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Therapeutic Strategies of Natural Agents on Triple-Negative Breast Cancer

  • Ashok Kumar Pandurangan
  • Mohd Rais Mustafa
Chapter

Abstract

Triple-negative breast cancers (TNBC) are described as a human breast cancer subtype that does not express estrogen receptor (ER) and progesterone receptor (PR), and they lack overexpression and/or lack gene amplification of human epidermal growth factor receptor 2 (HER2). TNBC are highly aggressive, and they are present among 10–15% of all breast cancer subtypes which constitute about 80% of all basal-like tumours. Plants produce diverse number of organic compounds. Traditionally these natural products are known as secondary metabolites or phytometabolites. Bioactive natural products’ chemical structure and function have been studied since the 1850s. Comprehending these chemical structure and functions led to recognition of their biological properties as anticancer drugs. Among phytometabolites, phytoestrogens have been widely studied as a chemopreventive and chemotherapeutic agent due to their high affinity to interact with estrogen receptors. However, TNBC are indifferent to hormonal therapy, they became a therapeutic hurdle. The only systemic therapy currently left is chemotherapy which often fails due to ability of TNBC to develop resistance to chemotherapeutic drugs. Therefore, different theories exist, which suggest focusing on drugs that target TNBC survival-dependent molecular pathways instead. For instance, several studies reported TNBC depend on NF-κB to survive and avoid apoptosis. The aim of this chapter is to discuss the various bioactive natural products extracted from various parts of plants and mushrooms showing potential inhibitory effect against TNBC.

Keywords

Chemotherapy Hormonal receptors Natural products Molecular pathway Triple-negative breast cancer 

Notes

Acknowledgement

We are thankful to Dr. Yamini Chandramohan, Centre for Biotechnology, Anna University, Chennai, India, for her critical comments to improve the quality of the manuscript.

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.School of Life SciencesB. S. Abdur Rahman Crescent Institute of Science and TechnologyChennaiIndia
  2. 2.Faculty of Medicine, Centre for Natural Products and Drug Discovery (CENAR)University of MalayaKuala LumpurMalaysia

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