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Activator Protein-1 Transcription Factors in Pathological Cancers

  • Siva Krishna Prasad Konduru
  • Ganji Lakshmi Vara Prasad
  • Neha Merchant
  • Santoshi Muppala
Chapter

Abstract

Activator protein-1 transcription factors play a critical role in the development of many cancers. Although many studies indicated the role of transcription factors driving the progression of cancer, there is still a knowledge gap in the process of better understanding the molecular mechanisms controlled by AP-1 transcription factors during cancer advancement. In conclusion, we have evaluated the role of transcription factors which provides new insights into mechanisms of regulation of colorectal cancer by AP-1 family transcription factors.

Keywords

AP-1 transcription factors Colorectal cancer Metastasis Oncogenes 

Abbreviations

%

Percent

AP-1

Activator protein-1

ATF

Activating transcription factor

CRC

Colorectal cancer

MAF

Musculoaponeurotic liposarcoma

TPA

12-O-tetradecanoylphorbol-13-acetate

TRE

TPA-response element

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Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  • Siva Krishna Prasad Konduru
    • 1
  • Ganji Lakshmi Vara Prasad
    • 2
  • Neha Merchant
    • 3
  • Santoshi Muppala
    • 4
  1. 1.Department of Medical ImagingSangre Grande General HospitalSangre GrandeTrinidad and Tobago
  2. 2.Dr. LV Prasad Diagnostics and Research LaboratoryHyderabadIndia
  3. 3.Department of Hematology and Medical Oncology, Winship Cancer InstituteEmory UniversityAtlantaUSA
  4. 4.Department of Molecular CardiologyCleveland ClinicClevelandUSA

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