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Host Genetic Characters of Acute Exacerbation of Chronic Hepatitis B (AECHB)

  • Yu-Ming Wang
  • Jun-Qi Niu
  • Guo-Hong Deng
  • Ying-Ren Zhao
Chapter

Abstract

This chapter describes the principles of genetic research, achievements in gene polymorphism and GWAS, epigenetics in AECHB and HBV ACLF.
  1. 1.

    The exacerbation of hepatitis B relates to the interactions between virus and host, including their molecular genetic characteristics. This is a core issue in basic research on severe hepatitis B.

     
  2. 2.

    The “quality” of an individual’s reaction to the virus and the environment is determined by host genetic variations on both protein and immune levels, with the “quantity” of the reaction determined by gene transcription and expression. Both fundamentally affect the occurrence and development of severe hepatitis B.

     
  3. 3.

    Genetic research strategies in severe hepatitis B include studies of candidate genes, genome-wide association and epigenetics.

     
  4. 4.

    The CXCL10 gene is an important candidate gene associated with severe hepatitis B. The G-201A sites of the CXCL10 promoter region are key regulators of the progression of severe hepatitis B.

     
  5. 5.

    Genome-wide association studies (GWAS) have become central of genetic studies on the complex diseases. The studies have surpassed the limitations of small-scale and local-site studies and have played an important role in revealing susceptible loci and biological pathways in severe hepatitis B. rs3129859 at human leucocyte antigen (HLA) class II region (chromosome 6p21.32) has been identified association with HBV-related ACLF.

     
  6. 6.

    Epigenetics, an emerging branch of genetics, does not involve changes in DNA sequence, or the heritable or reversible regulation of gene expression. Rather, epigenetics research mainly involves the regulation of DNA methylation, chromatin histone modification, chromatin remodeling and non-coding RNA. Although epigenetic modification studies in severe hepatitis B are at their initial stage, they are expected to become more important in the future.

     

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Copyright information

© Springer Nature B.V. and Huazhong University of Science and Technology Press 2019

Authors and Affiliations

  • Yu-Ming Wang
    • 1
  • Jun-Qi Niu
    • 2
  • Guo-Hong Deng
    • 1
  • Ying-Ren Zhao
    • 3
  1. 1.Southwest Hospital, Army Medical UniversityChongqingChina
  2. 2.The First Hospital of Jilin UniversityChangchunChina
  3. 3.The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina

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