UVR-Induced Epigenetic Regulation and Photocarcinogenesis
The human skin remains under constant exposure of solar radiation and is vulnerable to epigenetic modifications that later may develop skin cancer. The effects of chronic UVR exposure to skin can alter epigenetic information in epidermal cells, leading to epigenetic mosaicism. These epigenetic changes include DNA methylation, chromatin modifications, and posttranscriptional modifications of noncoding RNAs. UVR-induced epigenetic changes are not irreversible. Certain phytochemicals can potentially inhibit cancer signaling pathways which are usually deregulated by epigenetic mechanisms. Indeed, recent therapeutic strategies are directing toward phytochemical-based reversal of epigenetic modifications to combat UVR-induced skin cancers. This chapter provides detailed insights of different epigenetic alterations, their role in photocarcinogenesis, and phytochemical-based reversal of epigenetic changes occurring in UVR-irradiated skin.
KeywordsUltraviolet MicroRNA Histone DNA methylation Phytochemicals
- 1.O’Shaughnessy JA, Kelloff GJ, Gordon GB, Dannenberg AJ, Hong WK, Fabian CJ, Sigman CC, Bertagnolli MM, Stratton SP, Lam S, Nelson WG (2002) Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development: recommendations of the American Association for Cancer Research Task Force on the Treatment and Prevention of Intraepithelial Neoplasia. Clin Cancer Res 8(2):314–346PubMedGoogle Scholar
- 19.Dziunycz P, Iotzova-Weiss G, Eloranta JJ, Läuchli S, Hafner J, French LE, Hofbauer GF (2010) Squamous cell carcinoma of the skin shows a distinct microRNA profile modulated by UV radiation. J Investig Dermatol 130(11):2686Google Scholar
- 21.Connelly CM, Thomas M, Deiters A (2012) High-throughput luciferase reporter assay for small-molecule inhibitors of microRNA function. J Biomol Screen 17(6):822–828Google Scholar