α-Amylase Inhibitor’s Performance in the Control of Diabetes Mellitus: An Application of Computational Biology

  • Jyoti Verma
  • C. Awasthi
  • Qazi Mohammad Sajid Jamal
  • Mohd. Haris Siddiqui
  • Gulshan Wadhwa
  • Kavindra Kumar KesariEmail author


Diabetes mellitus is the most widespread disorders prevalent in current period. α-Amylase enzyme plays a key role in the onset of the abnormal condition by breaking starch into glucose; hence its inhibitors need to be studied thoroughly. Due to the various side effects posed by the existing commercial non-proteinaceous inhibitors, exploration of the natural plant-based inhibitors of the enzyme is the present-day demand. Ample of plants have been extensively studied and reported to exhibit hypoglycaemic properties. This article describes the mode of action of amylase enzyme, phytochemicals which behave as amylase inhibitors and classes of its inhibitors and summarizes various plants studied for their enzyme inhibitory properties including computational tools and techniques to analyse the binding pattern exploration of inhibitors using molecular interaction with enzymes of interest.


Diabetes mellitus α-Amylase inhibitors Phytochemicals 



This study was supported by TEQIP-II (Technical Education Quality Improvement Programme, Government of India).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Jyoti Verma
    • 1
  • C. Awasthi
    • 1
  • Qazi Mohammad Sajid Jamal
    • 2
  • Mohd. Haris Siddiqui
    • 3
  • Gulshan Wadhwa
    • 4
  • Kavindra Kumar Kesari
    • 5
    Email author
  1. 1.Department of BiotechnologyGobind Ballabh Pant Engineering CollegePauri GarhwalIndia
  2. 2.Department of Health Information ManagementCollege of Applied Medical Sciences, East Qassim UniversityAl Qassim-BuraydahKingdom of Saudi Arabia
  3. 3.Department of Bioengineering, Faculty of EngineeringIntegral UniversityLucknowIndia
  4. 4.Department of Biotechnology, Apex Bioinformatics CentreMinistry of Science & TechnologyNew DelhiIndia
  5. 5.Department of Applied Physics, and Department of Bioproduct & BiosystemAalto UniversityEspooFinland

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