E2F1: Transcriptional Machinery in Colon Cancer
E2F family of transcription factor acts as central modulator for important cellular events including cell cycle progression, apoptosis, and DNA damage response. E2F1 regulates G1/S-phase transition of cell cycle transactivating a variety of genes involved in chromosomal DNA replication, including its own promoter. E2F1 is regulated in a cell cycle-dependent manner, principally through its temporal association with pocket protein family member, retinoblastoma. Pocket proteins, in turn, regulated through phosphorylation by cyclin-dependent kinase (CDK). Different E2F family exhibits distinct cell cycle and apoptotic activities. This review focuses on E2F1 function and its putative role in colon cancer.
KeywordsE2F1 Colon cancer Retinoblastoma (RB) CDK
- 2.Banerjee, D., Gorlick, R., Liefshitz, A., Danenberg, K., Danenberg, P. C., Danenberg, P. V., ... Kemeny, N. (2000). Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase. Cancer Res 60(9):2365–2367Google Scholar
- 9.Engelmann, D., Mayoli-Nüssle, D., Mayrhofer, C., Fürst, K., Alla, V., Stoll, A., ... Pützer, B. M. (2013). E2F1 promotes angiogenesis through the VEGF-C/VEGFR-3 axis in a feedback loop for cooperative induction of PDGF-B. J Mol Cell Biol, mjt035Google Scholar
- 20.Zhang, E., Yin, D., Han, L., He, X., Si, X., Chen, W., ... Guo, R. (2016). E2F1-induced up regulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs. Oncotarget 7(17):23212Google Scholar