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Protective Role of Phytochemicals Against UVR

  • Deepti Chopra
  • Jyoti Singh
  • Ajeet Kumar Srivastav
  • Divya Dubey
  • Ratan Singh Ray
  • Kailash Chand Gupta
Chapter

Abstract

Solar ultraviolet radiation (UVR) is a known environmental skin aggressor and main causative agent of most types of skin cancer. Skin is the physiological barrier that defends against both pathogens and chemical/physical damage. Sunlight exposure to skin may cause cellular oxidative damage and mutilation of antioxidant machinery. UVR is the key element responsible for photoageing. Photoprotection is therefore essential to avoid such undesired instances of UVR. In day to day life, the use of sunscreens has come up as the best photoprotective prerequisite. Apart from the sunscreens, special emphasis is on the use of chemicals of natural origin having photoshielding, antioxidant, radical scavenging or repair properties. Key classes of beneficial phytochemicals include phenolic acids, flavonoids, polyphenols, tea polyphenols, curcumin, resveratrol, etc. These phytochemicals are able to modulate apoptotic machinery (Bax, Caspase-3, Caspase-9, APAF-1) towards cell survival pathways (Bcl-2, PI3/AKT, mitogen-activated kinases). Several studies of medical importance have revealed that phytochemicals proceed through several molecular and cellular mechanisms to impediment or check photocarcinogenesis and photoageing. Therefore, it is very much needed to explore more photoprotective phytochemicals and understand their molecular mechanism to prevent UVR-induced damage.

Keywords

Phytochemicals Photoprotection Photoageing Ultraviolet radiation Apoptosis 

Notes

Acknowledgements

KC Gupta thanks the Indian Council of Medical Research (ICMR), New Delhi, India, for awarding Dr. A.S. Paintal Distinguished Scientist Chair at CSIR-IGIB, New Delhi.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Deepti Chopra
    • 1
    • 2
  • Jyoti Singh
    • 1
    • 3
  • Ajeet Kumar Srivastav
    • 1
    • 2
  • Divya Dubey
    • 1
    • 2
  • Ratan Singh Ray
    • 1
    • 3
  • Kailash Chand Gupta
    • 4
  1. 1.Photobiology Laboratory, Systems Toxicology and Health Risk Assessment GroupCSIR-Indian Institute of Toxicology ResearchLucknowIndia
  2. 2.Babu Banarasi Das UniversityLucknowIndia
  3. 3.Academy of Scientific and Innovative ResearchNew DelhiIndia
  4. 4.CSIR-Institute of Genomics and Integrative BiologyNew DelhiIndia

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