Photoacoustic/Ultrasonic Dual-Modality Endoscopy in Vivo
Early diagnosis and treatment of cancer are of vital importance. Novel imaging methods are in great need to achieve this. Photoacoustic endoscopy (PAE) is an emerging endoscopic technology capable of providing both functional and molecular information of intact biological tissue of internal organs in vivo. With endogenous or exogenous contrast agent, cancer formation and the corresponding vascular morphology and function changes can be detected and imaged by PAE. In addition, Utilizing multi-wavelength laser excitation, a number of important physiological parameters, such as the total hemoglobin concentration, oxygen saturation of hemoglobin, and micro-hemodynamic flux, can be obtained by PAE. Such information directly correlates with vascular angiogenesis and abnormal metabolisms and thus reflects the formation and progression of many neoplasms.
This work was supported in part by the National Natural Science Foundation of China under Grant Nos. 81427804, 61205203, 61405234, and 61475182; the National Key Basic Research (973) Program of China under Grant Nos. 2014CB744503 and 2015CB755500; the Shenzhen Science and Technology Innovation under Grant Nos. ZDSY-2013-0401165820-357, KQCX-2012-0816155844-962, CXZZ-2012-0617113635-699, and JCYJ-2012-0615125857-842; Guangdong Innovation Research Team Fund for Low-cost Healthcare Technologies (GIRIF-LCHT).
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