Mechanism of Recovery After Stroke

  • Seong-Ho KohEmail author
Part of the Stroke Revisited book series (STROREV)


Stroke is one of the biggest health problems in the world, especially considering the aging global population. Stroke causes diverse neurological sequelae, for which there is still no cure. In the clinic, it is not rare to see patients showing improvement in their neurological sequelae several weeks or months after stroke compared with their status in the early post-stroke stages. These phenomena are thought to be associated with the natural recovery process after stroke. The exact mechanisms underlying this recovery process are not yet known, but several plausible mechanisms have been suggested. The first is synaptic plasticity, which occurs through the processes of axonal sprouting and synaptogenesis. These processes occur in the peri-infarct area of the brain, but can sometimes be seen in the contralateral hemisphere. The second mechanism is neurogenesis, which arises from endogenous neural stem cells in the subventricular zone and the dentate gyrus in the hippocampus. In this chapter, the suggested plausible mechanisms underlying the natural recovery process that occurs after stroke will be discussed.


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Copyright information

© Springer Science+Business Media Singapore 2020

Authors and Affiliations

  1. 1.Department of NeurologyHanyang University Guri HospitalGuri-SiRepublic of Korea

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