Epidemiological Aspects of Photocarcinogenesis

  • Neera Yadav
  • Monisha BanerjeeEmail author


Epidemiologically, it is hard to distinct the effects of component radiations because sunlight is considered as a whole entity. Human skin may experience either acute (immediate reaction) or chronic (repeated) sunlight exposure. UV radiation coming through sunlight is absorbed by human skin and causes various degrees of damage. However, melanin pigment in the skin acts as a natural sunscreen and absorbs and prevents from detrimental consequences of UV radiation. Repeated and extended UV exposure causes development of photoaging, i.e., premature skin aging and photocarcinogenesis. Photo-induced cancers particularly include malignant melanomas and carcinomas, i.e., basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). High-UV radiation environment leads to evolution of permanently dark constitutive pigmentation which is resistant to UV radiation. However, light-skinned people experience premature skin aging on repeated exposure. Therefore, prevalence of photocarcinogenesis is highest in lightly pigmented people (Halder and Bridgeman-Shah: Cancer 75(S2):667–673, 1995). Development of photocarcinogenesis is dependent on various factors including ethnic origin, place of residence, anatomic site exposed, outdoor and indoor activities, total exposure duration, time of exposure, and ambient sunlight intensity. Photocarcinogenesis is predominantly a disease of people of European origin. Its rate is very low in Asia and in the United States. It is more frequently observed in white-skinned than dark-skinned people.


Epidemiology Radiation Melanin Photocarcinogenesis Carcinoma 


  1. 1.
    Battie C, Verschoore M (2012) Cutaneous solar ultraviolet exposure and clinical aspects of photodamage. Indian J Dermatol Venereol Leprol 78(7):9CrossRefGoogle Scholar
  2. 2.
    Whiteman DC, Watt P, Purdie DM, Hughes MC, Hayward NK, Green AC (2003) Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma. J Natl Cancer Inst 95(11):806–812CrossRefGoogle Scholar
  3. 3.
    D’Orazio J, Jarrett S, Amaro-Ortiz A, Scott T (2013) UV radiation and the skin. Int J Mol Sci 14(6):12222–12248CrossRefGoogle Scholar
  4. 4.
    Wang SQ, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS (2001) Ultraviolet A and melanoma: a review. J Am Acad Dermatol 44(5):837–846CrossRefGoogle Scholar
  5. 5.
    Pittayapruek P, Meephansan J, Prapapan O, Komine M, Ohtsuki M (2016) Role of matrix metalloproteinases in photoaging and photocarcinogenesis. Int J Mol Sci 17(6):868CrossRefGoogle Scholar
  6. 6.
    Bosch R, Philips N, Suárez-Pérez JA, Juarranz A, Devmurari A, Chalensouk-Khaosaat J, González S (2015) Mechanisms of photoaging and cutaneous photocarcinogenesis, and photoprotective strategies with phytochemicals. Antioxidants 4(2):248–268CrossRefGoogle Scholar
  7. 7.
    Chu CY, Cha ST, Chang CC, Hsiao CH, Tan CT, Lu YC, Jee SH, Kuo ML (2007) Involvement of matrix metalloproteinase-13 in stromal-cell-derived factor 1 [alpha]-directed invasion of human basal cell carcinoma cells. Oncogene 26(17):2491CrossRefGoogle Scholar
  8. 8.
    Prasad NB, Fischer AC, Chuang AY, Wright JM, Yang T, Tsai HL, Westra WH, Liegeois NJ, Hess AD, Tufaro AP (2014) Differential expression of degradome components in cutaneous squamous cell carcinomas. Mod Pathol: Off J U S Can Acad Pathol Inc 27(7):945CrossRefGoogle Scholar
  9. 9.
    Leight JL, Tokuda EY, Jones CE, Lin AJ, Anseth KS (2015) Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition. Proc Natl Acad Sci 112(17):5366–5371CrossRefGoogle Scholar
  10. 10.
    Harris NR, Kyrö E, Staehelin J, Brunner D, Andersen SB, Godin-Beekmann S, Dhomse S, Hadjinicolaou P, Hansen G, Isaksen I Jrrar A (2008) Ozone trends at northern mid-and high latitudes–a European perspective. Ann Geophys 26(5):1207–1220. Copernicus Publications on behalf of the European Geosciences Union, GermanyGoogle Scholar
  11. 11.
    Koepke P, Mech M (2005) UV irradiance on arbitrarily oriented surfaces: variation with atmospheric and ground properties. Theor Appl Climatol 81(1):25–32CrossRefGoogle Scholar
  12. 12.
    Roberts DF, Kahlon DPS (1976) Environmental correlations of skin colour. Ann Hum Biol 3(1):11–22CrossRefGoogle Scholar
  13. 13.
    Slominski A, Tobin DJ, Shibahara S, Wortsman J (2004) Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 84(4):1155–1228CrossRefGoogle Scholar
  14. 14.
    Nan H, Kraft P, Hunter DJ, Han J (2009) Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians. Int J Cancer 125(4):909–917CrossRefGoogle Scholar
  15. 15.
    Ricotti C, Bouzari N, Agadi A, Cockerell CJ (2009) Malignant skin neoplasms. Med Clin N Am 93(6):1241–1264CrossRefGoogle Scholar
  16. 16.
    MacKie RM, Hauschild A, Eggermont AMM (2009) Epidemiology of invasive cutaneous melanoma. Ann Oncol 20(suppl_6):vi1–vi7PubMedPubMedCentralGoogle Scholar
  17. 17.
    Bellew S, Del Rosso JQ, Kim GK (2009) Skin cancer in asians: part 2: melanoma. J Clin Aesthet Dermatol 2(10):34PubMedPubMedCentralGoogle Scholar
  18. 18.
    Marks R, Staples M, Giles GG (1993) Trends in non-melanocytic skin cancer treated in Australia: the second national survey. Int J Cancer 53(4):585–590CrossRefGoogle Scholar
  19. 19.
    Johnson-Obaseki SE, Labajian V, Corsten MJ, McDonald JT (2015) Incidence of cutaneous malignant melanoma by socioeconomic status in Canada: 1992–2006. J Otolaryngol-Head Neck Surg 44(1):53CrossRefGoogle Scholar
  20. 20.
    Gallagher RP, Hill GB, Bajdik CD, Fincham S, Coldman AJ, McLean DI, Threlfall WJ (1995) Sunlight exposure, pigmentary factors, and risk of nonmelanocytic skin cancer: I. Basal cell carcinoma. Arch Dermatol 131(2):157–163CrossRefGoogle Scholar
  21. 21.
    Vågero D, Ringbäck G, Kiviranta H (1986) Melanoma and other tumors of the skin among office, other indoor and outdoor workers in Sweden 1961–1979. Br J Cancer 53(4):507–512Google Scholar
  22. 22.
    Kricker A, Armstrong BK, English DR (1994) Sun exposure and non-melanocytic skin cancer. Cancer Causes Control 5(4):367–392CrossRefGoogle Scholar
  23. 23.
    Allen M, McKenzie R (2005) Enhanced UV exposure on a ski-field compared with exposures at sea level. Photochem Photobiol Sci 4(5):429–437CrossRefGoogle Scholar
  24. 24.
    Halder RM, Bridgeman-Shah S (1995) Skin cancer in african americans. Cancer 75(S2):667–673CrossRefGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Molecular and Human Genetics Laboratory, Department of ZoologyUniversity of LucknowLucknowIndia

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