Phytosomes: The Novel Drug Delivery System for Phytomedicine

  • Jubilee Purkayastha
  • Jayita Ghosh


The term “phyto” stands for plant, while “some” means cell like. Phytosome is a technology for producing lipid-compatible molecular complexes of drugs and nutraceuticals, standardized plant extracts or water soluble phytoconsituents so improving their absorption and bioavailability. The novelty of the phytosome process lies in the fact that it produces a little cell, thus protecting the herbal drug from destruction by digestive enzymes and gut bacteria. Because of the presence of water-soluble herbal drug and lipophilic outer layer, phytosomes are easily absorbed and thus become easily bioavailable and provide better actions than the conventional herbal extracts (Jain et al. 2010).


  1. Berger J (2011) The age of biomedicine: current trends in traditional subjects. J Appl Biomed 9:57–61CrossRefGoogle Scholar
  2. Charman WN, Chan HK, Finnin BC, Charman SA (1999) Drug delivery: a key factor in realising the full therapeutic potential of drugs. Drug Dev Res 46:31627CrossRefGoogle Scholar
  3. Devi VK, Nimisha J, Valli KS (2010) Importance of novel drug delivery systems in herbal medicines. Pharmacogn Rev 4(7):27–31CrossRefGoogle Scholar
  4. Dhyani A, Juyal D (2017) Phytosomes: an advanced herbal drug delivery system. Curr Trends Biomedical Eng Biosci 3(5). CTBEB.MS.ID.5555621
  5. Gandhi A, Dutta A, Pal A, Bakshi P (2012) Recent trends of phytosomes for delivering herbal extract with improved bioavailability. J Pharmacogn Phytochem 1(4):6–14Google Scholar
  6. Jain N, Gupta PB, Thakur N, Jain R, Banweer J, Jain DK, Jain S (2010) Phytosome: a novel drug delivery system for herbal medicine. Int J Pharm Sci Drug Res 2(4):224–228Google Scholar
  7. Kumar BA, Habbu P, Lakshman T, Hullatti P, Kumar SR (2017) Phytosomes as novel drug delivery system for herbal medicine –a review. Sys Rev Pharm 8(1):5–7Google Scholar
  8. Maiti K, Mukherjee K, Gantait A, Ahamed HN, Saha BP, Mukherjee PK (2005) Enhanced therapeutic benefit of quercetinphospholipid complex in carbon tetrachloride induced acuteliver injury in rats: a comparative study. Iran J Pharmacol Ther 4:84–90Google Scholar
  9. Musthaba SM, Baboota S, Ahmed S, Ahuja A, Ali J (2009) Status of novel drug delivery technology for phytotherapeutics. Expert Opin Drug Deliv 6:62537CrossRefGoogle Scholar
  10. Norman GB (2001) Herbal drugs and phytopharmaceuticals, A handbook for practice on a scientific basis, 2nd edn. Medpharm Scientific Publishers/CRC Press, Stuttgart/New York, p 23048Google Scholar
  11. Patela J, Patelb R, Khambholjab K, Patela N (2009) An overview of phytosomes as an advanced herbal drug delivery system. An Overview Phytosomes/Asian J Pharm Sci 4(6):363–371Google Scholar
  12. Semalty A, Semalty M, Rawat BS, Singh D, Rawat MS (2009) Pharmacosomes: the lipidbased new drug delivery system. Expert Opin Drug Deliv 6:599612CrossRefGoogle Scholar
  13. Shelke SS (2012) Phytosomes – a new herbal drug delivery system. Int J Pharm Biomed Sci 3(4):1709–1715Google Scholar
  14. Suryawanshi JAS (2011) Phytosome: an emerging trend in herbal drug treatment. J Med Genet Genomics 3(6):109–114Google Scholar
  15. Tedesco D, Steidler S, Galletti S, Tameni M, Sonzogni O, Ravarotto L (2004) Efficacy of silymarin–phospholipid complex in reducing the toxicity ofaflatoxin B1 in broiler chicks. Poult Sci 83:1839–1843CrossRefGoogle Scholar
  16. Yanyu X, Yunmei S, Zhipeng C, Quineng P (2006) The Q preparation of Silybinphospholipidcomplex and the study on its pharmacokinetics in rats. Int J Pharm 307:77–82CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Jubilee Purkayastha
    • 1
  • Jayita Ghosh
    • 2
  1. 1.Institute of Nuclear Medicine and Allied Sciences (INMAS)Defence Research and Development Organisation (DRDO)DelhiIndia
  2. 2.Amity Institute of Biotechnology (AIB)Amity University Uttar Pradesh (AUUP)NoidaIndia

Personalised recommendations