Silencing Human VCAM 1 Gene
One of the key steps in the initiation of atherosclerosis is the adhesion of leukocytes on the activated vascular endothelial cells and their relocation into the vessel wall. This occurs because of the upregulation of the adhesion/attachment particles like vascular cell adhesion molecule-1 (VCAM-1) on the activated vascular endothelial cells and an expanded expression in the vascular mass of chemotactic elements to the monocytes. Similar mechanisms in reverse underlie cancer cell metastasis and other inflammatory disease processes. So interfering with VCAM1 expression could be a valuable approach to prevention and cure of diseases as diverse as atherosclerosis, cancer, graft rejection, etc. The beginnings of RNA interference (RNAi) as a gene knockdown technique symbolize an electrifying improvement in the field of small-molecule nucleic acid-based therapeutics. Present review is focused on the gene VCAM1, as a target for development of potential new therapies.
This work was supported by Department of Biotechnology, New Delhi [Project No. BT/PR10694/AGR/36/587/2008], University Grants Commission, New Delhi [F.14-2(SC)/2009 (SA-III)] and the grant from DBT Interdisciplinary Life Sciences Programme for Advance Research and Education [DBT-IPLS Project No BT/PR4548/INF/22/146/2012]; Punjabi University, Patiala.
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