Advertisement

Methanol Intoxication with Bilateral Acute Visual Loss

  • An-Guor Wang
Chapter

Abstract

An 86-year-old male visited our emergency room because of a sudden visual loss in both eyes noted that morning. He had been drinking alcoholic beverages with his friends 2 days prior to admission. According to the patient, there were four different brands of alcoholic beverages consumed—one bought at the grocery store and three provided by friends. The patient noticed bilateral visual loss upon awakening and was brought to the emergency room by his family. He reported a past medical history of hypertension, diabetes mellitus, and coronary artery disease with congestive heart failure.

References

  1. 1.
    Barceloux DG, Bond GR, Krenzelok EP, Cooper H, Vale JA. American Academy of Clinical Toxicology Practice Guidelines on the treatment of methanol poisoning. J Toxicol Clin Toxicol. 2002;40:415–46.CrossRefPubMedGoogle Scholar
  2. 2.
    Hantson P, Duprez T, Mahieu P. Neurotoxicity to the basal ganglia shown by magnetic resonance imaging (MRI) following poisoning by methanol and other substances. J Toxicol Clin Toxicol. 1997;35:151–61.CrossRefPubMedGoogle Scholar
  3. 3.
    Keyhani J, Keyhani E. EPR study of the effect of formate on cytochrome C oxidase. Biochem Biophys Res Commun. 1980;92:327–33.CrossRefPubMedGoogle Scholar
  4. 4.
    Seme MT, Summerfelt P, Neitz J, Eells JT, Henry MM. Differential recovery of retinal function after mitochondrial inhibition by methanol intoxication. Invest Ophthalmol Vis Sci. 2001;42:834–41.PubMedGoogle Scholar
  5. 5.
    Benton CD Jr, Calhoun FP Jr. The ocular effects of methyl alcohol poisoning. Report of a catastrophe involving 320 persons. Am J Ophthalmol. 1952;36:1677–85.CrossRefGoogle Scholar
  6. 6.
    Hayreh MS, Hayreh SS, Baumbach GL, Cancilla P, Martin-Amat G, Tephly TR, et al. Methyl alcohol poisoning III. Ocular toxicology. Arch Ophthalmol. 1977;95:1851–8.CrossRefPubMedGoogle Scholar
  7. 7.
    Sharpe JA, Hostovsky M, Bilbao JM, Rewcastle NB. Methanol optic neuropathy: a histopathological study. Neurology. 1982;32:1093–100.CrossRefPubMedGoogle Scholar
  8. 8.
    Gaul HP, Wallace CJ, Auer RN, Fong TC. MR findings in methanol intoxication. AJNR Am J Neuroradiol. 1995;16:1783–6.PubMedGoogle Scholar
  9. 9.
    Rubinstein D, Escott E, Kelly JP. Methanol intoxication with putaminal and white matter necrosis: MR and CT findings. AJNR Am J Neuroradiol. 1995;16:1492–4.PubMedGoogle Scholar
  10. 10.
    McLean DR, Jacobs H, Mielke BW. Methanol poisoning: a clinical and pathological study. Ann Neurol. 1980;8:161–7.CrossRefPubMedGoogle Scholar
  11. 11.
    Hsieh FY, Leu TM, Chia LG. Bilateral putaminal necrosis caused by methanol poisoning: a case report. Zhonghua Yi Xue Za Zhi (Taipei). 1992;49:283–8.Google Scholar
  12. 12.
    Kuteifan K, Oesterle H, Tajahmady T, Gutbub AM, Laplatte G. Necrosis and hemorrhage of the putamen in methanol poisoning shown on MRI. Neuroradiology. 1998;40:158–60.CrossRefPubMedGoogle Scholar
  13. 13.
    Anderson CA, Rubinstein D, Filley CM, Stears JC. MR enhancing brain lesions in methanol intoxication. J Comput Assist Tomogr. 1997;21:834–6.CrossRefPubMedGoogle Scholar
  14. 14.
    Blanco M, Casado R, Vazquez F, Pumar JM. CT and MR imaging findings in methanol intoxication. AJNR Am J Neuroradiol. 2006;27:452–4.PubMedPubMedCentralGoogle Scholar
  15. 15.
    Hsu HH, Chen CY, Chen FH, Lee CC, Chou TY, Zimmerman RA. Optic atrophy and cerebral infarcts caused by methanol intoxication: MRI. Neuroradiology. 1997;39:192–4.CrossRefPubMedGoogle Scholar
  16. 16.
    Deniz S, Oppenheim C, Lehericy S, Sharshar T, Lalam TF, Dormont D, et al. Diffusion-weighted magnetic resonance imaging in a case of methanol intoxication. Neurotoxicology. 2000;21:405–8.PubMedGoogle Scholar
  17. 17.
    Arora V, Nijjar IB, Multani AS, Singh JP, Abrol R, Chopra R, et al. MRI findings in methanol intoxication: a report of two cases. Br J Radiol. 2007;80:e243–6.CrossRefPubMedGoogle Scholar
  18. 18.
    Ahsan H, Akbar M, Hameed A. Diffusion weighted image (DWI) findings in methanol intoxication. J Pak Med Assoc. 2009;59:322–3.Google Scholar
  19. 19.
    Onder F, Ilker S, Kansu T, Tatar T, Kural G. Acute blindness and putaminal necrosis in methanol intoxication. Int Ophthalmol. 1999;22:81–4.CrossRefGoogle Scholar
  20. 20.
    Server A, Hovda KE, Nakstad PH, Jacobsen D, Dullerud R, Haakonsen M. Conventional and diffusion-weighted MRI in the evaluation of methanol poisoning: a case report. Acta Radiol. 2003;44:691–5.PubMedGoogle Scholar
  21. 21.
    Koopmans RA, Li DKB, Paty DW. Basal ganglia lesions in methanol poisoning: MR appearance. J Comput Assist Tomogr. 1988;12:168–9.CrossRefPubMedGoogle Scholar
  22. 22.
    Kruse JA. Methanol and ethylene glycol intoxication. Crit Care Clin. 2012;28(4):661–711.  https://doi.org/10.1016/j.ccc.2012.07.002.CrossRefPubMedGoogle Scholar
  23. 23.
    Rietjens SJ, de Lange DW, Meulenbelt J. Ethylene glycol or methanol intoxication: which antidote should be used, fomepizole or ethanol? Neth J Med. 2014;72(2):73–9.PubMedGoogle Scholar
  24. 24.
    Tephly TR. The toxicity of methanol. Life Sci. 1991;48:1031–41.CrossRefPubMedGoogle Scholar
  25. 25.
    Brent J, McMartin K, Phillips S, Aaron C, Kulig K. Fomepizole for the treatment of methanol poisoning. N Engl J Med. 2001;344:424–9.CrossRefPubMedGoogle Scholar
  26. 26.
    Swartz RD, Millman RP, Billi JE, Bondar NP, Migdal SD, Simonian SK, et al. Epidemic methanol poisoning: clinical and biochemical analysis of a recent episode. Medicine (Baltimore). 1981;60:373–82.CrossRefGoogle Scholar
  27. 27.
    Naraqi S, Dethlefs RF, Slobodniuk RA, Sairere JS. An outbreak of acute methyl alcohol intoxication. Aust NZ J Med. 1979;9:65–8.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • An-Guor Wang
    • 1
  1. 1.Department of OphthalmologyTaipei Veterans General Hospital, National Yang-Ming University School of Medicine, Yun-San Ophthalmology Education Research FoundationTaipeiTaiwan

Personalised recommendations