Wang H, Hui KM, Xu S, Chen Y, Wong JT, Xue H. Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex. Pharmazie. 2002;57:857–8.PubMedGoogle Scholar
  19. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med. 2003;9:74–8.PubMedGoogle Scholar
  20. Wu T, Wang Q, Jiang C, et al. Neo-clerodane diterpenoids from Scutellaria barbata with activity against Epstein-Barr virus lytic replication. J Nat Prod. 2015;78:500–9.CrossRefPubMedGoogle Scholar
  21. Wu XG, Wang SS, Miao H, Cheng JJ, Zhang SF, Shang YZ. Scutellaria barbata flavonoids alleviate memory deficits and neuronal injuries induced by composited Aβ in rats. Behav Brain Funct. 2016;12:33.CrossRefPubMedPubMedCentralGoogle Scholar
  22. Zhang Z, Lian XY, Li S, Stringer JL. Characterization of chemical ingredients and anticonvulsant activity of American skullcap (Scutellaria lateriflora). Phytomedicine. 2009;16:485–93.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Amritpal Singh Saroya
    • 1
  • Jaswinder Singh
    • 2
  1. 1.Herbal ConsultantMohaliIndia
  2. 2.Department of PharmacologySri Guru Ram Das Institute of Medical ScienceAmritsarIndia

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