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Role of Proteases in Regulating Cell Death Pathways

  • Thomas Divya
  • Sekar Vasudevan
  • Ganapasam Sudhandiran
Chapter

Abstract

Cell death is a critical process involved during development, tissue homeostasis, and aging. Multiple forms of cell death exist such as apoptosis (type I cell death), necrosis, and autophagy (type II cell death). Recently, other selective forms of cell death such as pyroptosis, eryptosis, entosis, mitophagy, and oncosis are also reported. These cell death pathways collaborate with each other, and regulation of such mechanisms is crucial for maintaining cellular homeostasis. Interestingly, proteases are the one that mediate the cell death programs, and immense research is focused on elucidating the mechanisms through which protease regulates cell death program. In this chapter, we focus on various cell death pathways and how protease regulates these pathways.

Keywords

Apoptosis Autophagy Proteases Necroptosis Cell death 

Notes

Acknowledgement

The authors thank the support of University Grants Commission (UGC)-UPE Phase II for carrying out a part of work in calcium signaling.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Thomas Divya
    • 1
  • Sekar Vasudevan
    • 1
  • Ganapasam Sudhandiran
    • 1
  1. 1.Cell Biology Laboratory, Department of BiochemistryUniversity of MadrasChennaiIndia

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