Piper betle Linn. in Cancer: Past, Present, and Future

  • Avinash Kundadka Kudva
  • Suresh Rao
  • Pratima Rao
  • Romith Periera
  • Ganesh Bhandari
  • Jaffey M. Mathew
  • K. Ashwini
  • Michael L. J. Pais
  • Mallappa Kumara Swamy
  • Manjeshwar Shrinath Baliga


Since time immemorial, Piper betle Linn. (betel vine or paan) has been an integral part of various traditional and folk medicines of Southeast Asian countries. The betel leaves are the most valued plant parts routinely used as chewing agent and known to prevent halitosis. Betel vine leaves possess numerous medicinal benefits, such as relieving indigestion, bronchitis, constipation, congestion, and cough. Betel vine leaves are mostly consumed as a part of betel quid, which consists of areca nut (Areca catechu Linn.), tobacco (Nicotiana tabacum Linn.), and slaked lime, a concoction with potent carcinogenic properties. Routine consumption of betel quid is associated with oral cancer, and scientific analyses have attributed that both tobacco and areca nut as carcinogenic, while slaked lime as a promoter of carcinogenesis. Conversely, betel vine leaves are devoid of carcinogenic effects and in turn known to possess cancer preventive effects that can negate carcinogens present in the quid. The aim of the chapter is to provide the information on betel vine’s cancer preventive effects and the mechanisms involved. Moreover, it also highlighted the various phytoconstituents that promote beneficial role of betel vine leaves against different cancers.


Betel vine Paan Cancer Chemoprevention 


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Avinash Kundadka Kudva
    • 1
  • Suresh Rao
    • 2
  • Pratima Rao
    • 2
  • Romith Periera
    • 2
  • Ganesh Bhandari
    • 2
  • Jaffey M. Mathew
    • 2
  • K. Ashwini
    • 1
  • Michael L. J. Pais
    • 2
  • Mallappa Kumara Swamy
    • 3
  • Manjeshwar Shrinath Baliga
    • 2
  1. 1.Department of BiochemistryMangalore UniversityMangaloreIndia
  2. 2.Mangalore Institute of Oncology, PumpwellMangaloreIndia
  3. 3.Department of Crop Science, Faculty of AgricultureUniversiti Putra MalaysiaSerdangMalaysia

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