Pathophysiology of Large-Artery Atherosclerosis
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Large-artery atherosclerosis (LAA) is one of the major three causes of ischemic stroke, together with cardioembolism and small-vessel occlusion, accounting for approximately 20–30% of all cases, albeit by race and ethnicity. Pathophysiology of coronary atherosclerosis responsible for acute coronary syndrome is well established, and recent development of knowledge about atherosclerosis is mostly from studies on coronary diseases. Researches on cerebral atherosclerosis causing stroke has not been enough to fully elaborate its pathophysiology, but there are a lot of similarities and differences as compared to the pathophysiology of coronary atherosclerosis. In this chapter, I will describe mechanisms of LAA-related stroke in detail.
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