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Approach, Application, and Bioethics of mtDNA Sequencing in Cancer

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Mitochondrial DNA and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1038))

Abstract

Mitochondrial DNA (mtDNA) is more vulnerable to mutations and associated with many solid tumors. Through mtDNA sequencing, we can find useful information on the mutations implicated in diseases and can better define the impact of mitochondrial dysfunction on the process of carcinogenesis. In current article, we will discuss the current approaches of mtDNA sequencing and the challenges we should overcome, their applications in various cancers, and the potential bioethics problems we should face in the application of mtDNA sequencing in clinical diagnosis and treatment.

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Acknowledgments

The work was supported by Zhongshan Distinguished Professor Grant (XDW), The National Nature Science Foundation of China (91230204, 81270099, 81320108001, 81270131, 81300010), The Shanghai Committee of Science and Technology (12JC1402200, 12431900207, 11410708600, 14431905100), Operation funding of Shanghai Institute of Clinical Bioinformatics, Ministry of Education for Academic Special Science and Research Foundation for PhD Education (20130071110043), and National Key Research and Development Program (2016YFC0902400, 2017YFSF090207).

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Authors and Affiliations

  1. Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Medical College, Shanghai, China

    Mengjia Qian & Xiangdong Wang

  2. Shanghai Institute of Clinical Bioinformatics, Shanghai, China

    Mengjia Qian & Claudio Spada

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  1. Mengjia Qian
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  2. Claudio Spada
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  3. Xiangdong Wang
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Correspondence to Xiangdong Wang .

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Editors and Affiliations

  1. Liaoning Province Key Laboratory of Cancer Metabolomics, Jinzhou Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China

    Hongzhi Sun

  2. Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Medical College, Shanghai, China

    Xiangdong Wang

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Qian, M., Spada, C., Wang, X. (2017). Approach, Application, and Bioethics of mtDNA Sequencing in Cancer. In: Sun, H., Wang, X. (eds) Mitochondrial DNA and Diseases. Advances in Experimental Medicine and Biology, vol 1038. Springer, Singapore. https://doi.org/10.1007/978-981-10-6674-0_3

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