Combating Staphylococcal Infections Through Quorum Sensing Inhibitors

  • Nishant Kumar
  • Hansita Gupta
  • Neha Dhasmana
  • Yogendra Singh


Staphylococcus aureus is a clinically important pathogen mainly causing hospital borne infections. These bacterial infections range from mild skin infections to serious health threats like endocarditis, osteomyelitis, and pneumonia. Few strains have developed resistance against antibiotics used to treat S. aureus infections and are termed as Methicillin Resistant S. aureus strains. The pathogen releases Auto Inducing Peptides to establish cell density dependent inter-cell communication, also known as quorum sensing (QS). QS results in the expression of accessory gene regulator system. It causes successful biofilm formation and enhanced expression of toxins. QS mediated biofilm formation provides an additional resistance against the antibiotics used. An innovative therapeutic approach has been studied vastly in last decade to deal with severe infections using specific QS inhibitors (QSIs). This chapter comprehensively describes the QSIs studied to control the infections caused by S. aureus strains.


Agr system Staphylococcus aureus Biofilm Inhibitors Quorum sensing RAP/TRAP 



This work is supported by J C Bose Fellowship (SERB) to YS and Research Grant by University of Delhi. NK is UGC-SRF. HG is Masters of Science in Zoology from University of Delhi. ND is Shyama Prasad Mukherjee Fellow (CSIR-SRF) and Fulbright-Nehru Doctoral Fellow (2015–16) at NIAID NIH.

Author Information

The authors declare no competing financial interests. Correspondence and requests for materials should be addressed to YS (


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Nishant Kumar
    • 1
    • 2
  • Hansita Gupta
    • 3
  • Neha Dhasmana
    • 1
    • 2
  • Yogendra Singh
    • 3
    • 2
  1. 1.Allergy and Infectious DiseasesCSIR – Institute of Genomics and Integrative BiologyDelhiIndia
  2. 2.Academy of Scientific & Innovative Research (AcSIR)New DelhiIndia
  3. 3.Department of ZoologyUniversity of DelhiDelhiIndia

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