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Neuropharmacology of Nutritional Supplements

  • Amritpal Singh Saroya
  • Jaswinder Singh
Chapter

Abstract

So far, few randomized trials are known for the role of folic acid or folate in depression. Folate added to antidepressant drug treatment offered limited evidence that folate has potential role in depression (Zhao et al. 2011). Some studies have reported utility of folic acid in treating depression (Watanabe et al. 2012) (Fig. 18.1).

References

  1. Alpert JE, Papakostas G, Mischoulon D, Worthington JJ, Petersen T, Mahal Y, et al. S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or non-response to selective serotonin reuptake inhibitors or venlafaxine. J Clin Psychopharmacol. 2004;24:661–4.CrossRefPubMedGoogle Scholar
  2. Beckmann H, Ludolph E. DL-phenylalanine as an antidepressant. Open study (author’s transl). Arzneimittelforschung. 1978;28:1283–4.PubMedPubMedCentralGoogle Scholar
  3. Beckmann H, Strauss MA, Ludolph E. Dl-phenylalanine in depressed patients: an open study. J Neural Transm. 1977;41:123–34.CrossRefPubMedGoogle Scholar
  4. Beckmann H, Athen D, Olteanu M, Zimmer R. DL-phenylalanine versus imipramine: a double-blind controlled study. Arch Psychiatr Nervenkr (1970). 1979;227:49–58.CrossRefGoogle Scholar
  5. Chavez M. SAMe: S-Adenosylmethionine. Am J Health Syst Pharm. 2000;57:119–23.PubMedGoogle Scholar
  6. Delle CR, Pancheri P, Scapicchio P. Efficacy and tolerability of oral and intramuscular S-adenosyl-L- methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies. Am J Clin Nutr. 2002;76:1172S–6.CrossRefGoogle Scholar
  7. Galizia I, Oldani L, Macritchie K, Amari E, Dougall D, Jones TN, Lam RW, Massei GJ, Yatham LN, Young AH. S-adenosyl methionine (SAMe) for depression in adults. Cochrane Database Syst Rev. 2016;10:CD011286.PubMedGoogle Scholar
  8. Mischoulon D, Alpert JE, Arning E, Bottiglieri T, Fava M, Papakostas GI. Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder. J Clin Psychiatry. 2012;73:843–8.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Soh NL, Walter G. Tryptophan and depression: can diet alone be the answer? Acta Neuropsychiatrica. 2011;1:3–11.CrossRefGoogle Scholar
  10. Watanabe H, Ishida S, Konno Y, Matsumoto M, Nomachi S, Masaki K, Okayama H, Nagai Y. Impact of dietary folate intake on depressive symptoms in young women of reproductive age. J Midwifery Womens Health. 2012;57:43–8.CrossRefPubMedPubMedCentralGoogle Scholar
  11. Zhao G, Ford ES, Li C, Greenlund KJ, Croft JB, Balluz LS. Use of folic acid and vitamin supplementation among adults with depression and anxiety: a cross-sectional, population-based survey. Nutr J. 2011;10:102.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Amritpal Singh Saroya
    • 1
  • Jaswinder Singh
    • 2
  1. 1.Herbal ConsultantMohaliIndia
  2. 2.Department of PharmacologySri Guru Ram Das Institute of Medical ScienceAmritsarIndia

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