Updates on Stimuli-Responsive Polymers: Synthesis Approaches and Features
Stimuli-responsive polymers (SRPs) are a type of smart materials which can demonstrate noticeable changes in their characteristics as a response to their exposure to some environmental stimuli variations. The environmental stimuli could be physical (e.g., electric field, ionic strength, magnetic field, mechanical stress, pressure, radiation, and temperature), chemical (e.g., specific ions and chemical agents), or biochemical (e.g., enzyme substrates and ligands). Recently, SRPs were used in numerous applications including diagnostics, drug delivery systems, biosensors, regenerative medicine, and stem cells. This chapter illustrates the different categories of SRPs and highlights some of their synthesis approaches, unique features, major development, their different structures, and classifications.
KeywordsStimuli-responsive polymers SRPs Synthesis Classifications
- Kurisawa M, Chung JE, Yang YY, Gao SJ, Uyama H (2005) Injectable biodegradable hydrogels composed of hyaluronic acid-tyramine conjugates for drug delivery and tissue engineering. Chem Commun 4312–4314Google Scholar
- Lee K, Yoon J, Lee J, Kim S, Jung H, Kim S, Joh J, Lee H, Lee D, Lee S (2004) Sustained release of vascular endothelial growth factor from calcium-induced alginate hydrogels reinforced by heparin and chitosan. In: Transplantation proceedings, pp 2464–2465Google Scholar
- Li J, Ni X, Zhou Z, Leong KW (2003) Preparation and characterization of polypseudorotaxanes based on block-selected inclusion complexation between poly (propylene oxide)-poly (ethylene oxide)-poly (propylene oxide) triblock copolymers and alpha-cyclodextrin. J Am Chem Soc 125:1788–1795CrossRefPubMedGoogle Scholar
- Qiu Y, Park K (2012) Environment-sensitive hydrogels for drug delivery. Adv Drug Delivery RevGoogle Scholar
- Zhao S-P, Zhang L-M, Ma D (2006) Supramolecular hydrogels induced rapidly by inclusion complexation of poly (varepsilon-caprolactone)-poly (ethylene glycol)-poly (varepsilon-caprolactone) block copolymers with alpha-cyclodextrin in aqueous solutions. J Phys Chem B 110:12225–12229CrossRefPubMedGoogle Scholar