Targeting Quorum Sensing Mediated Staphylococcus aureus Biofilms: A Proteolytic Approach
Staphylococcus aureus infects human through biofilm formed by the process of quorum sensing. Biofilm confers this human pathogen with high resistance to antibiotics. The inhibition of biofilm forming process or dispersal of already formed biofilm can be the potential targets for treating the diseases. Since, the biofilm is made up of exopolysaccharides, proteins and lipids, the action of proteases can hydrolyse the protein component and disrupt the biofilm matrix. Consequently the bacterium so exposed can be eliminated by low doses of antibacterials.
KeywordsQuorum sensing Proteases Bdellovibrio Staphylococcus Biofilms
We are thankful to the Director of CSIR – Institute of Genomics and Integrative Biology (CSIR-IGIB), and CSIR-HRD (ES Scheme No. 21(1022)/16/EMR-II) for providing the necessary funds, facilities and moral support. Authors are also thankful to Academy of Scientific & Innovative Research (AcSIR), New Delhi and University Grants Commission (JP). This work was supported by Brain Pool grant (NRF-2018H1D3A2001756) by National Research Foundation of Korea (NRF) to work at Konkuk University.
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