Histopathology of Uterine Leiomyoma

  • Yoshiki MikamiEmail author
Part of the Comprehensive Gynecology and Obstetrics book series (CGO)


Uterine leiomyoma shows a wide spectrum of morphologies and clinicopathological features. Thus, in both the clinical and pathological settings, it can be difficult to distinguish from leiomyosarcoma. In particular, patients scheduled for conservative laparoscopic procedures need careful preoperative evaluation, because in rare cases microscopic examination may instead reveal leiomyosarcoma. Clinicians should therefore be familiar with the variety of manifestations and imaging characteristics of both leiomyoma and leiomyosarcoma. In this chapter, the morphologic features and current diagnostic criteria for leiomyoma, as opposed to leiomyosarcoma, and the controversies regarding the diagnosis of borderline tumors are presented. The focus includes smooth muscle tumors of uncertain malignant potential.


Uterus Fibroid Leiomyoma Pathology Variants 


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Diagnostic PathologyKumamoto University HospitalKumamotoJapan

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