Filamentous Bacteriophage Proteins and Assembly
Filamentous bacteriophages, also known as filamentous bacterial viruses or Inoviruses, have been studied extensively over the years. They are interesting paradigms in structural molecular biology and offer insight into molecular assembly, a process that remains to be fully understood. In this chapter, an overview on filamentous bacteriophages will be provided. In particular, we review the constituent proteins of filamentous bacteriophage and discuss assembly by examining the structure of the major coat protein at various stages of the process. The minor coat proteins will also be briefly reviewed. Structural information provides key snapshots into the dynamic process of assembly.
KeywordsInovirus Macromolecular assembly Major coat protein Minor coat proteins
We would like to thank Dr. Walter Scott for carefully reading through the manuscript and providing constructive criticism. We would also like to thank Dr. Don A. Marvin for a wonderful collaboration and for teaching us all we know about filamentous bacteriophage. This chapter is a “lighter” version of our more in-depth review (Marvin et al. 2014), which we invite you to dive into for further details. Finally, funding from the Natural Sciences and Engineering Research Council of Canada is acknowledged.
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