Endophytes: A Gold Mine of Enzyme Inhibitors

  • Vineet Meshram
  • Kanika Uppal
  • Mahiti GuptaEmail author


Ever since the landmark discovery of paclitaxel from endophytic Taxomyces andreanae, plant endophytes have been the fountainheads of bioactive secondary metabolites with potential application in medicine, agriculture, and food industry. In the last two decades, lead molecules with antimicrobial, anticancer, antioxidant, and anti-inflammatory properties have been successfully discovered from endophytic microorganisms. Bioprospecting endophytes for enzyme inhibitors has been an important facet of endophytic research. Several enzyme inhibitors like altenusin, huperzine, camptothecin, and podophyllotoxin have been successfully isolated from endophytic microorganisms. The current chapter partially embodies the research progress on endophytic microorganisms for producing bioactive enzyme inhibitors and their possible use in pharmaceutical industries.


Bioactive compounds Endophytes Enzyme inhibitors Plant-microbe interaction 



Authors dedicate this book chapter to Dr. Kamlesh Kumar Shukla, Assistant Professor, School of Studies in Biotechnology, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, India, for his constant support and guidance. Authors appreciate the kind help of Dr. Ramandeep Kaur, Assistant Professor, Department of Chemistry, Govind National College, Narangwal, Punjab, India, in preparation of structures of enzyme inhibitors from endophytes.


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Plant Pathology and Weed Research, The Volcani CentreAgriculture Research OrganizationRishon-LeTsiyonIsrael
  2. 2.Department of BiochemistryDAV UniversityJalandharIndia
  3. 3.Department of Cardiology/Pulmonary HypertensionUniversity of Minnesota Clinics and Surgery CenterMinneaoplisUSA
  4. 4.Department of Biotechnology, School of Biotechnology and BiosciencesLovely Professional UniversityPhagwaraIndia

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