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Integrative Omics for Interactomes

  • Debangana Chakravorty
  • Krishnendu Banerjee
  • Sudipto Saha
Chapter

Abstract

Single-layer omics provide limited insight, whereas integrated multi-omics layers allow understanding of their combined influence on the complex biological process. The integrative omics approach has been initially applied to cancer research and later used in understanding host-pathogen interactions and pluripotency regulatory networks in stem cells. Here, different multi-omics layers along with databases and tools specific for multiple data integration, visualization, and integrated network modeling are described. In summary, this chapter focuses on integrative analysis of different multi-omics layers and modeling of interactomes to identify robust biomarkers and biological processes associated with diseases.

Keywords

Multi-omics Protein-protein interactions TCGA CPTAC Integrative analysis 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Debangana Chakravorty
    • 1
  • Krishnendu Banerjee
    • 1
  • Sudipto Saha
    • 1
  1. 1.Bioinformatics CentreBose InstituteKolkataIndia

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