Advertisement

Nano-based Delivery System for Nutraceuticals: The Potential Future

  • Manju Bernela
  • Pawan Kaur
  • Munish Ahuja
  • Rajesh Thakur
Chapter

Abstract

Nutraceuticals are food products that have health and medical benefits, hence promoting their use in prevention and treatment of diseases. Recently, nutraceuticals have come to limelight because of current lifestyle trends which lead to improper nutrition thereby creating a need for food supplements. Due to improper systemic delivery and poor oral bioavailability, potential use of nutraceuticals is limited. Most of the nutraceuticals show difficulty in adsorption through intestinal epithelium due to the presence of bilayer lipid membrane. Other factors such as low solubility or stability of nutraceuticals under harsh gastric conditions limit their beneficial use in health industry. Nanoencapsulation of nutraceuticals can improve their bioavailability thereby increasing health benefits. Recently there has been extensive research on encapsulation of nutraceuticals into biodegradable nanocarriers so as to increase their absorption and hence the therapeutic potential. Various materials have been used for formation of protective shell of encapsulates. The material should be food-grade and biodegradable and must be able to protect the internal phase from its surroundings. Of all the materials of choice, most frequently used are polysaccharides. Proteins and lipids are also promising candidates for appropriate encapsulation. The potential of nanotechnology to overcome the various limitations with the nutraceuticals based on the recent developments in this area are being reported.

References

  1. Altındal DC, Gümüşderelioglu M (2015) Melatonin releasing PLGA micro/nanoparticles and their effect on osteosarcoma cells. J Microencapsul 33(1):1–12Google Scholar
  2. Amin AR, Kucuk O, Khuri FR, Shin DM (2009) Perspectives for cancer prevention with natural compounds. J Clin Oncol 27:2712–2725CrossRefPubMedPubMedCentralGoogle Scholar
  3. Antônio E, Khalil NM, Mainardes RM (2016) Bovine serum albumin nanoparticles containing quercetin: characterization and antioxidant activity. J Nanosci Nanotechnol 16:1346–1353CrossRefPubMedGoogle Scholar
  4. Augustin MA, Hemar Y (2009) Nano- and micro-structured assemblies for encapsulation of food ingredients. Chem Soc Rev 38(4):902–912CrossRefPubMedGoogle Scholar
  5. Augustin MA, Sanguansri L (2012) Challenges in developing delivery systems for food additives, nutraceuticals, and dietary supplements. In: Garti N, McClements DJ (eds) Encapsulation technologies and delivery systems for food ingredients and nutraceuticals. Woodhead Publishing, Cambridge, UK, pp 19–48CrossRefGoogle Scholar
  6. Augustin MA, Abeywardena MY, Patten G, Head R et al (2011) Effects of microencapsulation on the gastrointestinal transit and tissue distribution of a bioactive mixture of fish oil, tributyrin and resveratrol. J Funct Foods 3:25–37CrossRefGoogle Scholar
  7. Bell LN (2001) Stability testing of nutraceuticals and functional foods. In: Wildman REC (ed) Handbook of nutraceuticals and functional foods. CRC Press, New York, pp 501–516Google Scholar
  8. Bernela M, Ahuja M, Thakur R (2016a) Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles. Carbohydr Polym 143:18–24CrossRefPubMedGoogle Scholar
  9. Bernela M, Ahuja M, Thakur R (2016b) Enhancement of anti-inflammatory activity of glycyrrhizic acid by encapsulation in chitosan-katira gum nanoparticles. Eur J Pharm Biopharm 105:141–147CrossRefPubMedGoogle Scholar
  10. Blazevic F, Milekic T, Romic MD, Juretic M et al (2016) Nanoparticle-mediated interplay of chitosan and melatonin for improved wound epithelialisation. Carbohydr Polym 146:445–454CrossRefPubMedGoogle Scholar
  11. Bourbon AI, Cerqueira MA, Vicente AA (2016) Encapsulation and controlled release of bioactive compounds in lactoferrin-glycomacropeptide nanohydrogels: curcumin and caffeine as model compounds. J Food Eng 180:110–119CrossRefGoogle Scholar
  12. Bouwmeester H, Dekkers S, Noordam MY, Hagens WI et al (1998) Nutraceuticals: poised for a healthy slice of the healthcare market? Nat Biotechnol 16:728–731CrossRefGoogle Scholar
  13. Chaiyasan W, Srinivas SP, Tiyaboonchai W (2016) Development and characterization of topical ophthalmic formulations containing lutein-loaded mucoadhesive nanoparticles. Int J Pharm Pharm Sci 8(3):261–266Google Scholar
  14. Das S, Chaudhury A (2010) Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS Pharm Sci Tech 12:62–76CrossRefGoogle Scholar
  15. Fakhoury IH, Saad WS, Gali-Muhtasib HU, Schneider-Stock R (2014) Thymoquinone nanoparticle formulation and in vitro efficacy in: materials for drug & gene delivery & cancer nanotech. Nanotech (2014) 2:367–370Google Scholar
  16. Fakoor Yazdan Abad M, Rajabzadeh G, Taghvaei Ganjali S, Tavakoli R (2016) Preparing allicin nanocapsules and determining the factors controlling their particle size through artificial intelligence. Int J Food Eng 12(3):257–264CrossRefGoogle Scholar
  17. Fathi M, Varshosaz J, Mohebbi M, Shahidi F (2013) Hesperetin-loaded solid lipid nanoparticles and nanostructure lipid carriers for food fortification: preparation, characterization, and modeling. Food Bioprocess Technol 6:1464–1475CrossRefGoogle Scholar
  18. Ferrari M (2005) Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 5:161–171CrossRefPubMedGoogle Scholar
  19. Frede K, Henze A, Khalil M, Baldermann S, Schweigert FJ, Rawel H (2014) Stability and cellular uptake of lutein-loaded emulsions. J Funct Foods 8:118–127CrossRefGoogle Scholar
  20. Grabley S, Thiericke R (1999) Bioactive agents from natural sources: trends in discovery and application. Adv Biochem Eng Biotechnol 64:101–154PubMedGoogle Scholar
  21. Guan X, Gao M, Xu H, Zhang C et al (2016) Quercetin-loaded poly (lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for the targeted treatment of liver cancer. Drug Deliv 23(9):3307–3318CrossRefPubMedGoogle Scholar
  22. Hong DY, Lee J-S, Lee HG (2015) Chitosan/poly-rmgamma-glutamic acid nanoparticles improve the solubility of lutein. Int J Biol Macromol 85:9–15CrossRefPubMedGoogle Scholar
  23. Huang Q, Yu H, Ru Q (2013) Bioavailability and delivery of nutraceuticals using nanotechnology. J Food Sci 75:50–57CrossRefGoogle Scholar
  24. Javeri I (2016) Application of “nano” nutraceuticals in medicine. In: Nutraceuticals: efficacy, safety and toxicity. Elsevier, Amsterdam, pp 189–192CrossRefGoogle Scholar
  25. Joung HJ, Choi M-J, Kim JT, Park SH, Park HJ, Shin GH (2016) Development of food-grade curcumin nanoemulsion and its potential application to food beverage system: antioxidant property and in vitro digestion. J Food Sci 81:745–753CrossRefGoogle Scholar
  26. Jourghanian P, Ghaffari S, Ardjmand M, Haghighat S, Mohammadnejad M (2016) Sustained release curcumin loaded solid lipid nanoparticles. Advan Pharma Bulletin 6:17–21CrossRefGoogle Scholar
  27. Kalra EK (2003) Nutraceutical – definition and introduction. AAPS Pharm Sci 5:27–28CrossRefGoogle Scholar
  28. Kim JH, Park EY, Ha HK, Jo CM et al (2016) Resveratrol-loaded nanoparticles induce antioxidant activity against oxidative stress. Asian-Aust J Anim Sci 29(2):288–298CrossRefGoogle Scholar
  29. Kosaraju SL (2005) Colon targeted delivery systems: review of polysaccharides for encapsulation and delivery. Crit Rev Food Sci Nutr 45(4):251–258CrossRefPubMedGoogle Scholar
  30. Krausz AE, Adler BL, Cabral V, Navati M et al (2015) Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomed: Nanotechnol Biol Med 11(1):195–206CrossRefGoogle Scholar
  31. Langer R (1990) New methods of drug delivery. Science 249:1527–1533CrossRefPubMedGoogle Scholar
  32. Lasic DD (1998) Novel applications of liposomes. Trends Biotechnol 16:307–321CrossRefPubMedGoogle Scholar
  33. Lasic DD, Martin FJ, Gabizon A, Huang SK, Papahadjopoulos D (1991) Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times. Biochim Biophys Acta 1070:187–192CrossRefPubMedGoogle Scholar
  34. Leach AR, Gillet VJ, Lewis RA, Taylor R (2010) Three-dimensional pharmacophore methods in drug discovery. J Med Chem 53:539–558CrossRefPubMedGoogle Scholar
  35. Li Y, Xiao H, McClements DJ (2012) Encapsulation and delivery of crystalline hydrophobic nutraceuticals using nanoemulsions: factors affecting polymethoxyflavone solubility. Food Biophys 7(4):341–353CrossRefPubMedPubMedCentralGoogle Scholar
  36. Li C, Zhang X, Huang X, Wang X, Liao G, Chen Z (2013) Preparation and characterization of flexible nanoliposomes loaded with daptomycin, a novel antibiotic for topical skin therapy. Int J Nanomedicine 8:1285–1292CrossRefPubMedPubMedCentralGoogle Scholar
  37. Livney YD (2008) Complexes and conjugates of biopolymers for delivery of bioactive ingredients via food. In: Delivery and controlled release of bioactives in foods and nutraceuticals, Woodhead Publishing series in Food Science, Technology and Nutrition. Woodhead, Cambridge, pp 234–242CrossRefGoogle Scholar
  38. Manea A-M, Vasile BS, Meghea A (2014) Antioxidant and antimicrobial activities of green tea extract loaded into nanostructured lipid carriers. C R Chim 17:331–341CrossRefGoogle Scholar
  39. McClements DJ, Decker EA, Park Y, Weiss J (2009) Structural design principles for delivery of bioactive components in nutraceuticals and functional foods. Crit Rev Food Sci Nutr 49(6):577–606CrossRefPubMedGoogle Scholar
  40. McClements DJ (2012a) Advances in fabrication of emulsions with enhanced functionality using structural design principles. Curr Opin Colloid Interface Sci 17(5):235–245CrossRefGoogle Scholar
  41. McClements DJ (2012b) Requirements for food ingredient and nutraceutical delivery systems. In: Encapsulation technologies and delivery systems for food ingredients and nutraceuticals. Woodhead Publishing, Cambridge, pp 3–18CrossRefGoogle Scholar
  42. McClements DJ (2012c) Nanoemulsions versus microemulsions: clarification of differences, similarities and terminology. Soft Matter 8(6):1719–1729CrossRefGoogle Scholar
  43. Molinski TF (1993) Developments in marine natural products, receptor-specific bioactive compounds. J Nat Prod 56:1–8CrossRefPubMedGoogle Scholar
  44. Momekova D, Rangelov S, Yanev S, Nikolova E et al (2007) Long-circulating, pH-sensitive liposomes sterically stabilized by copolymers bearing short blocks of lipid-mimetic units. Eur J Pharm Sci 32:308–317CrossRefPubMedGoogle Scholar
  45. Mozafari MR, Mortazavi SM (2005) Nanoliposomes: from fundamentals to recent developments. Trafford, Pub Ltd, Oxford. UKGoogle Scholar
  46. Mozafari MR, Flanagan J, Matia-Merino L et al (2006) Recent trends in the lipid-based nanoencapsulation of antioxidants and their role in foods. J Sci Food Agric 86(13):2038–2045CrossRefGoogle Scholar
  47. Mozafari MR, Pardakhty A, Azarmi S, Jazayeri JA et al (2009) Role of nanocarrier systems in cancer nanotherapy. J Liposome Res 19:310–321CrossRefPubMedGoogle Scholar
  48. Munin A, Edwards-Levy F (2011) Encapsulation of natural polyphenolic compounds: a review. Pharmaceutics 3:793–829CrossRefPubMedPubMedCentralGoogle Scholar
  49. Neves AR, Martins S, Segundo MA, Reis S (2016) Nanoscale delivery of resveratrol towards enhancement of supplements and nutraceuticals. Forum Nutr 8:131Google Scholar
  50. Pandey M, Verma RK, Saraf SA (2010) Nutraceuticals: new era of medicine and health. Asian J Pharm Clin Res 3:11–15Google Scholar
  51. Paul SD, Dewangan D (2016) Nanotechnology and nutraceuticals. Int J Nanomater Nanotechnol Nanomed 2(1):9–12Google Scholar
  52. Pradhan N, Singh S, Ojha N, Shrivastava A et al (2015) Facets of nanotechnology as seen in food processing, packaging, and preservation industry. Bio Med Res Int 2015:365672Google Scholar
  53. Puglia C, Offerta A, Tirendi GG, Tarico MS et al (2016) Design of solid lipid nanoparticles for caffeine topical administration. Drug Deliv 23(1):36–40CrossRefPubMedGoogle Scholar
  54. Qi LF, Xu ZR, Jiang X, Hu C, Zou X (2004) Preparation and antibacterial activity of chitosan nanoparticles. Carbohydr Res 339(16):2693–2700CrossRefPubMedGoogle Scholar
  55. Qian C, Decker EA, Xiao H, McClements DJ (2012) Nanoemulsion delivery systems: influence of carrier oil on beta-carotene bioaccessibility. Food Chem 135:1440–1447CrossRefPubMedGoogle Scholar
  56. Rani R, Dilbaghi N, Dhingra D, Kumar S (2015) Optimization and evaluation of bioactive drug-loaded polymeric nanoparticles for drug delivery. Int J Biol Macromol 78:173–179CrossRefPubMedGoogle Scholar
  57. Rapaka RS, Coates PM (2006) Dietary supplements and related products: a brief summary. Life Sci 78:2026–2032CrossRefPubMedGoogle Scholar
  58. Ravanfar R, Tamaddon AM, Niakousari M, Moein MR (2016) Preservation of anthocyanins in solid lipid nanoparticles: optimization of a microemulsion dilution method using the Plackett–Burman and Box–Behnken designs. Food Chem 199(15):573–580CrossRefPubMedGoogle Scholar
  59. Rein MJ, Renouf M, Cruz-Hernandez C, Actis-Goretta L, Thakkar SK, da Silva MP (2013) Bioavailability of bioactive food compounds: a challenging journey to bioefficacy. Br J Clin Pharmacol 75:588–602CrossRefPubMedPubMedCentralGoogle Scholar
  60. Renard D, Robert P, Lavenant L, Melcion D et al (2002) Biopolymeric colloidal carriers for encapsulation or controlled release applications. Int J Pharm 242(1–2):163–166CrossRefPubMedGoogle Scholar
  61. Riehemann K, Schneider SW, Luger TA, Godin B (2009) Nanomedicine-challenge and perspectives. Angew Chem Int Ed Eng 48:872–897CrossRefGoogle Scholar
  62. Scampicchio M, Ballabio D, Arecchi A, Cosio SM, Mannino S (2008) Amperometric electronic tongue for food analysis. Microchim Acta 163:11–21CrossRefGoogle Scholar
  63. Severino P, Andreani T, Macedo AS, Fangueiro JF et al (2011) Current state-of-art and new trends on lipid nanoparticles (SLN and NLC) for oral drug delivery. J Drug Deliv 12:1–10Google Scholar
  64. Shoji Y, Nakashima H (2004) Nutraceutics and delivery systems. J Drug Target 12:385–391CrossRefPubMedGoogle Scholar
  65. Singhal NK, Agarwal S, Bhatnagar P, Tiwari MN et al (2015) Mechanism of nanotization-mediated improvement in the efficacy of caffeine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism. J Biomed Nanotechnol 11(12):2211–2222CrossRefPubMedGoogle Scholar
  66. Sinha VR, Kumria R (2001) Polysaccharides in colon-specific drug delivery. Int J Pharm 224:19–38CrossRefPubMedGoogle Scholar
  67. Sivakumar M, Tang SY, Tan KW (2014) Cavitation technology – a greener processing technique for the generation of pharmaceutical nanoemulsions. Ultrason Sonochem 21:2069–2083CrossRefPubMedGoogle Scholar
  68. Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma MJ (2005) Nanoemulsions. Curr Opin Colloid Interface Sci 10(3–4):102–110CrossRefGoogle Scholar
  69. Sondi I, Salopek-Sondi B (2004) Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gramnegative bacteria. J Colloid Interface Sci 275(1):177–182CrossRefPubMedPubMedCentralGoogle Scholar
  70. Sun Y, Xia Z, Zheng J, Qiu P, Zhang L, McClements DJ, Xiao H (2015) Nanoemulsion-based delivery systems for nutraceuticals: influence of carrier oil type on bioavailability of pterostilbene. J Funct Foods 13:61–70CrossRefGoogle Scholar
  71. Tang S, Gao D, Zhao T, Zhou J, Zhao X (2013) An evaluation of the anti-tumor efficacy of oleanolic acid-loaded PEGylated liposomes. Nanotechnology 24:235102CrossRefPubMedGoogle Scholar
  72. Taylor TM, Davidson PM, Bruce BD, Weiss J (2005) Liposomal nanocapsules in food science and agriculture. Crit Rev Food Sci Nutr 45(7–8):587–605CrossRefPubMedGoogle Scholar
  73. Tiede K, Boxall ABA, Tear SP, Lewis J, David H, Hassellov M (2008) Detection and characterization of engineered nanoparticles in food and the environment. Food Addit Contam Part A-Chem Anal Control Expo Risk Assess 25(7):795–821CrossRefPubMedGoogle Scholar
  74. Ting YW, Jiang Y, Ho CT, Huang QR (2014) Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals. J Funct Foods 7:112–128CrossRefGoogle Scholar
  75. Trottier G, Boström PJ, Lawrentschuk N, Fleshner NE (2010) Nutraceuticals and prostate cancer prevention. A Curr Rev Nat Rev Urol 7:21–30CrossRefGoogle Scholar
  76. Vidal SL, Rojas C, Padin RB, Rivera MP, Haensgen A, Gonzalez M, Rodriguez-Llamazares S (2016) Synthesis and characterization of polyhydroxybutyrate-cohydroxyvalerate nanoparticles for encapsulation of quercetin. J Bioact Compat Polym 31(5):1–14Google Scholar
  77. Vijayakumar MR, Kumari L, Patel KK, Vuddanda PR et al (2016) Intravenous administration of trans-resveratrol-loaded TPGS-coated solid lipid nanoparticles for prolonged systemic circulation, passive brain targeting and improved in vitro cytotoxicity against C6 glioma cell lines. RSC Adv 6:50336–50348CrossRefGoogle Scholar
  78. Wagner V, Dullaart A, Bock AK, Zweck A (2006) The emerging nanomedicine landscape. Nat Biotechnol 24:1211–1217CrossRefPubMedGoogle Scholar
  79. Weber S, Zimmer A, Pardeike J (2014) Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for pulmonary application: a review of the state of the art. Eur J Pharma Biopharm 86:7–22CrossRefGoogle Scholar
  80. Yu H, Huang Q (2013) Bioavailability and delivery of nutraceuticals and functional foods using nanotechnology. In: Di B, Bagchi M, Moriyama H, Shahidi F (eds) Bio-nanotechnology: a revolution in food, biomedical and health sciences, 1st edn. Blackwell Publishing Ltd., Oxford. https://doi.org/10.1002/9781118451915. ch35CrossRefGoogle Scholar
  81. Zheng J, Li Y, Song M, Fang X et al (2014) Improving intracellular uptake of 5-demethyltangeretin by food grade nanoemulsions. Food Res Int 62:98–103CrossRefGoogle Scholar
  82. Zhu Y, Peng W, Zhang J, Wang M et al (2014) Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: preparation, in vitro and in vivo evaluation. J Funct Foods 8:358–366CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Manju Bernela
    • 1
  • Pawan Kaur
    • 2
  • Munish Ahuja
    • 1
  • Rajesh Thakur
    • 1
  1. 1.Department of Bio & NanotechnologyGuru Jambheshwar University of Science and TechnologyHisarIndia
  2. 2.Department of BiotechnologyChaudhary Devi Lal UniversitySirsaIndia

Personalised recommendations