Neuropharmacology of Nutritional Supplements
So far, few randomized trials are known for the role of folic acid or folate in depression. Folate added to antidepressant drug treatment offered limited evidence that folate has potential role in depression (Zhao et al. 2011). Some studies have reported utility of folic acid in treating depression (Watanabe et al. 2012) (Fig. 18.1).
- Alpert JE, Papakostas G, Mischoulon D, Worthington JJ, Petersen T, Mahal Y, et al. S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or non-response to selective serotonin reuptake inhibitors or venlafaxine. J Clin Psychopharmacol. 2004;24:661–4.CrossRefPubMedGoogle Scholar