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Tumors of the Skin

  • Yong-Hang Zhu
  • Gui-Xiu Zhang
  • Li Tang
  • Xiao-Jie Li
  • Wen-Yuan Zhu
  • Ru-Zhi Zhang
  • Ming-Yu Xia
  • Lei Wang
  • Ying Ren
  • Hui-Pu Zhou
  • De-Hai Pan
  • Li-Jian Xiang
  • Jin-Fa Su
  • Hui Zhang
  • Juan Du
  • Mai-Hua Hou
  • Dong-Lai Ma
  • Shu-Qin Lv
  • Xi-Chuan Yang
  • Jie Gao
  • Ting Lin
  • Shao-Wen Peng
  • Zhi-Ping Sun
  • Li Yang
  • Cheng Tan
  • Ji-Ling Zhang
  • Yan Wu
  • Hong Zhang
  • Gang Liu
  • Bao-Chun Li
  • Shun-Fan Li
  • Lan Yang
  • Jie Yan
  • Yang Guan
  • Yin Xiao
  • Yan Yan
  • Zhi-Fang Zhai
  • Shan Tang
  • Zhong Xie
  • Feng Wu
  • Xiao-Mei Zhang
  • Jian-Fang Sun
  • Wen-Hai Li
  • Mei Cai
  • Chun-Mei Zhang
  • Xian Zhang
  • Gang Wang
  • Hong-Hao Jiang
  • Jiang Jin
  • Xiong-Ming Pu
  • Jian-Min Chang
  • Yan Lu
  • Xiao-Jun Zhu
  • Cun-Cai Zhou
  • Shu-Fang Qiao
  • Jian-Ping Liang
  • Zhi-Xin Song
  • Yi-Ming Xu
  • Jun Peng
  • Hong-Zhong Jin
  • Chun-Xing Xu
  • Jing Fang
  • Chuan-Ping Xing
  • Xiao-Bing Pi
  • Dian-Ying Zhuang
  • Jia-Bi Wang
  • Jian-Ying Zeng
  • Min Huang
  • Chun-Yang Li
  • Bing-Nan Cui
  • Xiao-Yan Guo
  • Tong Lin
  • Bing-Sen Qiu
  • Bin Su
  • Xue-Jun Zhu
  • Pei-Hua Song
  • Guang-Cai Xiang
  • Guang-Ren Liu
  • Sheng-Shun Tan
  • Yi-Qun Jiang
  • Min Zheng
  • Jin Hu
  • Guang-He Yang
  • Zheng Ge
  • Jing Chen
  • Lin Cai
  • Sheng Wang
  • An Liu
  • Xian Jiang
Chapter

Abstract

Skin tumor is the most intriguing topic for the clinicians. This chapter covers a wide range of issues and provides with informative clues and tips associated with clinical features and pathological presentations and keeps pace with the latest development in molecular biology and immunohistochemistry to assist the readers in the establishment of accurate diagnosis. These following disorders are elaborately selected and arranged from a histopathological perspective.

(1) Tumors of the epidermis include epidermal nevus, unilateral epidermal nevus, epidermal nevus syndrome, seborrheic keratosis, seborrheic keratosis and pityrosporum ovale, large cell acanthoma, giant cutaneous horn, multiple Bowen’s disease, extramammary Paget’s disease, eruptive keratoacanthoma, superficial basal cell carcinoma, fibroepithelioma of Pinkus, Marjolin’s ulcer of squamous cell carcinoma secondary to radiation, cutaneous clear cell squamous cell carcinoma, and milia en plaque.

(2) The list of cutaneous appendage proliferations and tumors present cases with eruptive vellus hair cysts, nevus comedonicus, dilated pore, inverted follicular keratosis, infundibulocystic basal cell carcinoma, trichofolliculoma, trichoepithelioma, bullous pilomatricoma, areolar sebaceous hyperplasia, nevus sebaceous with apocrine cystadenoma, linear nevus sebaceous syndrome, apocrine hidrocystoma, eccrine angiomatous hamartoma, syringocystadenoma papilliferum, eruptive milium-like syringoma, segmental multiple eccrine spiradenomas, clear cell hidradenoma, malignant eccrine poroma, or microcystic adnexal carcinoma.

(3) The category of cutaneous soft tissue proliferations and neoplasms introduces acquired digital fibrokeratoma, epithelioid cell histiocytoma, multiple eruptive dermatofibromas, intradermal nodular fasciitis, dermatofibrosarcoma protuberan, epithelioid sarcoma, superficial angiomyxoma, multicentric reticulohistiocytosis, Letterer-Siwe disease, cutaneous Rosai-Dorfman disease, phakomatosis pigmentovascularis, angiokeratoma corporis diffusum, angiokeratoma of Fordyce, angioma serpiginosum, reactive angioendotheliomatosis, epithelioid hemangioma, tufted angioma, verrucous hemangioma, targetoid hemosiderotic hemangioma, microvenular hemangioma, glomus tumor, spindle cell hemangioma, Kaposiform hemangioendothelioma, classic Kaposi’s sarcoma, cutaneous angiosarcoma, acquired progressive lymphangioma, lymphangioma, nevus lipomatosus superficialis, encephalocraniocutaneous lipomatosis, madelung disease, multiple leiomyoma, cutaneous leiomyosarcoma, subungual exostosis, and cutaneous endometriosis.

(4) Palisaded encapsulated neuroma, schwannoma, and cutaneous Merkel cell carcinoma belong to neural tumors.

(5) Melanocytic nevi and neoplasms include agminated Spitz nevus, subungual melanoma, fatal leptomeningeal melanoma in neurocutaneous melanosis, as well as rare forms of cutaneous melanoma.

(6) Cutaneous lymphoid proliferations and leukemic infiltration consist of cutaneous pseudolymphoma, Jessner’s lymphocytic infiltration of the skin Jessner, Ketron-Goodman disease, mycosis fungoides, erythrodermic cutaneous T-cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma, hydroa vacciniforme-like lymphoma, extranodal NK-/T-cell lymphoma, primary cutaneous B-cell lymphoma, maculopapular cutaneous mastocytosis, diffuse cutaneous mastocytosis, mastocytoma, cutaneous plasmacytoma, polycythemia vera, leukemia cutis, and so on.

(7) Cutaneous metastases include cutaneous metastasis for lung cancer, cutaneous metastasis of gastrointestinal malignancy, Sister Mary Joseph’s nodule, and carcinoma en cuirasse.

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Copyright information

© Springer Nature Singapore Pte Ltd. and People's Military Medical Press 2018

Authors and Affiliations

  • Yong-Hang Zhu
    • 1
  • Gui-Xiu Zhang
    • 2
  • Li Tang
    • 3
  • Xiao-Jie Li
    • 4
  • Wen-Yuan Zhu
    • 4
  • Ru-Zhi Zhang
    • 5
  • Ming-Yu Xia
    • 6
  • Lei Wang
    • 7
  • Ying Ren
    • 8
  • Hui-Pu Zhou
    • 9
  • De-Hai Pan
    • 10
  • Li-Jian Xiang
    • 11
  • Jin-Fa Su
    • 12
  • Hui Zhang
    • 13
  • Juan Du
    • 14
  • Mai-Hua Hou
    • 4
  • Dong-Lai Ma
    • 15
  • Shu-Qin Lv
    • 16
  • Xi-Chuan Yang
    • 17
  • Jie Gao
    • 18
  • Ting Lin
    • 19
  • Shao-Wen Peng
    • 17
  • Zhi-Ping Sun
    • 20
  • Li Yang
    • 21
  • Cheng Tan
    • 22
  • Ji-Ling Zhang
    • 23
  • Yan Wu
    • 24
  • Hong Zhang
    • 25
  • Gang Liu
    • 26
  • Bao-Chun Li
    • 27
  • Shun-Fan Li
    • 28
  • Lan Yang
    • 15
  • Jie Yan
    • 15
  • Yang Guan
    • 29
  • Yin Xiao
    • 30
  • Yan Yan
    • 15
  • Zhi-Fang Zhai
    • 17
  • Shan Tang
    • 31
  • Zhong Xie
    • 32
  • Feng Wu
    • 33
  • Xiao-Mei Zhang
    • 34
  • Jian-Fang Sun
    • 35
  • Wen-Hai Li
    • 36
  • Mei Cai
    • 37
  • Chun-Mei Zhang
    • 38
  • Xian Zhang
    • 39
  • Gang Wang
    • 7
  • Hong-Hao Jiang
    • 33
  • Jiang Jin
    • 14
  • Xiong-Ming Pu
    • 40
  • Jian-Min Chang
    • 36
  • Yan Lu
    • 4
  • Xiao-Jun Zhu
    • 41
  • Cun-Cai Zhou
    • 42
  • Shu-Fang Qiao
    • 29
  • Jian-Ping Liang
    • 43
  • Zhi-Xin Song
    • 44
  • Yi-Ming Xu
    • 40
  • Jun Peng
    • 45
  • Hong-Zhong Jin
    • 15
  • Chun-Xing Xu
    • 46
  • Jing Fang
    • 4
  • Chuan-Ping Xing
    • 47
  • Xiao-Bing Pi
    • 14
  • Dian-Ying Zhuang
    • 48
  • Jia-Bi Wang
    • 15
  • Jian-Ying Zeng
    • 15
  • Min Huang
    • 49
  • Chun-Yang Li
    • 50
  • Bing-Nan Cui
    • 51
  • Xiao-Yan Guo
    • 52
  • Tong Lin
    • 53
  • Bing-Sen Qiu
    • 54
  • Bin Su
    • 15
  • Xue-Jun Zhu
    • 32
  • Pei-Hua Song
    • 10
  • Guang-Cai Xiang
    • 10
  • Guang-Ren Liu
    • 14
  • Sheng-Shun Tan
    • 55
  • Yi-Qun Jiang
    • 56
  • Min Zheng
    • 57
  • Jin Hu
    • 58
  • Guang-He Yang
    • 59
  • Zheng Ge
    • 60
  • Jing Chen
    • 61
  • Lin Cai
    • 62
  • Sheng Wang
    • 63
  • An Liu
    • 59
  • Xian Jiang
    • 64
  1. 1.Department of DermatologyLiaoning General Hospital of Nuclear IndustryXingchengChina
  2. 2.Department of DermatologyThe First People’s Hospital of YunnanKunmingChina
  3. 3.Department of DermatologyTianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjinChina
  4. 4.Department of DermatologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingChina
  5. 5.Department of DermatologyThe Third Affiliated Hospital of Suzhou UniversityChangzhouChina
  6. 6.Nanjing Medical UniversityNanjingChina
  7. 7.Institute of Dermatology of Chinese PLA, Xijing HospitalThe Fourth Military Medical UniversityXi’anChina
  8. 8.Department of DermatologyAffiliated Hospital of Chengde Medical CollegeChengdeChina
  9. 9.Department of DermatologyThe People’s Hospital of ShanweiShanweiChina
  10. 10.Department of DermatologyChina-Japan Friendship HospitalBeijingChina
  11. 11.Department of DermatologyThe First Hospital of HangzhouHangzhouChina
  12. 12.Department of DermatologySkin Disease Prevention CenterJingmenChina
  13. 13.Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina
  14. 14.Department of DermatologyPeking University People’s HospitalBeijingChina
  15. 15.Department of Dermatology, Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  16. 16.Department of DermatologyFujian Dongshan County HospitalFujianChina
  17. 17.Department of Dermatology and Venereology, Southwest HospitalThird Military Medical UniversityChongqingChina
  18. 18.Department of Dermatology and VenereologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingChina
  19. 19.Department of DermatologyGeneral Hospital of Guangzhou Military Command of PLAGuangzhouChina
  20. 20.Department of DermatologyDongguan Donghua HospitalGuangzhouChina
  21. 21.Department of Dermatology, Xijing Hospital, Institute of PLA DermatologyThe Fourth Military Medical UniversityXi’anChina
  22. 22.Department of DermatologyAffiliated Hospital of Nanjing University of Chinese MedicineNanjingChina
  23. 23.Department of DermatologyThe Affiliated Hospital of Zunyi Medical CollegeZunyiChina
  24. 24.Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  25. 25.Department of DermatologyAir Force General Hospital, PLABeijingChina
  26. 26.Department of Plastic SurgeryTianjin Changzheng HospitalTianjinChina
  27. 27.Department of DermatologyXian Yang Central HospitalXian YangChina
  28. 28.Department of DermatologyAffiliated Hospital of Guangzhou Medical UniversityGuangzhouChina
  29. 29.Department of DermatologyTianjin Changzheng HospitalTianjinChina
  30. 30.Department of PathologyTianjin Changzheng HospitalTianjinChina
  31. 31.Institute of Dermatology and STD of Fujian ProvinceFuzhouChina
  32. 32.Department of DermatologyPeking University First HospitalBeijingChina
  33. 33.Department of Dermatology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  34. 34.Panyu Chronic Disease HospitalGuangzhouChina
  35. 35.Institute of DermatologyChinese Academy of Medical SciencesNanjingChina
  36. 36.Department of DermatologyBeijing HospitalBeijingChina
  37. 37.Department of Dermatology, The Second Affiliated HospitalKunming Medical CollegeKunmingChina
  38. 38.Department of Dermatology, The Second HospitalShandong UniversityJinanChina
  39. 39.Department of Dermatology, Nantong Rich HospitalFourth Clinical College of Yangzhou UniversityNantongChina
  40. 40.Department of DermatologyThe People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiChina
  41. 41.Department of DermatologySecond Affiliated Hospital of Sun Yat-Sen UniversityGuangZhouChina
  42. 42.Department of Medical Cosmetology, Heping HospitalThe Changzhi Medical CollegeChangzhiChina
  43. 43.Department of DermatologyDatong Fifth HospitalDatongChina
  44. 44.Department of SurgeryQianan People’s HospitalQiananChina
  45. 45.Department of DermatologyCangzhou People’s HospitalCangzhouChina
  46. 46.Department of DermatologyThe Third Affiliated Hospital of Souzhou UniversityChangzhouChina
  47. 47.Department of PathologyLanzhou General Hospital of Lanzhou Military CommandLanzhouChina
  48. 48.Department of DermatologyChaoyang Dafeng Hospital of ShantouShantouChina
  49. 49.Department of DermatologyShenzhen Center for Chronic Disease ControlShenzhenChina
  50. 50.Department of Dermatology, Qilu HospitalShandong UniversityJinanChina
  51. 51.Department of Dermatology, Guang’anmen HospitalChina Academy of Traditional Chinese MedicineBeijingChina
  52. 52.Department of DermatologyTangshan Union HospitalTangshanChina
  53. 53.Department of Dermatology, Institute of Dermatology and Hospital for Skin DiseasesChinese Academy of Medical Sciences & Peking Union Medical CollageNanjingChina
  54. 54.Department of DermatologyHuashan Hospital of Fudan UniversityShanghaiChina
  55. 55.Department of DermatologySecond Hospital of Xi’an Jiaotong UniversityXi’anChina
  56. 56.Institute of Dermatology, Peking Union Medical CollegeChinese Academy of Medical ScienceNanjingChina
  57. 57.Department of DermatologyThe Second Affiliated Hospital of Zhejiang Medical UniversityHangzhouChina
  58. 58.Department of DermatologyAffiliated Hospital of Children Capital Institute of PediatricsBeijingChina
  59. 59.Department of DermatologyHubei Jianghan Oilfield Central HospitalQianjiangChina
  60. 60.Department of HematologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingChina
  61. 61.Department of DermatologyTianjin Gong’an HospitalTianjinChina
  62. 62.Department of DermatologyPeople’s Hospital of Beijing UniversityBeijingChina
  63. 63.Department of Dermatology, West China HospitalSichuan UniversityChengduChina
  64. 64.Department of Dermatology and VenereologyWest China Hospital of Sichuan UniversityChengduChina

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