Use of Indian Indigenous Fruits in Cancer Prevention and Treatment

  • Manjeshwar Shrinath Baliga
  • Suresh Rao
  • Pratima Rao
  • Krishnaprasad
  • Sanath Kumar Hegde
  • Kandel Codi Jalaluddin Akbar
  • Soniya Abraham
  • Thomas George
  • Princy Louis Palatty


Cancer is the world’s second leading cause of death, and it will supersede the cardiovascular diseases in near future. The use of natural, synthetic, or biological agents to reverse or suppress either the initial phases of carcinogenesis or the progression of premalignant cells to invasive disease is being recognized as an important means of reducing the cancer incidence. In this regard, the dietary agents with beneficial effects like free radical scavenging, antioxidant, and immunomodulatory are being recognized as useful in the prevention of cancer. India is well known for several biodiverse regions and is a home for many fruiting trees having beneficial biological effects. In this chapter, the anticancer properties of certain indigenous fruits, namely, mango (Mangifera indica), Indian gooseberry (Emblica officinalis or Phyllanthus emblica), black plum (Eugenia jambolana or Syzygium jambolana), kokum (Garcinia indica or Brindonia indica), and stone apple or bael (Aegle marmelos), have been summarized. The usefulness of these fruits in cancer prevention/treatment and the underlying mechanisms mediated by the phytochemicals present in these fruits are also emphasized.


Aegle marmelos Chemoprevention Emblica officinalis Eugenia jambolana Garcinia indica Mangifera indica Phyllanthus emblica 


  1. Agrawal A, Jahan S, Goyal PK (2011) Chemically induced skin carcinogenesis in mice and its prevention by Aegle marmelos (an Indian medicinal plant) fruit extract. J Environ Pathol Toxicol Oncol 30:251–259CrossRefPubMedGoogle Scholar
  2. Ahmad A, Wang Z, Ali R, Maitah MY, Kong D, Banerjee S, Padhye S, Sarkar FH (2010) Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells. J Cell Biochem 109:1134–1141PubMedPubMedCentralGoogle Scholar
  3. Ahmad A, Wang Z, Wojewoda C, Ali R, Kong D, Maitah MY, Banerjee S, Bao B, Padhye S, Sarkar FH (2011) Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF- kappaB signaling. Front Biosci 3:1483–1492Google Scholar
  4. Ahmad A, Sarkar SH, Bitar B, Ali S, Aboukameel A, Sethi S, Li Y, Bao B, Kong D, Banerjee S, Padhye SB, Sarkar FH (2012a) Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells. Mol Cancer Ther 11:2193–2201CrossRefPubMedGoogle Scholar
  5. Ahmad A, Sarkar SH, Aboukameel A, Ali S, Biersack B, Seibt S, Li Y, Bao B, Kong D, Banerjee S, Schobert R, Padhye SB, Sarkar FH (2012b) Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling. Carcinogenesis 33:2450–2456CrossRefPubMedGoogle Scholar
  6. Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB (2008) Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 25:2097–2116CrossRefPubMedPubMedCentralGoogle Scholar
  7. Aqil F, Gupta A, Munagala R, Jeyabalan J, Kausar H, Sharma RJ, Singh IP, Gupta RC (2012) Antioxidant and antiproliferative activities of anthocyanin/ellagitannin-enriched extracts from Syzygium cumini L. (Jamun, the Indian Blackberry). Nutr Cancer 64:428–438CrossRefPubMedPubMedCentralGoogle Scholar
  8. Are C, Colburn L, Rajaram S, Vijayakumar M (2010) Disparities in cancer care between the United States of America and India and opportunities for surgeons to lead. J Surg Oncol 102:100–105CrossRefPubMedGoogle Scholar
  9. Arif M, Pradhan SK, Thanuja GR, Vedamurthy BM, Agrawal S, Dasgupta D, Kundu TK (2009) Mechanism of p300 specific histone acetyltransferase inhibition by small molecules. J Med Chem 52:267–277CrossRefPubMedGoogle Scholar
  10. Balasubramanyam K, Altaf M, Varier RA, Swaminathan V, Ravindran A, Sadhale PP, Kundu TK (2004) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem 279:33716–33726CrossRefPubMedGoogle Scholar
  11. Baliga MS (2011) Anticancer, chemopreventive and radioprotective potential of black plum (Eugenia jambolana lam.). Asian Pac J Cancer Prev 12:3–15PubMedPubMedCentralGoogle Scholar
  12. Baliga MS, Dsouza JJ (2011) Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. Eur J Cancer Prev 20:225–239CrossRefPubMedGoogle Scholar
  13. Baliga MS, Dsouza JJ, Haniadka R, Arora R (2009) Indian vegetarian diet and cancer prevention. In: Watson P (ed) Bioactive foods and extracts: cancer treatment and prevention. Taylor and Francis, Boca Raton, pp 465–493Google Scholar
  14. Baliga MS, Bhat HP, Baliga BRV, Wilson R, Palatty PL (2011a) Phytochemistry, traditional uses and pharmacology of Eugenia jambolana Lam. (black plum): a review. Food Res Int 44:1776–1789CrossRefGoogle Scholar
  15. Baliga MS, Bhat HP, Pai RJ, Boloor R, Palatty PL (2011b) The chemistry and medicinal uses of the underutilized Indian fruit tree Garcinia indica Choisy (kokum): a review. Food Res Int 44:1790–1799CrossRefGoogle Scholar
  16. Baliga MS, Bhat HP, Joseph N, Fazal F (2011c) Phytochemistry and medicinal uses of the bael fruit (Aegle marmelos Correa): a concise review. Food Res Int 44:1768–1775CrossRefGoogle Scholar
  17. Baliga MS, Rai MP, Thilakchanda KR, Rai MP, Rao S, Venkatesh P (2013) Aegle marmelos (L.) Correa (Bael) and its phytochemicals in the treatment and prevention of cancer. Integr Cancer Ther 12:187–196CrossRefPubMedGoogle Scholar
  18. Baliga MS, Fernandes S, Thilakchand KR, D’souza P, Rao S (2013a) Scientific validation of the antidiabetic effects of Syzygium jambolanum DC (black plum), a traditional medicinal plant of India. J Altern Compl Med 19:191–197CrossRefGoogle Scholar
  19. Banu SM, Selvendiran K, Singh JP, Sakthisekaran D (2004) Protective effect of Emblica officinalis ethanolic extract against 7,12-dimethylbenz(a) anthracene (DMBA) induced genotoxicity in Swiss albino mice. Hum Exp Toxicol 23:527–531CrossRefPubMedGoogle Scholar
  20. Barh D, Viswanathan G (2008) Syzygium cumini inhibits growth and induces apoptosis in cervical cancer cell lines: a primary study. Ecancermedicalscience 2:83. Scholar
  21. Barone E, Calabrese V, Mancuso C (2009) Ferulic acid and its therapeutic potential as a hormetin for age-related diseases. Biogerontology 10:97–108CrossRefPubMedGoogle Scholar
  22. Bell C, Hawthorne S (2008) Ellagic acid, pomegranate and prostate cancer-a mini review. J Pharm Pharmacol 60:139–144CrossRefPubMedGoogle Scholar
  23. Biswas S, Talukder G, Sharma A (1998) Protection against cytotoxic effects of arsenic by dietary supplementation with crude extract of Emblica officinalis fruit. Phytother Res 13:513–516CrossRefGoogle Scholar
  24. Carranco Jáuregui ME, Calvo Carrillo Mde L, Romo FP (2011) Carotenoids and their antioxidant function: a review. Arch Latinoam Nutr 61:233–241PubMedPubMedCentralGoogle Scholar
  25. Chaturvedi PK, Bhui K, Shukla Y (2008) Lupeol connotations for chemoprevention. Cancer Lett 263:1–13CrossRefPubMedGoogle Scholar
  26. Chen AY, Chen YC (2013) A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem 138:2099–2107CrossRefPubMedGoogle Scholar
  27. Chen PN, Chu SC, Chiou HL, Kuo WH, Chiang CL, Hsieh YS (2006) Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. Cancer Lett 235:248–259CrossRefPubMedGoogle Scholar
  28. Chen KH, Lin BR, Chien CT, Ho CH (2011) Emblica officinalis Gaertn. attentuates N-nitrosodiethylamine-induced apoptosis, autophagy, and inflammation in rat livers. J Med Food 14:746–755CrossRefPubMedGoogle Scholar
  29. Chen X, Zhang X, Lu Y, Shim JY, Sang S, Sun Z, Chen X (2012) Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol. Nutr Cancer 64:1211–1218CrossRefPubMedPubMedCentralGoogle Scholar
  30. Cheng AC, Tsai ML, Liu CM, Lee MF, Nagabhushanam K, Ho CT, Pan MH (2010) Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis. Food Funct 1:301–307CrossRefPubMedGoogle Scholar
  31. Colomer R, Menéndez JA (2006) Mediterranean diet, olive oil and cancer. Clin Transl Oncol 8:15–21CrossRefPubMedGoogle Scholar
  32. Cooke D, Schwarz M, Boocock D, Winterhalter P, Steward WP, Gescher AJ, Marczylo TH (2006) Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis – relationship with tissue anthocyanin levels. Int J Cancer 119:2213–2220CrossRefPubMedGoogle Scholar
  33. Dajas F (2012) Life or death: neuroprotective and anticancer effects of quercetin. J Ethnopharmacol 143:383–396CrossRefPubMedGoogle Scholar
  34. Dhir H, Roy AK, Sharma A, Talukder G (1990) Modification of clastogenicity of lead and aluminium in mouse bone marrow cells by dietary ingestion of Phyllanthus emblica fruit extract. Mutat Res 241:305–312CrossRefPubMedGoogle Scholar
  35. Dhir H, Agarwal K, Sharma A, Talukder G (1991) Modifying role of Phyllanthus emblica and ascorbic acid against nickel clastogenicity in mice. Cancer Lett 59:9–18CrossRefPubMedGoogle Scholar
  36. Ding M, Feng R, Wang SY, Bowman L, Lu Y, Qian Y, Castranova V, Jiang BH, Shi X (2006) Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. J Biol Chem 281:17359–17368CrossRefPubMedGoogle Scholar
  37. du Plessis-Stoman D, du Preez J, van de Venter M (2011) Combination treatment with oxaliplatin and mangiferin causes increased apoptosis and downregulation of NFκB in cancer cell lines. Afr J Tradit Compl Altern Med 8:177–184Google Scholar
  38. Elisia I, Kitts DD (2008) Anthocyanins inhibit peroxyl radical-induced apoptosis in Caco-2 cells. Mol Cell Biochem 312:139–145CrossRefPubMedPubMedCentralGoogle Scholar
  39. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Can 127:2893–2917CrossRefGoogle Scholar
  40. Fimognari C, Lenzi M, Hrelia P (2008) Chemoprevention of cancer by isothiocyanates and anthocyanins: mechanisms of action and structure-activity relationship. Curr Med Chem 15:440–447CrossRefPubMedGoogle Scholar
  41. Ghosh A, Sharma A, Talukder G (1992) Relative protection given by extract of Phyllanthus emblica fruit and an equivalent amount of vitamin C against a known clastogen-caesium chloride. Food Chem Toxicol 30:865–869CrossRefPubMedGoogle Scholar
  42. Gibellini L, Pinti M, Nasi M, Montagna JP, De Biasi S, Roat E, Bertoncelli L, Cooper EL, Cossarizza A (2011) Quercetin and cancer chemoprevention. Evidence-Based Compl Altern Med 2011:591356. Scholar
  43. González-Sarrías A, Larrosa M, Tomás-Barberán FA, Dolara P, Espín JC (2010) NF-kappaB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts. Br J Nutr 104:503–512CrossRefPubMedGoogle Scholar
  44. Goyal PK, Verma P, Sharma P (2010) Evaluation of anti-cancer and anti-oxidative potential of Syzygium cumini against benzo[a]pyrene (BaP) induced gastric carcinogenesis in mice. Asian Pac J Cancer Prev 11:753–758PubMedGoogle Scholar
  45. Haque R, Bin-Hafeez B, Ahmad I, Parvez S, Pandey S, Raisuddin S (2001) Protective effects of Emblica officinalis Gaertn. in cyclophosphamide-treated mice. Hum Exp Toxicol 20:643–650CrossRefPubMedGoogle Scholar
  46. Hari Kumar KB, Sabu MC, Lima PS, Kuttan R (2004) Modulation of haematopoetic system and antioxidant enzymes by Emblica officinalis gaertn and its protective role against gamma-radiation induced damages in mice. J Radiat Res 45:549–555CrossRefPubMedGoogle Scholar
  47. Heber D (2008) Multitargeted therapy of cancer by ellagitannins. Cancer Lett 269:262–268CrossRefPubMedGoogle Scholar
  48. Hou DX (2003) Potential mechanisms of cancer chemoprevention by anthocyanins. Curr Mol Med 3:149–159CrossRefPubMedGoogle Scholar
  49. Irigaray P, Newby JA, Clapp R, Hardell L, Howard V, Montagnier L, Epstein S, Belpomme D (2007) Lifestyle-related factors and environmental agents causing cancer: an overview. Biomed Pharmacother 61:640–658CrossRefPubMedGoogle Scholar
  50. Jaganathan SK, Supriyanto E (2012) Antiproliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells. Molecules 17:6290–6304CrossRefPubMedGoogle Scholar
  51. Jagetia GC, Baliga MS (2002) Syzygium cumini (Jamun) reduces the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes: a preliminary study. Toxicol Lett 132:19–25CrossRefPubMedGoogle Scholar
  52. Jagetia GC, Baliga MS (2003) Evaluation of the radioprotective effect of the leaf extract of Syzygium cumini (Jamun) in mice exposed to a lethal dose of gamma-irradiation. Nahrung 47:181–185CrossRefPubMedGoogle Scholar
  53. Jagetia GC, Baliga MS (2005) Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study. Phytomedicine 12:209–215CrossRefPubMedGoogle Scholar
  54. Jagetia GC, Venkatesha VA (2005) Effect of mangiferin on radiation-induced micronucleus formation in cultured human peripheral blood lymphocytes. Environ Mol Mutagen 46:12–21CrossRefPubMedGoogle Scholar
  55. Jagetia GC, Venkatesh P, Baliga MS (2004) Fruit extract of Aegle marmelos protects mice against radiation-induced lethality. Integr Cancer Ther 3:323–332CrossRefPubMedGoogle Scholar
  56. Jagetia GC, Baliga MS, Venkatesh P (2005a) Influence of seed extract of Syzygium cumini (Jamun) on mice exposed to different doses of gamma-radiation. J Radiat Res 46:59–65CrossRefPubMedGoogle Scholar
  57. Jagetia GC, Venkatesh P, Baliga MS (2005b) Aegle marmelos (L.) Correa inhibits the proliferation of transplanted Ehrlich ascites carcinoma in mice. Biol Pharm Bull 28:58–64CrossRefPubMedGoogle Scholar
  58. Jindal A, Soyal D, Sharma A, Goyal PK (2009) Protective effect of an extract of Emblica officinalis against radiation-induced damage in mice. Integr Cancer Ther 8:98–105CrossRefPubMedGoogle Scholar
  59. Jose JK, Kuttan G, Kuttan R (2001) Antitumour activity of Emblica officinalis. J Ethnopharmacol 75:65–69CrossRefPubMedGoogle Scholar
  60. Kausar H, Jeyabalan J, Aqil F, Chabba D, Sidhana J, Singh IP, Gupta RC (2012) Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells. Cancer Lett 325:54–62CrossRefPubMedGoogle Scholar
  61. Khan MT, Lampronti I, Martello D, Bianchi N, Jabbar S, Choudhuri MS, Datta BK, Gambari R (2002) Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: effects on in vitro cell growth of human tumor cell lines. Int J Oncol 21:187–192PubMedGoogle Scholar
  62. Khandelwal S, Shukla LJ, Shanker R (2002) Modulation of acute cadmium toxicity by Emblica officinalis fruit in rat. Indian J Exp Biol 40:564–570PubMedGoogle Scholar
  63. Kocic B, Filipovic S, Nikolic M, Petrovic B (2011) Effects of anthocyanins and anthocyanin-rich extracts on the risk for cancers of the gastrointestinal tract. J BUON 16:602–608PubMedGoogle Scholar
  64. Krishnaveni M, Mirunalini S (2012) Chemopreventive efficacy of Phyllanthus emblica L. (amla) fruit extract on 7,12-dimethylbenz(a)anthracene induced oral carcinogenesis-a dose-response study. Environ Toxicol Pharmacol 34:801–810CrossRefPubMedGoogle Scholar
  65. Lambertini E, Piva R, Khan MT, Lampronti I, Bianchi N, Borgatti M, Gambari R (2004) Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor alpha gene. Int J Oncol 24:419–423PubMedGoogle Scholar
  66. Lampronti I, Martello D, Bianchi N, Borgatti M, Lambertini E, Piva R, Jabbar S, Choudhuri MS, Khan MT, Gambari R (2003) In vitro antiproliferative effects on human tumor cell lines of extracts from the Bangladeshi medicinal plant Aegle marmelos Correa. Phytomedicine 10:300–308CrossRefPubMedGoogle Scholar
  67. Larrosa M, González-Sarrías A, García-Conesa MT, Tomás-Barberán FA, Espín JC (2006) Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities. J Agric Food Chem 54:1611–1620CrossRefPubMedGoogle Scholar
  68. Lei J, Zhou C, Hu H, Hu L, Zhao M, Yang Y, Chuai Y, Ni J, Cai J (2012) Mangiferin aglycone attenuates radiation-induced damage on human intestinal epithelial cells. J Cell Biochem 113:2633–2642CrossRefPubMedGoogle Scholar
  69. Li H, Wang Z, Liu Y (2003) Review in the studies on tannins activity of cancer prevention and anticancer. Zhong Yao Cai 26:444–448PubMedPubMedCentralGoogle Scholar
  70. Li L, Adams LS, Chen S, Killian C, Ahmed A, Seeram NP (2009) Eugenia jambolana Lam. berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. J Agric Food Chem 57:826–831CrossRefPubMedPubMedCentralGoogle Scholar
  71. Liao CH, Ho CT, Lin JK (2005) Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytes. Biochem Biophys Res Commun 329:1306–1314CrossRefPubMedGoogle Scholar
  72. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K (2000) Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. New Eng J Med 343:78–85CrossRefPubMedGoogle Scholar
  73. Mantelingu K, Reddy BA (2007) Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chem Biol 14:645–657CrossRefPubMedGoogle Scholar
  74. Matkowski A, Kuss P, Goralska E, Wozniak D (2013) Mangiferin-a bioactive xanthonoid, not only from mango and not just antioxidant. Mini Rev Med Chem 13:439–455PubMedGoogle Scholar
  75. Matsumoto K, Akao Y, Kobayashi E, Ito T, Ohguchi K, Tanaka T, Iinuma M, Nozawa Y (2003) Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines. Biol Pharm Bull 26:569–571CrossRefPubMedGoogle Scholar
  76. Mendoza EE, Burd R (2011) Quercetin as a systemic chemopreventative agent: structural and functional mechanisms. Mini Rev Med Chem 11:1216–1221PubMedGoogle Scholar
  77. Moongkarndi P, Kosem N, Luanratana O, Jongsomboonkusol S, Pongpan N (2004) Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. Fitoterapia 75:375–377CrossRefPubMedGoogle Scholar
  78. Morton JF (1987) Fruits of warm climates. Creative Resources Systems, WintervilleGoogle Scholar
  79. Mucci LA, Wedren S, Tamimi RM, Trichopoulos D, Adami HO (2001) The role of gene-environment interaction in the aetiology of human cancer: examples from cancers of the large bowel, lung and breast. J Intern Med 249:477–493CrossRefPubMedGoogle Scholar
  80. Nandi P, Talukder G, Sharma A (1997) Dietary chemoprevention of clastogenic effects of 3,4-benzo(a) pyrene by Emblica officinalis Gaertn. fruit extract. Br J Cancer 76:1279–1283CrossRefPubMedPubMedCentralGoogle Scholar
  81. Nepka C, Asprodini E, Kouretas D (1999) Tannins, xenobiotic metabolism and cancer chemoprevention in experimental animals. Eur J Drug Metab Pharmacokinet 24:183–189CrossRefPubMedGoogle Scholar
  82. Noratto GD, Bertoldi MC, Krenek K, Talcott ST, Stringheta PC, Mertens-Talcott SU (2010) Anticarcinogenic effects of polyphenolics from mango (Mangifera indica) varieties. J Agric Food Chem 58:4104–4112CrossRefPubMedGoogle Scholar
  83. Oike T, Ogiwara H, Torikai K, Nakano T, Yokota J, Kohno T (2012) Garcinol, a histone acetyltransferase inhibitor, radiosensitizes cancer cells by inhibiting non-homologous end joining. Int J Radiat Oncol Biol Phys 84:815–821CrossRefPubMedGoogle Scholar
  84. Ow YY, Stupans I (2003) Gallic acid and gallic acid derivatives: effects on drug metabolizing enzymes. Curr Drug Metab 4:241–248CrossRefPubMedGoogle Scholar
  85. Pan MH, Chang WL, Lin-Shiau SY, Ho CT, Lin JK (2001) Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells. J Agric Food Chem 49:1464–1474CrossRefPubMedGoogle Scholar
  86. Parasramka MA, Gupta SV (2011) Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cells. Nutr Cancer 63:456–465CrossRefPubMedGoogle Scholar
  87. Parmar J, Sharma P, Verma P, Goyal PK (2010) Chemopreventive action of Syzygium cumini on DMBA-induced skin papillomagenesis in mice. Asian Pac J Cancer Prev 11:261–265PubMedPubMedCentralGoogle Scholar
  88. Parmar J, Sharma P, Verma P (2011) Elimination of deleterious effects of DMBA-induced skin carcinogenesis in mice by Syzygium cumini seed extract. Integr Cancer Ther 10(3):289–297CrossRefPubMedGoogle Scholar
  89. Percival SS, Talcott ST, Chin ST, Mallak AC, Lounds-Singleton A, Pettit-Moore J (2006) Neoplastic transformation of BALB/3T3 cells and cell cycle of HL-60 cells are inhibited by mango (Mangifera indica L.) juice and mango juice extracts. J Nutr 136:1300–1304CrossRefPubMedGoogle Scholar
  90. Petrova A, Davids LM, Rautenbach MJL (2011) Photoprotection by honeybush extracts, hesperidin and mangiferin against UVBinduced skin damage in SKH-1 mice. J Photochem Photobiol B 103:126–139CrossRefPubMedGoogle Scholar
  91. Pinmai K, Chunlaratthanabhorn S, Ngamkitidechakul C, Soonthornchareon N, Hahnvajanawong C (2008) Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents: doxorubicin and cisplatin against human hepatocellular carcinoma and lung cancer cells. World J Gastroenterol 14:1491–1497CrossRefPubMedPubMedCentralGoogle Scholar
  92. Prasad S, Kalra N, Shukla Y (2007) Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice. Mol Nutr Food Res 51:352–359CrossRefPubMedGoogle Scholar
  93. Prasad S, Kalra N, Shukla Y (2008a) Induction of apoptosis by lupeol and mango extract in mouse prostate and LNCaP cells. Nutr Can 60:120–130CrossRefGoogle Scholar
  94. Prasad S, Kalra N, Singh M, Shukla Y (2008b) Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice. Asian J Androl 10:313–318CrossRefPubMedGoogle Scholar
  95. Raffelsbauer D (2012) Is cancer preventable. A literature review. Med Writ 21:44–50CrossRefGoogle Scholar
  96. Rajendran P, Ekambaram G, Sakthisekaran D (2008a) Protective role of mangiferin against Benzo(a) pyrene induced lung carcinogenesis in experimental animals. Biol Pharm Bull 31:1053–1058CrossRefPubMedGoogle Scholar
  97. Rajendran P, Ekambaram G, Sakthisekaran D (2008b) Effect of mangiferin on benzo(a) pyrene induced lung carcinogenesis in experimental Swiss albino mice. Nat Prod Res 22:672–680CrossRefPubMedGoogle Scholar
  98. Rajendran P, Ekambaram G, Sakthisekaran D (2008c) Cytoprotective effect of mangiferin on benzo(a) pyrene-induced lung carcinogenesis in swiss albino mice. Basic Clin Pharmacol Toxicol 103:137–142CrossRefPubMedGoogle Scholar
  99. Rajendran P, Ekambaram G, Magesh V, Sakthisekaran D (2008d) Chemopreventive efficacy of mangiferin against benzo(a) pyrene induced lung carcinogenesis in experimental animals. Environ Toxicol Pharmacol 26:278–282CrossRefPubMedGoogle Scholar
  100. Rajeshkumar NV, Pillai MR, Kuttan R (2003) Induction of apoptosis in mouse and human carcinoma cell lines by Emblica officinalis polyphenols and its effect on chemical carcinogenesis. J Exp Clin Cancer Res 22:201–212PubMedPubMedCentralGoogle Scholar
  101. Riboli E, Norat T (2003) Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 78:S559–S569CrossRefGoogle Scholar
  102. Sai Ram M, Neetu D, Deepti P, Vandana M, Ilavazhagan G, Kumar D, Selvamurthy W (2003) Cytoprotective activity of amla (Emblica officinalis) against chromium (VI) induced oxidative injury in murine macrophages. Phytother Res 17:430–433CrossRefPubMedGoogle Scholar
  103. Saleem M (2009) A novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Lett 285:109–115CrossRefPubMedPubMedCentralGoogle Scholar
  104. Sancheti G, Jindal A, Kumari R, Goyal PK (2005) Chemopreventive action of Emblica officinalis on skin carcinogenesis in mice. Asian Pac J Cancer Prev 6:197–201PubMedPubMedCentralGoogle Scholar
  105. Shah KA, Patel MB, Patel RJ, Parmar PK (2010) Mangifera indica (Mango). Pharmacogn Rev 4:42–48CrossRefPubMedPubMedCentralGoogle Scholar
  106. Sharma N, Trikha P, Athar M, Raisuddin S (2000) Inhibitory effect of Emblica officinalis on the in vivo clastogenicity of benzo[a]pyrene and cyclophosphamide in mice. Hum Exp Toxicol 19:377–384CrossRefPubMedGoogle Scholar
  107. Sharma M, Li L, Celver J, Killian C, Kovoor A, Seeram NP (2010) Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling. J Agric Food Chem 58:3965–3969CrossRefPubMedPubMedCentralGoogle Scholar
  108. Sharoni Y, Linnewiel-Hermoni K, Khanin M, Salman H, Veprik A, Danilenko M, Levy J (2012) Carotenoids and apocarotenoids in cellular signaling related to cancer: a review. Mol Nutr Food Res 56:259–269CrossRefPubMedGoogle Scholar
  109. Siddique HR, Saleem M (2011) Beneficial health effects of lupeol triterpene: a review of preclinical studies. Life Sci 88:285–293CrossRefPubMedGoogle Scholar
  110. Singh I, Sharma A, Nunia V, Goyal PK (2005) Radioprotection of swiss albino mice by Emblica officinalis. Phytother Res 19:444–446CrossRefPubMedGoogle Scholar
  111. Srinivasan M, Sudheer AR, Menon VP (2007) Ferulic acid: therapeutic potential through its antioxidant property. J Clin Biochem Nutr 40:92–100CrossRefPubMedPubMedCentralGoogle Scholar
  112. Sultana S, Ahmed S, Sharma S, Jahangir T (2004) Emblica officinalis reverses thioacetamide-induced oxidative stress and early promotional events of primary hepatocarcinogenesis. J Pharm Pharmacol 56:1573–1579CrossRefPubMedGoogle Scholar
  113. Sultana S, Ahmed S, Jahangir T (2008) Emblica officinalis and hepatocarcinogenesis: a chemopreventive study in Wistar rats. J Ethnopharmacol 118:1–6CrossRefPubMedGoogle Scholar
  114. Sumantran VN, Boddul S, Koppikar SJ, Dalvi M, Wele A, Gaire V, Wagh UV (2007) Differential growth inhibitory effects of W. somnifera root and E. officinalis fruits on CHO cells. Phytother Res 21:496–499CrossRefPubMedGoogle Scholar
  115. Tanaka T, Kohno H, Shimada R, Kagami S, Yamaguchi F, Kataoka S, Ariga T, Murakami A, Koshimizu K, Ohigashi H (2000) Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats. Carcinogenesis 21:1183–1189CrossRefPubMedGoogle Scholar
  116. Tanaka T, Shnimizu M, Moriwaki H (2012) Cancer chemoprevention by carotenoids. Molecules 17:3202–3242CrossRefPubMedGoogle Scholar
  117. Touaibia M, Jean-François J, Doiron J (2011) Caffeic acid, a versatile pharmacophore: an overview. Mini Rev Med Chem 11:695–713CrossRefPubMedGoogle Scholar
  118. Wang LS, Stoner GD (2008) Anthocyanins and their role in cancer prevention. Cancer Lett 269:281–290CrossRefPubMedPubMedCentralGoogle Scholar
  119. Wattanapitayakul SK, Chularojmontri L, Herunsalee A (2005) Screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity. Basic Clin Pharmacol Toxicol 96:80–87CrossRefPubMedGoogle Scholar
  120. Willcox DC, Willcox BJ, Todoriki H, Suzuki M (2009) The Okinawan diet: health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load. J Am Coll Nutr 28:S500–S516CrossRefGoogle Scholar
  121. Yang CJ, Wang CS, Hung JY, Huang HW, Chia YC, Wang PH, Weng CF, Huang MS (2009) Pyrogallol induces G2-M arrest in human lung cancer cells and inhibits tumor growth in an animal model. Lung Cancer 66:162–168CrossRefPubMedGoogle Scholar
  122. Yao YB, Peng ZG, Liu ZF, Yang J, Luo J (2010) Effects of mangiferin on cell cycle status and CDC2/cyclin B1 expression of HL-60 cells. Zhong Yao Cai 33:81–85PubMedPubMedCentralGoogle Scholar
  123. Yoshida K, Tanaka T, Hirose Y, Yamaguchi F, Kohno H, Toida M, Hara A, Sugie S, Shibata T, Mori H (2005) Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats. Cancer Lett 221:29–39CrossRefPubMedGoogle Scholar
  124. Yoshimi N, Matsunaga K, Katayama M, Yamada Y, Kuno T, Qiao Z, Hara A, Yamahara J, Mori H (2001) The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats. Cancer Lett 163:163–170CrossRefPubMedGoogle Scholar
  125. Zhang YJ, Nagao T, Tanaka T, Yang CR, Okabe H, Kouno I (2004) Antiproliferative activity of the main constituents from Phyllanthus emblica. Biol Pharm Bull 27:251–255CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Manjeshwar Shrinath Baliga
    • 1
  • Suresh Rao
    • 1
  • Pratima Rao
    • 1
  • Krishnaprasad
    • 1
  • Sanath Kumar Hegde
    • 1
  • Kandel Codi Jalaluddin Akbar
    • 1
  • Soniya Abraham
    • 2
  • Thomas George
    • 2
  • Princy Louis Palatty
    • 2
  1. 1.Mangalore Institute of OncologyMangaloreIndia
  2. 2.Father Muller Medical CollegeMangaloreIndia

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