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New Approaches for Improvement of Diva Vaccines and Their Companion Diagnostic Tests for Foot-and-Mouth Disease and Bluetongue Disease

  • P. Minakshi
  • Anuj Tiwari
  • Beenu Jain
  • Gaya Prasad
Chapter

Abstract

Vaccination is one of the effective ways to control disease outbreak and virus circulation both in endemic and disease-free countries. Endemic countries follow vaccination annually as a prophylactic measure subsequently increasing antibody titre of animals. In disease-free countries, emergency vaccination with high PD50 vaccine is done. In both the cases vaccine capable of eliciting long-lasting immune response followed by a robust companion Differentiating Infected from Vaccinated Animals (DIVA) test is required.

In today’s world, increased globalization and environmental changes make the animals more susceptible to diseases. Livestock viral disease is one of the groups of these diseases which can cause huge economic losses in both endemic and disease-free countries. To control these diseases in the developing countries, long-term control measures need to be applied. Developed countries need to keep a check on the possible incursion of the virus along with a proper backup of emergency vaccines. Due to ethical reasons, slaughtering of animals to control epidemics is unacceptable. Therefore, vaccination to control the spread of virus plays an important role in both developed and developing countries.

In endemic countries vaccination can be used as a prophylactic measure to increase the antibody titre of susceptible animals subsequently preventing disease outbreaks. In disease-free countries in case of outbreak situation, emergency vaccination followed by serosurveillance is done to declare “freedom from disease”. Vaccination can reduce the incidence of the disease; therefore, reliance on observation of clinical signs may not be a possible method of surveillance to demonstrate freedom from infection. Hence, it is paramount to have a negative marker vaccine which induces antibody response against important epitopes and negatively marked with other epitopes. These negatively marked epitopes in vaccines can be used to detect infection in vaccinated animals. This strategy to detect infection is called “DIVA” that is Differentiating Infected from Vaccinated Animals. In the following part, the DIVA vaccines and their companion diagnostic tests for two economically important diseases bluetongue and foot-and-mouth disease (FMD) are discussed.

References

  1. Alexandersen S, Zhang Z, Reid SM et al (2002) Quantities of infectious virus and viral RNA recovered from sheep and cattle experimentally infected with foot-and-mouth disease virus O UK 2001. J Gen Virol 83:1915–1923CrossRefPubMedGoogle Scholar
  2. Athmaram TN, Bali G, Kahng GG, Dwarakanath S (2007) Heterologous expression of bluetongue VP2 viral protein fragment in Pichia pastoris. Virus Genes 35(2):265–271CrossRefPubMedGoogle Scholar
  3. Bachrach HL, Moore DM, McKercher PD, Polatnick J (1975) Immune and antibody responses to an isolated capsid protein of foot-and-mouth disease virus. J Immunol (Baltimore, Md.: 1950) 115:1636–1641Google Scholar
  4. Balasuriya UB, Shi PY, Wong SJ, Demarest VL, Gardner IA, Hullinger, PJ, Ferraro GL, Boone JD, De Cino CL, Glaser AL, Renshaw RW, Ledizet M, Koski RA, MacLachlan NJ (2006) Detection of antibodies to West Nile virus in equine sera using microsphere immunoassay. J Vet Diagn Invest: official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 18, 392–395CrossRefPubMedGoogle Scholar
  5. Barnett PV, Cox SJ (1999) The role of small ruminants in the epidemiology and transmission of foot-and-mouth disease. Vet J 158:6–13CrossRefPubMedGoogle Scholar
  6. Barros SC, Cruz B, Luis TM et al (2009) A DIVA system based on the detection of antibodies to non-structural protein 3 (NS3) of blue tongue virus. Vet Microbiol 137:252–259CrossRefPubMedGoogle Scholar
  7. Batten CA, Maan S, Shaw AE et al (2008) A European field strain of bluetongue virus derived from two parenteral vaccine strains by genome segment reassortment. Vir Res 137(1):56–63CrossRefGoogle Scholar
  8. Belsham GJ (1993) Distinctive features of foot-and-mouth disease virus, a member of the picornavirus family; aspects of virus protein synthesis, protein processing and structure. Prog Biophys Mol Biol 60:241–260CrossRefPubMedGoogle Scholar
  9. Belyaev AS, Roy P (1993) Development of baculovirus triple and quadruple expression vectors: co-expression of three or four bluetongue virus proteins and the synthesis of bluetongue virus-like particles in insect cells. Nuc Acids Res 21:1219–1223CrossRefGoogle Scholar
  10. Bhanuprakash V, Indrani BK, Hosamani M et al (2009) Bluetongue vaccines: the past, present and future. Exp Rev Vacc 8:191–204CrossRefGoogle Scholar
  11. Bittle JL, Houghten RA, Alexander H, Shinnick TM, Sutcliffe JG, Lerner RA, Rowlands DJ, Brown F (1982) Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. Nature 298:30–33CrossRefPubMedGoogle Scholar
  12. Boone JD, Balasuriya UB, Karaca K, Audonnet JC et al (2007) Recombinant canary-pox virus vaccine co-expressing genes encoding the VP2 and VP5 outer capsid proteins of bluetongue virus induces high level protection in sheep. Vaccine 25(4):672–678CrossRefPubMedGoogle Scholar
  13. Brocchi E, Bergmann IE, Dekker A, Paton DJ et al (2006) Comparative evaluation of six ELISAs for the detection of antibodies to the non-structural proteins of foot-and-mouth disease virus. Vaccine 24:6966–6979CrossRefPubMedGoogle Scholar
  14. Bruderer U, Swam H, Haas B, Visser N, Brocchi E, Grazioli S, Esterhuysen JJ, Vosloo W, Forsyth M, Aggarwal N, Cox S, Armstrong R, Anderson J (2004) Differentiating infection from vaccination in foot-andmouth-disease: evaluation of an ELISA based on recombinant 3ABC. Vet Microbiol 101:187–197CrossRefPubMedGoogle Scholar
  15. Callens M, de Clercq K, Gruia M, Danes M (1998) Detection of foot-and-mouth disease by reverse transcription polymerase chain reaction and virus isolation in contact sheep without clinical signs of foot-and-mouth disease. Vet Q 20(Suppl 2):37–40CrossRefPubMedGoogle Scholar
  16. Cao Y, Lu Z, Sun J, Bai X, Sun P, Bao H, Chen Y, Guo J, Li D, Liu X, Liu Z (2009) Synthesis of empty capsid-like particles of Asia I foot-and-mouth disease virus in insect cells and their immunogenicity in guinea pigs. Vet Microbiol 137:10–17CrossRefPubMedGoogle Scholar
  17. Caporale V, Giovannini A (2010) Bluetongue control strategy, including recourse to vaccine: a critical review. Rev Sci Tech Off Int des Epizoot 29:573–591CrossRefGoogle Scholar
  18. Carpi G, Holmes EC, Kitchen A (2010) The evolutionary dynamics of bluetongue virus. J Mol Evol 70:583–592CrossRefPubMedGoogle Scholar
  19. Celma CC, Boyce M, van Rijn PA et al (2013) Rapid generation of replication-deficient monovalent and multivalent vaccines for bluetongue virus: protection against virulent virus challenge in cattle and sheep. J Virol 87(17):9856–9864CrossRefPubMedPubMedCentralGoogle Scholar
  20. Chaignat V, Worwa G, Scherrer N, Hilbe M et al (2009) Toggenburg orbivirus, a new bluetongue virus: initial detection, first observations in field and experimental infection of goats and sheep. Vet Microbiol 138:11–19CrossRefPubMedGoogle Scholar
  21. Chung WB, Sorensen KJ, Liao PC, Yang PC, Jong MH (2002) Differentiation of foot-and-mouth disease virus-infected from vaccinated pigs by enzyme-linked immunosorbent assay using nonstructural protein 3AB as the antigen and application to an eradication program. J Clin Microbiol 40:2843–2848CrossRefPubMedPubMedCentralGoogle Scholar
  22. Clavijo A, Hole K, Li M, Collignon B (2006) Simultaneous detection of antibodies to foot-and-mouth disease non-structural proteins 3ABC, 3D, 3A and 3B by a multiplexed Luminex assay to differentiate infected from vaccinated cattle. Vaccine 24:1693–1704CrossRefPubMedGoogle Scholar
  23. Cowley JA, Gorman BM (1989) Cross-neutralization of genetic reassortants of bluetongue virus serotypes 20 and 21. Vet Microbiol 19:37–51CrossRefPubMedGoogle Scholar
  24. Cox E, Verdonck F, Vanrompay D, Goddeeris B (2006) Adjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa. Vet Res 37:511–539CrossRefPubMedGoogle Scholar
  25. De Diego M, Brocchi E, Mackay D, De Simone F (1997) The non-structural polyprotein 3ABC of foot-andmouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle. Arch Virol 142:2021–2033CrossRefPubMedGoogle Scholar
  26. DiMarchi R, Brooke G, Gale C, Cracknell V, Doel T, Mowat N (1986) Protection of cattle against foot-andmouth disease by a synthetic peptide. Science 232:639–641CrossRefPubMedGoogle Scholar
  27. Doel TR (1999) Optimisation of the immune response to foot-and-mouth disease vaccines. Vaccine 17:1767–1771CrossRefPubMedGoogle Scholar
  28. Du J, Guo X, Gao S, Luo J, Gong X, Hao C, Yang B, Lin T, Shao J, Cong G, Chang H (2014) Induction of protection against foot-and-mouth disease virus in cell culture and transgenic suckling mice by miRNA targeting integrin αv receptor. J Biotechnol 187:154–161CrossRefPubMedGoogle Scholar
  29. Elia G, Savini G, Decaro N, Martella V et al (2008) Use of real-time RT-PCR as a rapid molecular approach for differentiation of field and vaccine strains of bluetongue virus serotypes 2 and 9. Mol Cell Probes 22(1):38–46CrossRefPubMedGoogle Scholar
  30. Feenstra F, Pap JS, van Rijn PA (2014) Application of blue tongue Disabled Infectious Single Animal (DISA) vaccine for different serotypes by VP2 exchange or incorporation of chimeric VP2. Vaccine 33(6):812–818CrossRefPubMedGoogle Scholar
  31. Feng Q, Yu H, Liu Y, He C, Hu J, Sang H, Ding N, Ding M, Fung YW, Lau LT, Yu AC, Chen J (2004) Genome comparison of a novel foot-and-mouth disease virus with other FMDV strains. Biochem Biophys Res Commun 323:254–263CrossRefPubMedGoogle Scholar
  32. Fowler V, Robinson L, Bankowski B, Cox S, Parida S, Lawlor C, Gibson D, O’brien F, Ellefsen B, Hannaman D, Takamatsu HH, Barnett PV (2012) A DNA vaccination regime including protein boost and electroporation protects cattle against foot-and-mouth disease. Antiviral Res 94:25–34CrossRefPubMedGoogle Scholar
  33. Francis MJ, Hastings GZ, Brown F, McDermed J, Lu YA, Tam JP (1991) Immunological evaluation of the multiple antigen peptide (MAP) system using the major immunogenic site of foot-and-mouth disease virus. Immunology 73:249–254PubMedPubMedCentralGoogle Scholar
  34. French TJ, Marshall JJ, Roy P (1990) Assembly of double-shelled, virus like particles of bluetongue virus by the simultaneous expression of four structural proteins. J Virol 64(12):5695–5700PubMedPubMedCentralGoogle Scholar
  35. Fu Y, Cao Y, Sun P, Bao H, Bai X, Li P, Li D, Lu Z, Liu Z (2011 January) Development of a dot immunoblot method for differentiation of animals infected with foot-and-mouth disease virus from vaccinated animals using non-structural proteins expressed prokaryotically. J Virol Methods 171(1):234–240CrossRefPubMedGoogle Scholar
  36. Golde WT, Pacheco JM, Duque H et al (2005) Vaccination against foot-and-mouth disease virus confers complete clinical protection in 7 days and partial protection in 4 days: use in emergency outbreak response. Vaccine 23:5775–5782CrossRefPubMedGoogle Scholar
  37. Hema M, Nagendrakumar SB, Yamini R, Chandran D, Rajendra L, Thiagarajan D, Parida S, Paton DJ, Srinivasan VA (2007) Chimeric tymovirus-like particles displaying foot-and-mouth disease virus non-structural protein epitopes and its use for detection of FMDV-NSP antibodies. Vaccine 25:4784–4794CrossRefPubMedGoogle Scholar
  38. Hofmann MA, Renzullo S, Mader M et al (2008) Genetic characterization of Toggenburg orbivirus, a new bluetongue virus from goats, Switzerland. Emerg Infect Dis 14:1855–1861CrossRefPubMedPubMedCentralGoogle Scholar
  39. Inoue T, Parida S, Paton DJ, Linchongsubongkoch W, Mackay D, Oh Y, Aunpomma D, Gubbins S, Saeki T (2006) Development and evaluation of an indirect enzyme-linked immunosorbent assay for detection of foot-and-mouth disease virus nonstructural protein antibody using a chemically synthesized 2B peptide as antigen. J Vet Diagn Invest 18:545–552CrossRefPubMedGoogle Scholar
  40. Kar AK, Bhattacharya B, Roy P (2007) Bluetongue virus RNA binding protein NS2 is a modulator of viral replication and assembly. BMC Mol Bio 8:4CrossRefGoogle Scholar
  41. Kellar KL, Oliver KG (2004) Multiplexed microsphere assays for protein and DNA binding reactions. Methods Cell Biol 75:409–429CrossRefPubMedGoogle Scholar
  42. Kit M, Kit S, Little SP, Di Marchi RD, Gale C (1991) Bovine herpesvirus-1 (infectious bovine rhinotracheitis virus)-based viral vector which expresses foot-and-mouth disease epitopes. Vaccine 9:564–572CrossRefPubMedGoogle Scholar
  43. Kitson JD, Burke KL, Pullen LA, Belsham GJ, Almond JW (1991) Chimeric polioviruses that include sequences derived from two independent antigenic sites of foot-and-mouth disease virus (FMDV) induce neutralizing antibodies against FMDV in guinea pigs. J Virol 65:3068–3075PubMedPubMedCentralGoogle Scholar
  44. Khan IH, Kendall LV, Ziman M, Wong S, Mendoza S, Fahey J, Griffey SM, Barthold SW, Luciw PA (2005) Simultaneous serodetection of 10 highly prevalent mouse infectious pathogens in a single reaction by multiplex analysis. Clin Diagn Lab Immunol 12:513–519PubMedPubMedCentralGoogle Scholar
  45. Kleid DG, Yansura D, Small B, Dowbenko D, Moore DM, Grubman MJ, McKercher PD, Morgan DO, Robertson BH, Bachrach HL (1981) Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine. Science 214:1125–1129CrossRefPubMedGoogle Scholar
  46. Komatsu N, Shichijo S, Nakagawa M, Itoh K (2004) New multiplexed flow cytometric assay to measure antipeptide antibody: a novel tool for monitoring immune responses to peptides used for immunization. Scand J Clin Lab Invest 64:535–545CrossRefPubMedGoogle Scholar
  47. Li J, Liu Y, Liu X, Shang Y, Liu J, An F, Yin H (2008a) [Screening and stability of Madin-Darby bovine kidney cell strain co-expressing the capsid precursor protein P1-2A gene and the protease 3C gene of foot-andmouth disease virus]. Wei sheng wu xue bao = Acta Microbiol Sin 48:1520–1525Google Scholar
  48. Li Z, Yi Y, Yin X, Zhang Z, Liu J (2008b) Expression of foot-and-mouth disease virus capsid proteins in silkworm-baculovirus expression system and its utilization as a subunit vaccine. PLoS One 3:e2273CrossRefPubMedPubMedCentralGoogle Scholar
  49. Li YG, Tian FL, Gao FS et al (2007) Immune responses generated by Lactobacillus as a carrier in DNA immunization against foot-and-mouth disease virus. Vaccine 25:902–911CrossRefPubMedGoogle Scholar
  50. Li Z, Yin X, Yi Y, Li X, Li B, Lan X, Zhang Z, Liu J (2011) FMD subunit vaccine produced using a silkwormbaculovirus expression system: protective efficacy against two type Asia1 isolates in cattle. Vet Microbiol 149:99–103CrossRefPubMedGoogle Scholar
  51. Lobato ZI, Coupar BE, Gray CP et al (1997) Antibody responses and protective immunity to recombinant vaccinia virus-expressed bluetongue virus antigens. Vet Immunol Immunopathol 59(3–4):293–309CrossRefPubMedGoogle Scholar
  52. Lombard M, Pastoret PP, Moulin AM (2007) A brief history of vaccines and vaccination. Rev Sci Tech 26:29–48CrossRefPubMedGoogle Scholar
  53. Maan S, Maan NS, Nomikou K, Batten C et al (2011) Novel bluetongue virus serotype from Kuwait. Emergy Infect Dis 17:886–889CrossRefGoogle Scholar
  54. Mahajan S, Mohapatra JK, Pandey LK, Sharma GK, Pattnaik B (2013) Truncated recombinant nonstructural protein 2C-based indirect ELISA for FMD sero-surveillance. J Virol Methods 193:405–414CrossRefPubMedGoogle Scholar
  55. Malirat V, Neitzert E, Bergmann IE, Maradei E, Beck E (1998) Detection of cattle exposed to foot-and-mouth disease virus by means of an indirect ELISA test using bioengineered nonstructural polyprotein 3ABC. Vet Q 20(Suppl 2):S24–S26CrossRefPubMedGoogle Scholar
  56. Matsuo E, Celma CC, Boyce M, Viarouge C et al (2011) Generation of replication-defective virus-based vaccines that confer full protection in sheep against virulent bluetongue virus challenge. J Virol 85:10213–10221CrossRefPubMedPubMedCentralGoogle Scholar
  57. McBride N, Shichijo S, Nakagawa M, Itoh K (2004) New multiplexed flow cytometric assay to measure antipeptide antibody: a novel tool for monitoring immune responses to peptides used for immunization. Scand J Clin Lab Invest 64:535–545Google Scholar
  58. McBride MT, Gammon S, Pitesky M, O’Brien TW, Smith T, Aldrich J, Langlois RG, Colston B, Venkateswaran KS (2003a) Multiplexed liquid arrays for simultaneous detection of simulants of biological warfare agents. Anal Chem 75:1924–1930CrossRefPubMedGoogle Scholar
  59. McBride MT, Masquelier D, Hindson BJ, Makarewicz AJ, Brown S, Burris K, Metz T, Langlois RG, Tsang KW, Bryan R, Anderson DA, Venkateswaran KS, Milanovich FP, Colston BW Jr (2003b) Autonomous detection of aerosolized Bacillus anthracis and Yersinia pestis. Anal Chem 75:5293–5299CrossRefPubMedGoogle Scholar
  60. Mertens PPC, Pedley S, Cowley J et al (1989) Analysis of the roles of bluetongue virus outer capsid proteins VP2 and VP5 in determination of virus serotype. Virology 170:561–565CrossRefPubMedGoogle Scholar
  61. Mohapatra AK, Mohapatra JK, Pandey LK, Sanyal A, Pattnaik B (2014) Diagnostic potential of recombinant nonstructural protein 3B to detect antibodies induced by foot-and-mouth disease virus infection in bovines. Arch Virol 159:2359–2369CrossRefPubMedGoogle Scholar
  62. Moraes MP, Mayr GA, Mason PW, Grubman MJ (2002) Early protection against homologous challenge after a single dose of replication-defective human adenovirus type 5 expressing capsid proteins of foot-and-mouth disease virus (FMDV) strain A24. Vaccine 20:1631–1639CrossRefPubMedGoogle Scholar
  63. Mulcahy G, Reid E, Dimarchi RD, Gale C, Doel TR (1992) Maturation of functional antibody affinity in animals immunised with synthetic foot-and-mouth disease virus. Res Vet Sci 52:133–140CrossRefPubMedGoogle Scholar
  64. Nargi F, Kramer E, Mezencio J, Zamparo J, Whetstone C, Van Regenmortel MH, Briand JP, Muller S, Brown F (1999) Protection of swine from foot-and-mouth disease with one dose of an all-D retro peptide. Vaccine 17:2888–2893CrossRefPubMedGoogle Scholar
  65. Nuttall PA, Jacobs SC, Jones LD, Carey D, Moss SR (1992) Enhanced neurovirulence of tick-borne orbiviruses resulting from genetic modulation. Virology 187:407–412CrossRefPubMedGoogle Scholar
  66. O’Hara RS, Meyer AJ, Burroughs JN et al (1998) Development of a mouse model system and identification of individual genome segments of African horse sickness virus, serotypes 3 and 8 involved in determination of virulence. Arch Virol 14:259–279Google Scholar
  67. Oberst RD, Stott JL, Blanchard-Channell M, Osburn BI (1987) Genetic reassortment of bluetongue virus serotype 11 strains in the bovine. Vet Microbiol 15:11–18CrossRefPubMedGoogle Scholar
  68. Oem JK, Chang BS, Joo HD, Yang MY, Kim GJ, Park JY, Ko YJ, Kim YJ, Park JH, Joo YS (2007) Development of an epitope-blocking-enzyme-linked immunosorbent assay to differentiate between animals infected with and vaccinated against foot-and-mouth disease virus. J Virol Methods 142:174–181CrossRefPubMedGoogle Scholar
  69. Pacheco JM, Brum MC, Moraes MP, Golde WT, Grubman MJ (2005) Rapid protection of cattle from direct challenge with foot-and-mouth disease virus (FMDV) by a single inoculation with an adenovirus-vectored FMDV subunit vaccine. Virology 337:205–209CrossRefPubMedGoogle Scholar
  70. Parida S, Cox SJ, Reid SM, Hamblin P, Barnett PV, Inoue T, Anderson J, Paton DJ (2005) The application of new techniques to the improved detection of persistently infected cattle after vaccination and contact exposure to foot-and-mouth disease. Vaccine 23:5186–5195CrossRefPubMedGoogle Scholar
  71. Paton DJ, de Clercq K, Greiner M, Dekker A et al (2006) Application of non-structural protein antibody tests in substantiating freedom from foot-and-mouth disease virus infection after emergency vaccination of cattle. Vaccine 24:6503–6512CrossRefPubMedGoogle Scholar
  72. Pearson LD, Roy P (1993) Genetically engineered multi-component virus-like particles as veterinary vaccines. Immunol Cell Biol 71(5):381–389CrossRefPubMedGoogle Scholar
  73. Perez-Martin E, Diaz-San Segundo F, Weiss M, Sturza DF, Dias CC, Ramirez-Medina E, Grubman MJ, de Los Santos T (2014) Type III interferon protects swine against foot-and-mouth disease. J Interf Cytokine Res: the official journal of the international society for interferon and cytokine researchGoogle Scholar
  74. Perkins J, Clavijo A, Hindson BJ et al (2006) Multiplexed detection of antibodies to nonstructural proteins of foot-and-mouth disease virus. Anal Chem 78:5462–5468CrossRefPubMedGoogle Scholar
  75. Perkins J, Parida S, Clavijo A (2007) Use of a standardized bovine serum panel to evaluate a multiplexed nonstructural protein antibody assay for serological surveillance of foot-and-mouth disease. Clin Vaccine Immunol 14:1472–1482CrossRefPubMedPubMedCentralGoogle Scholar
  76. Persson K, Nordengrahn A, Decker C, Merza M. (2004, October 11–15) The development of an indirect ELISA for the detection of antibodies to the non-structural protein 3ABC of the foot-and-mouth disease virus; the use of a polyclonal conjugate that allows a multi-species detection of antibodies. Report of the Session of the Research Group of the Standing Technical Committee of the European Commission for the Control of Foot-and- Mouth Disease. FAO, Rome, Chania, Crete, Greece, p. 479–80.Google Scholar
  77. Pfaff E, Mussgay M, Bohm HO, Schulz GE, Schaller H (1982) Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus. EMBO J 1:869–874PubMedPubMedCentralCrossRefGoogle Scholar
  78. Porta C, Kotecha A, Burman A, Jackson T, Ren J, Loureiro S, Jones IM, Fry EE, Stuart DI, Charleston B (2013) Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen. PLoS pathogens 9:e1003255CrossRefPubMedPubMedCentralGoogle Scholar
  79. Ren X, Xue F, Zhu Y, Tong G, Wang Y, Feng J, Zu L, Li J, Shi H, Gao Y, (2009). [Construction and identification of recombinant BHV-1 expressing foot and mouth disease virus VP1 gene]. Wei sheng wu xue bao = Acta Microbiol Sin 49:677–682Google Scholar
  80. Rodriguez LL, Gay CG (2011) Development of vaccines toward the global control and eradication of foot-and-mouth disease. Expert Rev Vaccines 10:377–387CrossRefPubMedGoogle Scholar
  81. Rodriguez LL, Grubman MJ (2009) Foot and mouth disease virus vaccines. Vaccine 27(Suppl 4):D90–D94CrossRefPubMedGoogle Scholar
  82. Roy P (2008) Functional mapping of bluetongue virus proteins and their interactions with host proteins during virus replication. Cell Biochem Biophy 50:143–157CrossRefGoogle Scholar
  83. Roy P, Noad R (2006) Bluetongue virus assembly and morphogenesis. In: Roy P (ed) Reoviruses: entry, assembly and morphogenesis, current topics in microbiology and immunology. Springer, Berlin, pp 87–116CrossRefGoogle Scholar
  84. Roy P, Bishop DH, Le Blois H, Erasmus BJ (1994) Long-lasting protection of sheep against bluetongue challenge after vaccination with virus-like particles: evidence for homologous and partial heterologous protection. Vaccine 12(9):805–811CrossRefPubMedGoogle Scholar
  85. Roy P, Boyce M, Noad R (2009) Prospects for improved bluetongue vaccines. Nat Rev Microbiol 7:120–128CrossRefPubMedGoogle Scholar
  86. Salt JS (1993) The carrier state in foot and mouth disease-an immunological review. Br Vet J 149:207–223CrossRefPubMedGoogle Scholar
  87. Samal SK, El-Hussein A, Holbrook FR, Beaty BJ, Famig RF (1987) Mixed infection of Culicoides variipennis with bluetongue virus serotypes 10 and 17: evidence for high frequency reassortment in the vector. J Gen Virol 68:2319–2329CrossRefPubMedGoogle Scholar
  88. Savini G, MacLachlan NJ, Sanchez-Vizcaino JM, Zientar S (2008) Vaccines against blue tongue in Europe. Comp Immunol Microbiol Infect Dis 31(2–3):101–120CrossRefPubMedGoogle Scholar
  89. Savini G, Hamers C, Conte A, Migliaccio P et al (2009) Assessment of efficacy of a bivalent BTV-2 and BTV-4 inactivated vaccine by vaccination and challenge in cattle. Vet Microbiol 133:1–8CrossRefPubMedGoogle Scholar
  90. Sharma GK, Mohapatra JK, Pandey LK, Mahajan S, Mathapati BS, Sanyal A, Pattnaik B (2012) Immunodiagnosis of foot-and-mouth disease using mutated recombinant 3ABC polyprotein in a competitive ELISA. J Virol Methods 185:52–60CrossRefPubMedGoogle Scholar
  91. Schwartz-Cornil I, Mertens PPC, Contreras V et al (2008) Bluetongue virus: virology, pathogenesis and immunity. Vet Res 39:46CrossRefPubMedGoogle Scholar
  92. Shen F, Chen PD, Walfield AM, Ye J, House J, Brown F, Wang CY (1999) Differentiation of convalescent animals from those vaccinated against foot-and-mouth disease by a peptide ELISA. Vaccine 17:3039–3049CrossRefPubMedGoogle Scholar
  93. Sorensen KJ, Madsen KG, Madsen ES, Salt JS, Nqindi J, Mackay DK (1998) Differentiation of infection from vaccination in foot-and-mouth disease by the detection of antibodies to the non-structural proteins 3D, 3AB and 3ABC in ELISA using antigens expressed in baculovirus. Arch Virol 143:1461–1476CrossRefPubMedGoogle Scholar
  94. Srisombundit V, Tungthumniyom N, Linchongsubongkoch W, Lekcharoensuk C, Sariya L, Ramasoota P, Lekcharoensuk P (2013) Development of an inactivated 3C(pro)-3ABC (mu3ABC) ELISA to differentiate cattle infected with foot and mouth disease virus from vaccinated cattle. J Virol Methods 188(1–2):161–167CrossRefPubMedGoogle Scholar
  95. Strohmaier K, Franze R, Adam KH (1982) Location and characterization of the antigenic portion of the FMDV immunizing protein. J Gen Virol 59:295–306CrossRefPubMedGoogle Scholar
  96. Van Dijk AA (1993) Development of recombinant vaccines against blue tongue. Biotechnol Adv 11(1):1–12CrossRefPubMedGoogle Scholar
  97. van Gennip RGP, van de Water SGP, Potgieter CA et al (2012) Rescue of recent virulent and avirulent field strains of bluetongue virus by reverse genetics. PLoS One 7(2):1–10Google Scholar
  98. Veronesi E, Darpel KE, Hamblin C, Carpenter S et al (2010) Viraemia and clinical disease in Dorset Poll sheep following vaccination with live attenuated bluetongue virus vaccines serotypes 16 and 4. Vaccine 28(5):1397–1403CrossRefPubMedGoogle Scholar
  99. Vidal M, Cairo J, Mateu MG, Villaverde A (1991) Molecular cloning and expression of the VP1 gene of footand-mouth disease virus C1 in E. coli: effect on bacterial cell viability. Appl Microbiol Biotechnol 35:788–792CrossRefPubMedGoogle Scholar
  100. Ward G, Rieder E, Mason PW (1997) Plasmid DNA encoding replicating foot-and-mouth disease virus genomes induces antiviral immune responses in swine. J Virol 71:7442–7447PubMedPubMedCentralGoogle Scholar
  101. Wigdorovitz A, Perez Filgueira DM, Robertson N, Carrillo C, Sadir AM, Morris TJ, Borca MV (1999) Protection of mice against challenge with foot and mouth disease virus (FMDV) by immunization with foliar extracts from plants infected with recombinant tobacco mosaic virus expressing the FMDV structural protein VP1. Virology 264:85–91CrossRefPubMedGoogle Scholar
  102. Wong HT, Cheng SC, Sin FW, Chan EW, Sheng ZT, Xie Y (2002) A DNA vaccine against foot-and-mouth disease elicits an immune response in swine which is enhanced by co-administration with interleukin-2. Vaccine 20:2641–2647CrossRefPubMedGoogle Scholar
  103. Yang NS, Wang JH, Lin KF, Wang CY et al (2005) Comparative studies of the capsid precursor polypeptide P1 and the capsid protein VP1 cDNA vectors for DNA vaccination against foot-and-mouth disease virus. J Gene Med 7:708–717CrossRefPubMedGoogle Scholar
  104. Zientara S, MacLachlan NJ, Calistri P et al (2010) Bluetongue vaccination in Europe. Exp Rev Vacc 9:989–991CrossRefGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • P. Minakshi
    • 1
  • Anuj Tiwari
    • 2
  • Beenu Jain
    • 3
  • Gaya Prasad
    • 4
  1. 1.Department of Animal BiotechnologyLUVASHisarIndia
  2. 2.Department of Veterinary MicrobiologyGBPUATPantnagarIndia
  3. 3.Department of Veterinary MicrobiologyLUVASHisarIndia
  4. 4.SVPUATMeerutIndia

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