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Hydrogels pp 1-28 | Cite as

Intelligent Hydrogels as Drug Delivery Systems

  • Katarina Novakovic
  • Simon Matcham
  • Amy Scott
Chapter
Part of the Gels Horizons: From Science to Smart Materials book series (GHFSSM)

Abstract

A drug delivery system (DDS) can be defined as a formulation or a device that facilitates the release of a therapeutic substance in the body. Key parameters of interest in DDS are safety, delivery rate, efficiency, as well as time and place of release of drugs. Lately, hydrogels have attracted significant attention for application in drug delivery. Hydrogels are three-dimensional polymer networks consisting largely of water. They are characterised by a porous structure with porosity, pore size and geometry that can be varied during the hydrogel synthesis. Importantly, due to porous structure they have the ability to incorporate biomolecules.

References

  1. AAO (2014) Tear duct implant effective at reducing pain and inflammation in cataract surgery patients. American Academy of OpthalmologyGoogle Scholar
  2. Al-Ahmady ZS, Al-Jamal WT, Bossche JV, Bui TT, Drake AF, Mason AJ, Kostarelos K (2012) Lipid-peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia in vitro and in vivo. ACS Nano 6:9335–9346CrossRefPubMedPubMedCentralGoogle Scholar
  3. Annabi N, Nichol JW, Zhong X, Li C, Koshy S, Khademhosseini A, Dehghani F (2010) Controlling the porosity and microarchitecture of hydrogels for tissue engineering. Tissue Eng Part B Rev 16(4):371–383CrossRefPubMedPubMedCentralGoogle Scholar
  4. Azab AK, Kleinstern J, Doviner V, Orkin B, Srebnik M, Nissan A, Rubinstein A (2007) Prevention of tumor recurrance and distant metastasis formation in a breast cancer mouse model by biodegradable implant of I-Norcholestrol. J Control Release 123:116–122CrossRefPubMedGoogle Scholar
  5. Barron V, Killion JA, Pilkington L, Burke G, Geever LM, Lyons JG, McCullagh E, Higginbotham CL (2016) Development of chemically cross-linked hydrophillic-hydrophobic hydrogels for drug delivery applications. Eur Polym J 75:25–35Google Scholar
  6. Begam T, Nagpal AK, Singhal R (2003) A comparative study of swelling properties of hydrogels based on poly(acrylamide-co-metyl methacrylate) containing physical and chemical crosslinks. J Appl Polym Sci 89:779–786CrossRefGoogle Scholar
  7. Berkowitz WF, Choudhry SC, Hrabie JA (1982) Conversion of asperuloside to optically active prostaglandin intermediates. J Org Chem 47(5):824–829CrossRefGoogle Scholar
  8. Bhattarai N, Gunn J, Zhang M (2010) Chitosan-based hydrogels for controlled, localized drug delivery. J Adv Drug Deliv Rev 62(1):83–99CrossRefGoogle Scholar
  9. Bierbrauer F (2005) Hydrogel drug delivery: diffusion models, internal report. School of Mathematics and Applied Statistics, University of Wollongong, Australia. www.bierbrauerf.weebly.com
  10. Bonini C, Iavarone C, Trogolo C, Fabio RD (1984) One-pot conversion of 6-hydroxy-Δ7-iridoid glucosides into cis-2-oxabicyclo[3.3.0]oct-7-enes and transformation into corey’s lactone analogue. J Org Chem 50(7):958–981CrossRefGoogle Scholar
  11. Braithwaite G (2013) Hydrogels, polymers and plastics in medical devices. Boston, MA, USA. www.campoly.com/educational-resources/presentations/
  12. Butler MF, Ng Y-F, Pudney PDA (2003) Mechanism and kinetics of the crosslinking reaction between biopolymers containing primary amine groups and genipin. J Polym Sci 41(24):3941–3953CrossRefGoogle Scholar
  13. Butler MF, Clark AH, Adams S (2006) Swelling and mechanical properties of biopolymer hydrogels containing chitosan and bovine serum albumin. Biomacromol 7(11):2961–2970CrossRefGoogle Scholar
  14. Caló E, Khutoryanskiy VV (2015) Biomedical applications of hydrogels: a review of patents and commercial products. Eur Polymer J 65:252–267CrossRefGoogle Scholar
  15. Cao X, Lai S, Lee LJ (2001) Design of a self-regulated drug delivery device. Biomed Microdevice 3(2):109–118CrossRefGoogle Scholar
  16. Chen J, Blevins WE, Park H, Park K (2000) Gastric retention properties of superporous hydrogel composites. J Control Release 64(1–3):39–61CrossRefPubMedGoogle Scholar
  17. Chen H, Ouyang W, Lawuyi B, Martoni C, Prakesh S (2005) Reaction of chitosan with genipin and its fluorogenic attributes for potential microcapsule membrane characterization. J Biomed Mater Res 75A(4):917–927CrossRefGoogle Scholar
  18. Delgadillo-Amendariz NL, Rangel-Vazquez NA, Marquez-Brazon EA, Rojas-DeGascue B (2014) Interactions of chitosan/genipin hydrogels during drug delivery: a QSPR approach. Quim Nova 37(9):1503–1509Google Scholar
  19. Delmar K, Bianco-Peled H (2015) The dramatic effect of small pH changes on the properties of chitosan hydrogels crosslinked with genipin. Carbohyd Polym 127Google Scholar
  20. Dimida S, Demitri C, Benedictis VMD, Scalera F, Gervaso F, Sannino A (2015) Genipin-cross-linked chitosan-based hydrogels: reaction kinetics and structure-related characterstics. J Appl Polym Sci 132(28):1–8CrossRefGoogle Scholar
  21. Djekic L, Martinovic M, Stepanovic-Petrovic R, Micov A, Tomic M, Primorac M (2016) Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of Ibuprofen assessed in vivo in rats. Eur J Pharm SciGoogle Scholar
  22. Djerassi C, Gray JD, Kincl FA (1960) Naturally occurring oxygen heterocyclics. IX. Isolation and characterisation of genipin. J Org Chem 25(12):2174–2177CrossRefGoogle Scholar
  23. Dong L, Agarwal AK, Beebe DJ, Jiang H (2006) Adaptive liquid microlenses activated by stimuli-responsive hydrogels. Nature 442:551–554CrossRefPubMedGoogle Scholar
  24. Drury JL, Mooney DJ (2003) Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials 24:4337–4351CrossRefGoogle Scholar
  25. Ebara M, Kotsuchibash Y, Narain R, Idota N, Kim Y-J, Hoffman JM, Aoyagi T (2014) Smart biomaterials. Springer, Tsukuba, JapanCrossRefGoogle Scholar
  26. Endo T, Taguchi H (1973) The constituents of gardenia jasminoides geniposide and genipin-gentibioside. Chem Pharm Bull 21:2684–2688CrossRefGoogle Scholar
  27. Felt O, Furrer P, Mayer JM, Plazonnet B, Buri P, Gurny R (1999) Topical use of chitosan in ophthalmology: tolerance assessment and evaluation of precorneal retention. Int J Pharm 180:185–193CrossRefPubMedGoogle Scholar
  28. Fiamingo A, Campana-Filho SP (2016) Structure, morphology and properties of genipin-crosslinked carbomethylchitosan porous membranes. Carbohyd Polym 143(1):155–163CrossRefGoogle Scholar
  29. Fujikawa S, Yokota T, Koga J (1987) The continuous hydrolysis of geniposide to genipin using immobilized β-glucosidae on calcium alginate gel. Biotech Lett 9(10):687–702CrossRefGoogle Scholar
  30. Funami T, Hiroe M, Noda S, Asai I, Ikeda S, Nishinari K (2007) Influence of molecular structure imaged with atomic force microscopy on the rheological behaviour of carrageenan aqueous systems in the presence or absence of cations. Food Hydrocolloids 21(1):617–629CrossRefGoogle Scholar
  31. Galaev IY, Mattiasson B (1999) Smart polymers and what they could do in biotechnology and medicine. Trends Biotechnol 17(1):335–340CrossRefPubMedPubMedCentralGoogle Scholar
  32. Ganji F, Vasheghani-Farahani S, Vasheghani-Farahani E (2010) Theoretical description of hydrogel swelling: a review. Iran Polym J 19(5):275–298Google Scholar
  33. Gao L, Gan H, Meng Z, Gu R, Wu Z, Zhang L, Zhu X, Sun W, Li J, Zheng Y, Dou G (2014) Effects of genipin cross-linking of chitosan hydrogels on cellular adhesion and viability. Colloids Surf B 117(1):398–405CrossRefGoogle Scholar
  34. Gou M, Li X, Dai M, Gong C, Wang X, Xie Y, Deng H, Chen L, Zhao X, Qian Z, Wei Y (2008) A novel injectable local hydrophobic drug delivery system: biodegradable nanoparticles in thermo-sensitive hydrogel. Int J Pharm 359:228–233CrossRefPubMedGoogle Scholar
  35. Gulrez SKH, Al-Assaf S, Phillips GO (2011) Hydrogels: methods of preparation, characterisation and applications. In: Carpi A (ed) Progress in molecular and environmental bioengineering—from analysis and modeling to technology applications. Hydrocolloids Research Centre, Wrexham, UKGoogle Scholar
  36. Gupta P, Vermani K, Garg S (2002) Hydrogels: from controlled release to pH-responsive drug delivery. Drug Dis Today 7(10):569–579CrossRefGoogle Scholar
  37. Hamidi M, Azadi A, Rafiei P (2008) Hydrogel nanoparticles in drug delivery. Adv Drug Deliv Rev 60:1638–1649CrossRefPubMedGoogle Scholar
  38. Hassan CM, Peppas NA (2000) Structure and morphology of freeze/thawed PVA hydrogels. Macromolecules 33(1):2472–2479CrossRefGoogle Scholar
  39. Hennink WE, Nostrum CF (2002) Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev 54(1):13–36Google Scholar
  40. Hoare TR, Kohane DS (2008) Hydrogels in drug delivery: progress and challenges. Polymer 49(8):1993–2007CrossRefGoogle Scholar
  41. Hoffman AS (2012) Hydrogels for biomedical applications. Adv Drug Deliv Rev 64:18–23CrossRefGoogle Scholar
  42. Holowka EP, Bhatia SK (2014) Drug delivery: materials design and clinical perspective. Springer, New YorkCrossRefGoogle Scholar
  43. Hurst G, Novakovic K (2013) A facile in situ morphological characterization of smart genipin-crosslinked chitosan-poly(vinyl pyrrolidone) hydrogels. J Mater Res 28(17):2401–2408CrossRefGoogle Scholar
  44. Jabeen S, Maswal M, Chat OA, Rather GM, Dar AA (2016) Rheological behaviour and Ibuprofen delivery applications of pH responsive composite alginate hydrogels. Colloids Surf B Biointerfaces 139:211–218Google Scholar
  45. Jiang Y, Chen J, Deng C, Suuronen EJ, Zhong Z (2014) Click hydrogels, microgels and nanogels: emerging platforms for drug delivery and tissue engineering. Biomaterials 35:4969–4985CrossRefPubMedGoogle Scholar
  46. Jiao Y, Liu Z, Ding S, Li L, Zhou C (2006) Preparation of biodegradable crosslinking agents and application in PVP hydrogel. J Appl Polym Sci 101(3):1515–1521CrossRefGoogle Scholar
  47. Khademhosseini A, Langer R (2007) Microengineered hydrogels for tissue engineering. Biomaterials 28:5087–5092CrossRefPubMedGoogle Scholar
  48. Kharlampieva E, Erel-Unal I, Sukhishvili SA (2007) Amphoteric surface hydrogels derived from hydrogen-bonded multilayers: reversible loading of dyes and macrmolecules. Langmuir 23(1):175–181CrossRefPubMedGoogle Scholar
  49. Koren E, Apte A, Jani A, Torchilin VP (2012) Mulitfunctional PEGylated 2C5-immunoliposomes containing pH-sensitive bonds and TAT peptide for enhanced tumor cell internalization and cytotoxicity. J Control Release 160:264–273CrossRefPubMedGoogle Scholar
  50. Lee BP, Konst S (2014) Novel hydrogel actuator inspired by reversible mussel adhesive protein chemistry. Adv Mater 26(21):3415–3419CrossRefPubMedGoogle Scholar
  51. Lee KY, Mooney DJ (2001) Hydrogels for tissue engineering. Chem Rev 101(7):1869–1879CrossRefPubMedGoogle Scholar
  52. Lee Y, Chung H, Yeo S, Ahn C-H, Lee H, Messersmith PB, Park TG (2010) Thermo-sensitive, injectable, and tissue adhesive sol-gel transition hyaluronic acid/pluronic composite hydrogels prepared from bio-inspired catechol-thiol reaction. Soft Matter 6:977–983CrossRefGoogle Scholar
  53. Li Y, Rodrigues J, Tomás H (2012) Injectable and biodegradable hydrogels: gelation, biodegredation and biomedical applications. Chem Soc Rev 41:2193–2221CrossRefPubMedGoogle Scholar
  54. Liu T-Y, Lin Y-L (2010) Novel pH-sensitive chitosan-based hydrogel for encapsulating poorly water-soluble drugs. Acta Biomater 6(4):1423–1429CrossRefPubMedGoogle Scholar
  55. Magnin D, Lefebvre J, Chornet E, Dumitriu S (2004) Physiological and structural characterisation of a polyanionic matrix of interest in biotechnology, in the pharmaceutical and biomedical fields. Carbohyd Polym 55(4):437–453CrossRefGoogle Scholar
  56. Mahajan A, Aggarwal G (2011) Smart polymers: innovations in novel drug delivery. Int J Drug Dev Res 3(3):16–30Google Scholar
  57. Maitra J, Shukla VK (2014) Cross-linking in hydrogels—a review. Am J Polym Sci 4(2):25–31Google Scholar
  58. Mann BK, Gobin AS, Tsai AT, Scmedlen RH, West JL (2001) Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. Biomaterials 22:3045–3051CrossRefPubMedGoogle Scholar
  59. Martin L, Wilson CG, Koosha F, Uchegbu IF (2003) Sustained buccal delivery of the hydrophobic drug denbufylline using physically cross-lined palmitoyl glycol chitosan hydrogels. Eur J Pharm Biopharm 55:35–43CrossRefPubMedGoogle Scholar
  60. Maskare R, Bajaj A, Jain D, Braroo P, Babul N, Kao H (2013) Hydrogel-thickened nanoemulsions for topical administration of Ibuprofen. J Pain 14(4):S86CrossRefGoogle Scholar
  61. Matcham S, Novakovic K (2016) Fluorescence imaging in genipin crosslinked chitosan–poly(vinyl pyrrolidone) hydrogels. Polymers 8:385CrossRefGoogle Scholar
  62. McKenzie M, Betts D, Suh A, Bui K, Kim LD, Cho H (2015) Hydrogel-based drug delivery systems for poorly water-soluble drugs. Molecules 20:20397–20408CrossRefPubMedGoogle Scholar
  63. Mi F-L, Syu S-S, Peng C-K (2005) Characterization of ring-opening polymerization of genipin and pH-dependent cross-linking reactions between chitosan and genipin. J Polym Sci 43(10):1985–2000CrossRefGoogle Scholar
  64. Moura J, Figueiredo M, Gil H (2007) Rheological study of genipin cross-linked chitosan hydrogels. Biomacromol 8:3823–3829CrossRefGoogle Scholar
  65. Muzzarelli RAA (2009) Genipin-crosslinked chitosan hydrogels as biomedical and pharmaceutical aids. Carbohyd Polym 77(1):1–9CrossRefGoogle Scholar
  66. Muzzarelli RAA, Mehtedi ME, Bottegoni C, Aquili A, Gigante A (2015) Genipin-crosslinked chitosan gels and scaffolds for tissue engineering and regeneration of cartilage and bone. Mar Drugs 13(12):7314–7338CrossRefPubMedPubMedCentralGoogle Scholar
  67. Muzzarelli RAA, Mehtedi ME, Bottegoni C, Gigante A (2016) Physical properties imparted by genipin to chitosan for tissue regeneration with human stem cells. Int J Biol Macromol.  https://doi.org/10.1016/j.ijbiomac.2016.03.075CrossRefPubMedGoogle Scholar
  68. Naruto M, Ohno K, Naruse N (1978) The synthesis of useful chiral prostanoid intermediates and naturally occurring prostaglandins from aucubin. Chem Lett, 1419–1422Google Scholar
  69. Nichols JJ (2013) Contact Lenses 2012. Contact Lenses Spectrum 28:24–29. https://www.clspectrum.com/issues/2013/january-2013/contact-lenses-2012Google Scholar
  70. Ninawe PR, Parulekar SJ (2011) Drug loading into and drug release from pH- and temperature-responsive cylindrical hydrogels. Biotechnol Prog 27(5):1442–1454CrossRefPubMedGoogle Scholar
  71. Nguyen KT, West JL (2002) Photopolymerizable hydrogels for tissue engineering applications. Biomaterials 23:4307–4314CrossRefPubMedPubMedCentralGoogle Scholar
  72. NHS: Blood and Transplant (2015) Organ donation and transplantation: activity report 2014/15. NHSGoogle Scholar
  73. Nwosu CJ, Hurst GA, Novakovic K (2015) Genipin cross-linked chitosan-polyvinylpyrrolidone hydrogels: influence of composition and postsynthesis treatment on pH responsive behaviour. Adv Mat Sci Eng 1–10Google Scholar
  74. Oh JK, Drumright R, Siegwart DJ, Matyjaszewski K (2008) The development of microgels/nanogels for drug delivery applications. Prog Polym Sci 33:448–477CrossRefGoogle Scholar
  75. Organ Donation (2015) NHS blood and transplant reveals nearly 49,000 people in the UK have had to wait for a transplant in the last decade. www.organdonation.nhs.uk/news-and-campaigns/news/nhs-blood-and-transplant-reveals-nearly-49-000-people-in-the-uk-have-had-to-wait-for-a-transplant-in-the-last-decade/
  76. Ottenbrite RM, Park K, Okano T (2010) Biomedical applications of hydrogels handbook. SpringerGoogle Scholar
  77. Ozeki T, Hashizawa K, Kaneko D, Imai Y, Okada H (2010) Treatment of rat brain tumors using sustained-release of camptothecin from poly(lactic-co-glycolic-acid) microspheres in a thermoreversible hydrogel. Chem Pharm Bull 58(9):1142–1147CrossRefPubMedGoogle Scholar
  78. Paik Y-S, Lee C-M, Cho M-H, Hahn T-R (2001) Physical stability of the blue pigments formed from geniposide of gardenia fruits: effects of pH, temperature, and light. J Agric Food Chem 49(1):430–432CrossRefPubMedGoogle Scholar
  79. Paranhos CM, Oliveira RN, Soares BG, Pessan LA (2007) Poly(vinyl alcohol)/sulfonated polyester hydrogels produced by freezing and thawing technique: preparation and characterisation. Mat Res 10(1):43–46CrossRefGoogle Scholar
  80. Park K (1988) Enzyme-digestible swelling hydrogels as platforms for long-term oral drug delivery: synthesis and characterization. Biomaterials 9(5):435–441CrossRefPubMedGoogle Scholar
  81. Park J-E, Lee J-Y, Kim H-G, Hahn T-R, Paik Y-S (2002) Isolation and characterization of water-soluble intermediates of blue pigments transformed from geniposide of gardenia jaminoides. J Agric Food Chem 50(22):6511–6514CrossRefPubMedGoogle Scholar
  82. Peng K, Tomatsu I, Kros A (2011) Hydrogel-based drug carries for controlled release of hyrdrophobic drugs and proteins. J Controll Release 152(1):e72–e74CrossRefGoogle Scholar
  83. Peppas NA, Bures P, Leobandung W, Ichikawa H (2000) Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 50(1):27–46CrossRefPubMedPubMedCentralGoogle Scholar
  84. Peppas NA, Hilt JZ, Khademhosseini A, Langer R (2006) Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Adv Mater 18:1345–1360CrossRefGoogle Scholar
  85. Petta D, Fussell G, Hughes L, Buechter DD, Sprecher CM, Alini M, Eglin D, D’Este M (2016) Calcium phosphate/thermoresponsive hyaluronan hydrogel composite delivering hydrophilic and hydrophobic drugs. J Orthopaedic Transl 6:57–68CrossRefGoogle Scholar
  86. Phillips GO, Williams PA (2009) Handbook of hydrocolloids, 2nd edn. Woodhead Publishing, UKCrossRefGoogle Scholar
  87. Qiu Y, Park K (2001) Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev 53:321–339CrossRefPubMedGoogle Scholar
  88. Rainsford KD (2012) Ibuprofen: pharmacology, therapeutics and side effects. Springer, SheffieldCrossRefGoogle Scholar
  89. Rapoport NY, Kennedy AM, Shea JE, Scaife CL, Nam KH (2009) Controlled and targeted tumour chemotherapy by ultrasound-activated nanoemulsions/microbubbles. J Controll Release 138:268–276CrossRefGoogle Scholar
  90. Robitaille M, Shi J, McBride S, Wan K-T (2013) Mechanical performance of hydrogel contact lenses with a range of power under parallel plate compression and central load. J Mech Behav Biomed Mat 22:59–64CrossRefGoogle Scholar
  91. Roldan JE (2003) Hydrogels: introduction and applications in biology and engineering. Department of Biological Sciences, Louisiana Tech University, LouisianaGoogle Scholar
  92. Roughley P, Hoemann C, DesRosiers E, Mwale F, Antoniou J, Alini M (2006) The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation. Biomaterials 27:388–396CrossRefPubMedGoogle Scholar
  93. Sakthivel M, Franklin DS, Guhanathan S (2015) Intelligent hydrogels for controlled drug delivery system: a review. Int J Front Sci Technol 3(2):37–47Google Scholar
  94. Schroeder A, Goldberg MS, Kastrup C, Wang Y, Jiang S, Joseph BJ, Levins CG, Kannan ST, Langer R, Anderson DG (2012) Remotely activated protein-producing nanoparticles. Nano Lett 12:2685–2689CrossRefPubMedPubMedCentralGoogle Scholar
  95. Sharma A, Pandey R, Sharma S, Khuller GK (2004) Chemotherapeutic efficacy of poly(dl-lactide-co-glycolide) nanoparticle encapsulated antitubercular drugs at sub-therapeutic dose against experimental tuberculosis. Int J Antimicrob Agents 24(6):599–604CrossRefPubMedGoogle Scholar
  96. Sharpe LA, Daily AM, Horava SD, Peppas NA (2014) Therapeutic applications of hydrogels in oral drug delivery. Expert Opin Drug Deliv 11(6):901–915Google Scholar
  97. Shin J, Han SG, Lee W (2012) Dually tunable inverse optical hydrogel colorimetric sensor with fast and reversible color changes. Sens Actuactors B Chem 168:20–26CrossRefGoogle Scholar
  98. Stashak TS, Farstvedt E, Othic A (2004) Update on wound dressing: indications and best use. Clin Tech Equine Pract 3(2):148–163CrossRefGoogle Scholar
  99. Sung HW, Huang RN, Huang LL, Tsai CC (1999) In vitro cytotoxicity of a naturally occurring cross-linking reagent for biological tissue formation. J Biomat Sci Polym Ed 10(1):63–78CrossRefGoogle Scholar
  100. Tang C, Guan Y-X, Yao S-J, Zhu Z-Q (2014) Preparation of Ibuprofen-loaded chitosan films for oral mucosal drug delivery using supercritical solution impregnation. Int J Pharm 473(1–2):434–441CrossRefPubMedGoogle Scholar
  101. Torres AJ, Zhu C, Shuler ML (2011) Paclitaxel delivery to brain tumors from hydrogels: a computational study. Biotechnol Prog 27(5):1478–1487CrossRefPubMedGoogle Scholar
  102. Trevor SL, Butler MF, Adams S, Laity PR, Burley JC, Cameron RE (2008) Structure and phase transitions of genipin, an herbal medicine and naturally occurring cross-linker. Cryst Growth Des 8(5):1748–1753CrossRefGoogle Scholar
  103. Tsai T-R, Tseng T-Y, Chen C-F, Tsai T-H (2002) Identification and determination of geniposide contained in gardenia jaminoides and in two preparations of mixed traditional chinese medicines. J Chromatogr A 961(1):83–88CrossRefPubMedGoogle Scholar
  104. van der Linden HJ, Herber S, Olthuis W, Bergveld P (2003) Stimulus-sensitive hydrogels and their applications in chemical (micro)analysis. Analyst 128(4)Google Scholar
  105. Vashist A, Vashist A, Gupta YK, Ahmad S (2014) Recent advances in hydrogel based drug delivery systems for the human body. J Mat Chem B 2:147–166CrossRefGoogle Scholar
  106. Vozzi G, Corallo C, Carta S, Fortina M, Gattazzo F, Galletti M, Giordano N (2013) Collagen-gelatin-genipin-hydroxyapatite composite scaffolds colonized by human primary osteoblasts are suitable for bone tissue engineering applications: in vitro evidences. J Biomed Mat Res A 102(5):1415–1421CrossRefGoogle Scholar
  107. Wang Y, Lu Z, Han Y, Feng Y, Tang C (2011) A novel thermoviscosifying water-soluble polymer for enhancing oil recovery from high-temperature and high-salinity oil resevoirs. Adv Mat Res 306:654–657Google Scholar
  108. Wang J, Wang L, Yu H, Zain-Ul-Abdin, Chen Y, Chen Q, Zhou W, Zhang H, Chen X (2016) Recent progress on synthesis, property and application of modified chitosan: an overview. Int J Biol Macromol 88:333–334Google Scholar
  109. Watkins KA, Chen R (2015) pH-responsive, lysine-based hydrogels for the oral delivery of a wide szie range of molecules. Int J Pharm 478(2):496–503CrossRefPubMedGoogle Scholar
  110. Wei C-S, Kim C, Kim H-J, Limsakul P (2012) Hydrogel drug delivery: diffusion modelsGoogle Scholar
  111. Xiao Z, Ji C, Shi J, Pridgen EM, Frieder J, Wu J, Farokhzad OC (2012) DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy. Angew Chem Int Ed 54:11853–11857CrossRefGoogle Scholar
  112. Yan Q, Yuan J, Cai Z, Xin Y, Kang Y, Yin Y (2010) Voltage-responsive vesicles based on orthgonal assembly of two homopolymers. J Am Chem Soc 132:9268–9270CrossRefPubMedGoogle Scholar
  113. Ye Y, Hu X (2016) A pH-sensitive injectable nanoparticle composite hydrogel for anticancer drug delivery. J Nanomat 1–8Google Scholar
  114. Yu Q, Bauer JM, Moore JS, Beebe DJ (2001) Responsive biomimetic hydrogel valve for microfluidics. Appl Phys Lett 78:2589–2591CrossRefGoogle Scholar
  115. Zhang C-Y, Parton LE, Ye CP, Krauss S, Shen R, Lin C-T, Porco Jr JA, Lowell BB (2006) Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity—and high glucose-induced β cell dysfunction in isolated pancreatic islets. Cell Metab 3(6):417–427Google Scholar

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.School of Chemical Engineering and Advanced MaterialsNewcastle UniversityNewcastle upon TyneUK

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