Transcription Factors in Gastrointestinal Malignancies

  • Pallaval Veera Bramhachari
  • Ganji Purnachandra Nagaraju
Chapter

Abstract

Gastrointestinal cancer are complex diseases and most lethal amongst all other cancer types. Recent studies have revealed that transcriptional factors are ubiquitously expressed and modulates various physiological processes such as progression and metastasis in Gastrointestinal malignancies. Therefore, targeting these transcriptional factors is an important therapeutic strategy against cancer. In this book, we will discuss some of the important transcriptional factors in depth and further evaluate their role in Gastrointestinal malignancies.

Keywords

Gastrointestinal malignancies Transcription factors NF-κB HIF-1α AP1 E2-F1 STAT-3 

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Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  • Pallaval Veera Bramhachari
    • 1
  • Ganji Purnachandra Nagaraju
    • 2
  1. 1.Department of BiotechnologyKrishna UniversityMachilipatnamIndia
  2. 2.Department of Hematology and Medical Oncology, Winship Cancer InstituteEmory UniversityAtlantaUSA

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