Advertisement

Photoacoustic/Ultrasonic Dual-Modality Endoscopy in Vivo

  • Riqiang Lin
  • Yan Li
  • Jianhua Chen
  • Liang SongEmail author
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 64)

Abstract

Early diagnosis and treatment of cancer are of vital importance. Novel imaging methods are in great need to achieve this. Photoacoustic endoscopy (PAE) is an emerging endoscopic technology capable of providing both functional and molecular information of intact biological tissue of internal organs in vivo. With endogenous or exogenous contrast agent, cancer formation and the corresponding vascular morphology and function changes can be detected and imaged by PAE. In addition, Utilizing multi-wavelength laser excitation, a number of important physiological parameters, such as the total hemoglobin concentration, oxygen saturation of hemoglobin, and micro-hemodynamic flux, can be obtained by PAE. Such information directly correlates with vascular angiogenesis and abnormal metabolisms and thus reflects the formation and progression of many neoplasms.

Notes

Acknowledgements

This work was supported in part by the National Natural Science Foundation of China under Grant Nos. 81427804, 61205203, 61405234, and 61475182; the National Key Basic Research (973) Program of China under Grant Nos. 2014CB744503 and 2015CB755500; the Shenzhen Science and Technology Innovation under Grant Nos. ZDSY-2013-0401165820-357, KQCX-2012-0816155844-962, CXZZ-2012-0617113635-699, and JCYJ-2012-0615125857-842; Guangdong Innovation Research Team Fund for Low-cost Healthcare Technologies (GIRIF-LCHT).

References

  1. 1.
    World Cancer Report 2014. Vol. Chapter 1.1 (World Health Organization, 2014).Google Scholar
  2. 2.
    Yao, J. J., Maslov, K. I., Zhang, Y., Xia, Y. N. & Wang, L. V. Label-free oxygen-metabolic photoacoustic microscopy in vivo. J Biomed Opt 16, doi: Artn 076003,  https://doi.org/10.1117/1.3594786 (2011).
  3. 3.
    Yang, J. M. et al. Optical-resolution photoacoustic endomicroscopy in vivo. Biomed Opt Express 6, 918–932,  https://doi.org/10.1364/oe.23.00918 (2015).
  4. 4.
    Yang, J. M. et al. A 2.5-mm diameter probe for photoacoustic and ultrasonic endoscopy. Opt Express 20, 23944–23953,  https://doi.org/10.1364/oe.20.023944 (2012); Yang, J. M. et al. J Biomed Opt 19 (2014).CrossRefGoogle Scholar
  5. 5.
    Bai, X. S. et al. Intravascular Optical-Resolution Photoacoustic Tomography with a 1.1 mm Diameter Catheter. Plos One 9, ARTNe9246310.1371/journal.pone.0092463 (2014).CrossRefGoogle Scholar
  6. 6.
    Li, Y. et al. High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9 mm diameter catheter. J Biomed Opt 20,  https://doi.org/10.1117/1.jbo.20.6.065006 (2015).CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Research Laboratory for Biomedical Optics and Molecular Imaging, Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced Technology, Chinese Academy of SciencesShenzhenChina

Personalised recommendations