Platelet-Derived Growth Factor Receptor (PDGF-R) as the Target for Herbal-Based Anticancer Agents

  • Manjula Devi Ramamoorthy
  • Kannan Narayanan DhiraviamEmail author


In the preceding few years, there has been an exponential development in the field of herbal medicine against cancers due to their natural origin and relatively less adverse reactions than chemotherapy. For quite some time, plant-based molecules have been a source of therapeutic agents, and they keep on playing a crucial part as new investigational drugs against different illnesses including malignancy. The herbal products interact with a wide assortment of proteins, for example, catalysts, transcription factors, inflammatory cytokines, and gene products, correlated with cancer cell survival, invasion, proliferation, migration, and angiogenesis. Most fatal illnesses are caused by alterations of nearly 500 unique genes. The vast group of protein tyrosine kinase functions as a component of signaling pathways and tends to be fundamental for the transforming activity of normal cells into cancerous cells. In which, platelet-derived growth factor receptor (PDGF-R) has a prominent part in the initiation of cell signaling pathways. Platelet-derived growth factor (PDGF) isoforms and their receptors play a vital role in the direction of development and survival of cancer cells. In diseased condition, upgraded motioning of this receptor is the trademark. In particular cases, the persistence of PDGF signaling is fundamental to the survival of malignant cells. Thus, hindrance of PDGF receptor signaling has turned out to be valuable for curing patients with certain rare tumors. The advancement of receptor tyrosine kinase inhibitors that can obstruct diseases caused by abnormalities in this signaling pathway is considered as a promising methodology for the drug development. These drug revelation endeavors have created inhibitors and low molecular weight therapeutics coordinated against the ATP-restricting locales of protein kinases. The aim of this chapter is to discuss the production of plant secondary metabolites that might block tumor metastasis by targeting PDGF-R phosphorylation.


Metastasis Angiogenesis Plant secondary metabolites Platelet-derived growth factor Receptor Tyrosine kinases 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Manjula Devi Ramamoorthy
    • 1
  • Kannan Narayanan Dhiraviam
    • 1
    Email author
  1. 1.Department of Plant Biotechnology, School of BiotechnologyMadurai Kamaraj UniversityMaduraiIndia

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