Phototoxicity of Hair Dyes: Challenge for Tropical Countries

  • Shruti Goyal
  • Ajeet Kumar Srivastav
  • Saroj K. Amar
  • Shikha Agnihotry
  • Ratan Singh Ray


In current scenario, utilization of hair dyes and personal care products (PCPs) has been increasing globally day to day. The US Aliment, Dye and Cosmetic Act require prior approbation of color additives, dyes, and cosmetics afore relinquishing product in market, but in India there was no guideline yet. According to survey more than one-third of women over age 18 and about 10% of men over age 40 utilize some type of hair dye coloring products for better physical appearance. Mostly, hair dye ingredient forms photoproduct after exposure of UV irradiation due to the presence of benzene nucleus or bulky structure with strong functional group. Photocytotoxicity results of hair dye ingredients in human keratinocyte cells illustrated the paramount reduction in cell survival. Photogenotoxic potential of hair dye was also reported in various past studies. Thus, study focused on hair dye which induced photogenotoxicity, photocytotoxicity, and apoptotic cell death through disturbing normal cell physiology. Therefore, joint exposure of sunlight and long-term use of hair dyes enhance oxidative stress in human skin which may lead to various skin diseases in human beings including mutation and various types of skin cancer.


Phototoxicity Hair dyes PCPs UV-R Sunlight 


  1. 1.
    CIR (2003) Cosmetic ingredient review: general informationGoogle Scholar
  2. 2.
    Foley P, Nixon R, Marks R, Frowen K, Thompson S (1993) The frequency of reactions to sunscreens: results of a longitude population based study on the regular use of sunscreen in Australia. Br J Dermatol 128:512CrossRefGoogle Scholar
  3. 3.
    de Groot AC (1990) Labelling cosmetics with their ingredients. Br Med J 300:1636–1638CrossRefGoogle Scholar
  4. 4.
    Fischer AA (1973) Cutaneous reactions to cosmetics, 2nd edn. Lea and Febiger, Philadelphia, pp 217–241Google Scholar
  5. 5.
    EPA (1982) Phenylenediamines: response to interagency testing committee. Fed Registry 47:979Google Scholar
  6. 6.
    de Groot AC, Frosch PJ (1997) Adverse reactions to fragrances: a clinical review. Contact Dermatitis 36:57–86CrossRefGoogle Scholar
  7. 7.
    IARC (1993) International Agency for the Research of Cancer, World Health Organisation. Occupational exposure of hairdressers and barbers and personal use of hair colorants. Some hair dyes, cosmetic colorants, industrial dyestuffs and aromatic amines, IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, vol 57. World Health Organisation, GenevaGoogle Scholar
  8. 8.
    Teramura AH (1983) Effects of ultraviolet-B radiation on the growth and yield of crop plants. Physiol Plant 58:415–427CrossRefGoogle Scholar
  9. 9.
    Nohynek GJ, Fautz R, Benech-Kieffer F, Toutain H (2004) Toxicity and human health risk of hair dyes. Food Chem Toxicol 42:517–543CrossRefGoogle Scholar
  10. 10.
    Goyal S, Amar SK, Dubey D, Pal M, Singh J, Verma A, Kushwaha HN, Ray RS (2015) Involvement of cathepsin B in mitochondrial apoptosis byp-phenylenediamine under ambient UV radiation. J Hazard Mater 300:415–425CrossRefGoogle Scholar
  11. 11.
    (1993) Issue 1 frequency of reactions to sunscreens: results of a longitudinal population based study on the regular use of sunscreen in Australia. Br J Dermatol 128:512–518Google Scholar
  12. 12.
    Förster T, Schwuger MJ (1990) Correlation between adsorption and the effects of surfactants and polymers on hair. Prog Colloid Polymer Sci 83:104–109CrossRefGoogle Scholar
  13. 13.
    Boveri T (2008) Concerning the origin of malignant tumors by Theodor Boveri (translated and annotated: Harris H). J Cell Sci 121(Supplement 1):1–84Google Scholar
  14. 14.
    SCCNFP (2003) Recommended strategy for testing hair dyes for their potential genotoxicity/mutagenicity/carcinogenicity. SCCNCP/0720/03, pp 1–10Google Scholar
  15. 15.
    Kirkland DJ, Honeycombe JR, Lawler SD (1981) Sister chromatid exchanges before and after hair dyeing. Mutat Res 90:279–286CrossRefGoogle Scholar
  16. 16.
    Yu H (2002) Environmental carcinogenic polycyclic aromatic hydrocarbons: photochemistry and phototoxicity. J Environ Sci Health C Environ Carcinog Ecotoxic Rev 20:149–183CrossRefGoogle Scholar
  17. 17.
    Rhen L (1895) Bladder tumours in fuchsin workers. Arch Klin Chirurgie 50:588–600Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Shruti Goyal
    • 1
  • Ajeet Kumar Srivastav
    • 1
    • 2
  • Saroj K. Amar
    • 3
  • Shikha Agnihotry
    • 4
  • Ratan Singh Ray
    • 1
  1. 1.Photobiology Laboratory, System Toxicology and Health Risk Assessment GroupCSIR-Indian Institute of Toxicology ResearchLucknowIndia
  2. 2.Babu Banarasi Das UniversityLucknowIndia
  3. 3.Department of Forensic Science, School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraIndia
  4. 4.Department of Biomedical-informaticsSanjay Gandhi Post Graduate InstituteLucknowIndia

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