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Use of Plant Secondary Metabolites as Nutraceuticals for Treatment and Management of Cancer: Approaches and Challenges

  • Zahid H. Siddiqui
  • B. Hareramdas
  • Zahid K. Abbas
  • Talat Parween
  • Mohammad Nasir Khan
Chapter

Abstract

Nowadays cancer has become a common and life-threatening disease, claiming millions of lives and adding many more millions of new cases every year globally. Due to increasing incidences of cancer, a new trend is emerging globally due to accessibility of information on the internet; a lot of cancer patients’ claimed to be “cancer survivor” by use of dietary supplements or nutraceuticals. Nutraceuticals are rich source of nutrients or part of a food that has a medical or health benefit, including the prevention and treatment of diseases. In this chapter, we will discuss the most important nutraceuticals as a source of anticancer agents, such as green tea, chili, pepper, saffron, turmeric, soy, black pepper, fenugreek, cloves, and ginger. These agents are the source of phytomolecules, such as curcumin, crocin, crocetin, capsaicin, diosgenin, isoflavones, resveratrol, epigallocatechin gallate, piperine, eugenol, and gingerol. It has been reported that these phytomolecules are able to prevent, reverse, or delay the carcinogenic process. Over the decades, attention over these nutraceuticals has been increased due to their promising effects on tumor cells. These nutraceuticals exhibit anticancer properties by induction of apoptosis, DNA damage, causing G2/M arrest, inhibition of proliferation, migration and invasion of cancer cells, and sensitizing cancer cells to chemotherapy and radiotherapy. The aim of this chapter is to focus on the sources of nutraceutical compounds and their importance in the management of cancer. Moreover, the mechanism of action is also highlighted.

Keywords

Apoptosis Cancer management Curcumin Nutraceuticals Secondary metabolites 

Notes

Conflict of Interest

The author declares that there is no conflict of interest.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Zahid H. Siddiqui
    • 1
  • B. Hareramdas
    • 2
  • Zahid K. Abbas
    • 1
  • Talat Parween
    • 3
  • Mohammad Nasir Khan
    • 1
  1. 1.Department of Biology, Faculty of ScienceUniversity of TabukTabukKingdom of Saudi Arabia
  2. 2.Department of ZoologyZakir Husain Delhi College, University of DelhiNew DelhiIndia
  3. 3.Division of BioscienceInstitute of Pesticide Formulation TechnologySector 20, Udyog Vihar, NH-8, Gurgaon 122016, HaryanaIndia

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