Advertisement

Neuropharmacology of Curcumin

  • Amritpal Singh Saroya
  • Jaswinder Singh
Chapter

Abstract

Turmeric contains protein (6.3%), fat (5.1%), minerals (3.5%), carbohydrates (69.4%) and moisture (13.1%). The essential oil (5.8%) obtained by steam distillation of rhizomes has α-phellandrene or p-mentha-1,5-diene (1%), sabinene (0.6%), cineol (1%), borneol (0.5%), zingiberene (25%) and sesquiterpenes (53%) (Figs. 20.1, 20.2, 20.3, 20.4 and 20.5).

References

  1. Al-Omar FA, Nagi MN, Abdulgadir MM, Al Joni KS, Al-Majed AA. Immediate and delayed treatments with curcumin prevent forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus. Neurochem Res. 2006;31:611–8.CrossRefPubMedGoogle Scholar
  2. Fan YL, Li HC, Zhao W, Peng HH, Huang F, Jiang WH, Xu SY. Curcumin attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells via activation of the Akt signaling pathway. Neurochem Res. 2016;41:2425–32.CrossRefPubMedGoogle Scholar
  3. Ghoneim AI, Abdel-Naim AB, Khalifa AE, El-Denshary ES. Protective effects of curcumin against ischemia/reperfusion insult in rat forebrain. Pharmacol Res. 2002;46:273–9.CrossRefPubMedGoogle Scholar
  4. Huang Z, Zhong XM, Li ZY, Feng CR, Pan AJ, Mao QQ. Curcumin reverses corticosterone-induced depressive-like behaviour and decrease in brain BDNF levels in rats. Neurosci Lett. 2011;493:145–8.CrossRefPubMedGoogle Scholar
  5. Kumar P, Padi SS, Naidu PS, Kumar A. Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity. Methods Find Exp Clin Pharmacol. 2007;29:19–25.CrossRefPubMedGoogle Scholar
  6. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001;21:8370–7.CrossRefPubMedGoogle Scholar
  7. Lopresti AL, Drummond PD. Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: a randomised, double-blind, placebo-controlled study. J Affect Disord. 2017;207:188–96.CrossRefPubMedGoogle Scholar
  8. Motaghinejad M, Motevalian M, Fatima S, Hashemi H, Gholami M. Curcumin confers neuroprotection against alcohol-induced hippocampal neurodegeneration via CREB-BDNF pathway in rats. Biomed Pharmacother. 2017;87:721–40.CrossRefPubMedGoogle Scholar
  9. Rajakrishnan V, Viswanathan P, Rajasekharan KN, Menon VP. Neuroprotective role of curcumin from Curcuma longa on ethanol-induced brain damage. Phytother Res. 1999;13:571–4.CrossRefPubMedGoogle Scholar
  10. Shen JD, Wei Y, Li YJ, Qiao JY, Li YC. Curcumin reverses the depressive-like behaviour and insulin resistance induced by chronic mild stress. Metab Brain Dis. 2017;32:1163–72.CrossRefPubMedGoogle Scholar
  11. Shukla PK, Khanna VK, Khan MY, Srimal RC. Protective effect of curcumin against lead neurotoxicity in rat. Hum Exp Toxicol. 2003;22:653–8.CrossRefPubMedGoogle Scholar
  12. Singh S, Kumar P. Neuroprotective potential of curcumin in combination with piperine against 6-hydroxy dopamine induced motor deficit and neurochemical alterations in rats. Inflammopharmacology. 2017;25:69–79.CrossRefPubMedGoogle Scholar
  13. Veldman ER, Jia Z, Halldin C, Svedberg MM. Amyloid binding properties of curcumin analogues in Alzheimer’s disease post-mortem brain tissue. Neurosci Lett. 2016;630:183–8.CrossRefPubMedGoogle Scholar
  14. Wang R, Xu Y, Wu HL, Li YB, Li YH, Guo JB, Li XJ. The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors. Eur J Pharmacol. 2008;578:43–50.CrossRefPubMedGoogle Scholar
  15. Xu Y, Ku BS, Yao HY, Lin YH, Ma X, Zhang YH, Li XJ. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem Behav. 2005a;82:200–6.CrossRefPubMedGoogle Scholar
  16. Xu Y, Ku BS, Yao HY, Lin YH, Ma X, Zhang YH, Li XJ. The effects of curcumin on depressive-like behaviors in mice. Eur J Pharmacol. 2005b;518:40–6.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Amritpal Singh Saroya
    • 1
  • Jaswinder Singh
    • 2
  1. 1.Herbal ConsultantMohaliIndia
  2. 2.Department of PharmacologySri Guru Ram Das Institute of Medical ScienceAmritsarIndia

Personalised recommendations