Role of Bioinformatics in Drug Resistance Prediction for HIV/AIDS
The successful treatment of human immunodeficiency virus (HIV) infection is majorly affected by development of viral drug resistance. This complicates physician to choose the right choice of drugs. In such a scenario, a series of bioinformatics software tools and databases have been developed for predicting drug resistance, and responses to combination therapy from viral genotype have been developed to support physician. In this paper, we provided an up-to-date review on current treatment options, exploring the potential of novel targets and developed computational tools and databases for current HIV therapy in viral drug resistance.
KeywordsCombination therapy Drug resistance HAART HIV databases Genotypic resistance testing Phenotypic resistance testing
J.M. is supported by BTIS scheme of Department of Biotechnology (DBT), Government of India, New Delhi, India.