LHRH Agonist and Antagonist for Prostate Cancer

  • Jin Bong Choi
  • Jun Sung KohEmail author


ADT is the main treatment for advanced prostate cancer. Combination therapy with radiotherapy in early stage prostate cancer is increasing. LHRH agonists are the most frequently used type of ADT for several years, and they have suppressed the serum testosterone to castration level in almost all patients. Furthermore, LHRH antagonist was developed recently as an alternative form of ADT with direct and immediate suppression of testosterone without initial testosterone flare phenomenon. Therefore, in this chapter, we will describe the comparative efficacy and safety between LHRH agonists and LHRH antagonists for prostate cancer.


Prostate cancer Androgen deprivation therapy Gonadotropin-releasing hormone Testosterone Prostate-specific antigen 


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of UrologyCollege of Medicine, The Catholic University of KoreaSeoulSouth Korea

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