Design and Scale-up of High-solid and Multi-phase Bioprocess

  • Hongzhang ChenEmail author
Part of the Green Chemistry and Sustainable Technology book series (GCST)


The rheological properties in high-solid and multi-phase system are different from that of ordinary fluids because of the high solid content. Thus, there is new requirement for solid-state reactor and large-scale solid materials conveyor devices. In this chapter, the rheological characteristics of high-solid enzymatic hydrolysis system were analyzed and the transfer and seepage laws in the porous solid medium were revealed. Agitation and intensification methods for the high-solid and multi-phase system were also studied. Based on the above, the high-solid and multi-phase reactor and corresponding large-scale conveyor devices were developed, and prospect for the engineering application and development direction of the high-solid and multi-phase bioprocess in the future were provided.


Rheological characteristics Mass transfer and seepage Solid-state reactor Mixing and strengthening method Large-scale conveyor devices 


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Institute of Process EngineeringChinese Academy of SciencesBeijingChina

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