Epigenetic Patterns/Therapies Associated with Genetic Disorders

  • Elizabeth Mazzio
  • Karam F. A. SolimanEmail author


Within the past three centuries, all-cause disease burden in developed countries has shifted from infectious to non-communicable (NCD)/genetic based diseases including cardiovascular conditions, cancer, neuropsychiatric conditions, and diabetes. Factors accounting for this drift include discoveries in vaccination (e.g., tetanus, cholera, typhoid, plague, anthrax, and tuberculosis), antibiotics, advances in medical diagnostics, lasers, surgical techniques, and routine medicines to treat almost every type of systemic imbalance. Moreover, advances in public health, sanitation, food safety, and geriatric sciences are creating extended life expectancy, where age-related illnesses (osteoarthritis, back pain, neurodegenerative conditions) in addition to NCDs are plaguing an ever-growing elderly population. The age-related risk for these diseases is now worsened by aggregation of global industrial pollutants, where the World Health Organization (WHO) now uses the term “environmental burden of disease” to describe adverse effects of a man-made climate, ecosystem degradation, cumulative rise in pollutants, noise, and electromagnetic fields, etc. While epigenetic environmental triggers can alter disease risk, the epigenome contains a plethora of drug targets which can alter the expression of pathological gene traits.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.College of Pharmacy and Pharmaceutical SciencesFlorida A&M UniversityTallahasseeUSA
  2. 2.Center of Excellence for Cancer Research, Training and Community Service, College of Pharmacy and Pharmaceutical SciencesFlorida A&M UniversityTallahasseeUSA

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